Abstract: A method for preparing a finerenone intermediate compound of formula I from a diastereomeric tartrate by means of racemic resolution is provided. A compound of formula I having an ee value higher than 99.5% can be obtained. The preparation method provided has mild reaction conditions, simple post-treatment, and no special reagents required, and is suitable for industrial production.

Abstract: The present application discloses a method of treating brain cancer, comprising administering a therapeutically effective amount of an acid sensing ion channel 1a (ASIC1a) inhibitor to an tumorigenic subject in order to reduce injury resulting from brain cancer. Also disclosed are compositions for treatment of brain cancer, comprising: an acid sensing ion channel 1a (ASIC1a) inhibitor disposed in a vehicle at a concentration that provides a therapeutically effective amount of the ASIC1a inhibitor for treatment of brain cancer when administered to an tumorigenic subject. A method of manufacturing a medicament for treatment of brain cancer is also disclosed.

Abstract: A blood sample platelet uniform-mixing device for a blood analyzer includes a vortex oscillation device, the vortex oscillation device includes a fixing assembly, a rotating assembly and a vibrating assembly. The fixing assembly is used for fixing sample test tubes. The rotating assembly includes a rotating motor and a rotating disc. A rotating shaft of the rotating motor is connected with the rotating disc, the rotating disc is matched with the fixing assembly. A central axis of each of the sample test tubes fixed on the fixing assembly deviates from the rotating shaft of the rotating motor. The rotating assembly is used for rotating the fixing assembly and making a blood sample in each of the sample test tubes be in a vortex shape. The vibrating assembly is arranged on the fixing assembly.

Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.

Abstract: A system, including methods and compositions, for treatment of ischemia.

Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.

Abstract: A system, including methods and compositions, for treatment of ischemia.

Abstract: A system, including methods and compositions, for treatment of ischemia.

Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.

Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.

Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.

Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.

Abstract: A system, including methods and compositions, for treatment of ischemia.

Abstract: A system, including methods and compositions, for treatment of ischemia.

Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.

Abstract: A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC1a inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC1a inhibitors for use in the disclosed methods include amiloride and amiloride analogs.

Abstract: Palbociclib compositions with improved solubility and bioavailability, methods of their preparation, and methods of treating cancers using the compositions are disclosed.

Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.

Abstract: This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury in a subject. The formulation of such composition is also disclosed. The application further directs to methods for treating nerve injury or nervous system injury by administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising amiloride, an amiloride analog or a pharmaceutically acceptable salt thereof.

Abstract: A system, including methods and compositions, for treatment of ischemia.