Abstract: Disclosed are TCR-enriched clonotypes, and an acquisition method and use thereof. Amino acid sequences of the TCR-enriched clonotypes are: CAANRGSGYSTLTF (SEQ ID NO: 1)_CSARGERGEKLFF (SEQ ID NO: 2), CASSSGGSYIPTF (SEQ ID NO: 3)_CASSLAGGHETQYF (SEQ ID NO: 4), CAVNSYNTDKLIF (SEQ ID NO: 5)_CATSREEDNTYEQYF (SEQ ID NO: 6), CAVGGNEKLTF (SEQ ID NO: 7)_CASSQGTGRSSPLHF (SEQ ID NO: 8), or CAASAVGGAQKLVF (SEQ ID NO: 9)_CATSRGTLYGYTF (SEQ ID NO: 10), respectively. The TCR-enriched clonotypes can be used for vaccine development.

Abstract: The present disclosure discloses a sintered neodymium-iron-boron magnet and a preparation method thereof. The sintered neodymium-iron-boron magnet includes the following raw materials in mass percentage: 1%-40% of an iron powder or a steel powder with a magnetic induction intensity of more than 1.2 T, not more than 10% of a praseodymium-neodymium metal hydride powder, and a remainder of a neodymium-iron-boron fine powder, wherein the mass percentages of the above raw materials add up to 100%. The preparation method includes: weighing the raw materials in mass percentage; mixing the weighed raw materials uniformly, and then subjecting to magnetic-field press molding, isostatic pressing, sintering and tempering to obtain the sintered neodymium-iron-boron magnet.

Abstract: The present disclosure discloses a sintered neodymium-iron-boron magnet and a preparation method thereof. The sintered neodymium-iron-boron magnet includes the following raw materials in mass percentage: 1%-40% of an iron powder or a steel powder with a magnetic induction intensity of more than 1.2 T, not more than 10% of a praseodymium-neodymium metal hydride powder, and a remainder of a neodymium-iron-boron fine powder, wherein the mass percentages of the above raw materials add up to 100%. The preparation method includes: weighing the raw materials in mass percentage; mixing the weighed raw materials uniformly, and then subjecting to magnetic-field press molding, isostatic pressing, sintering and tempering to obtain the sintered neodymium-iron-boron magnet.

Abstract: The present disclosure provides the use of mesenchymal stem cells (MSC) in the treatment of viral infection and/or complications caused by the viral infection. MSC can highly express multiple antioxidative stress genes and secrete multiple antioxidative stress factors under the stimulation of oxidative stress, inhibit inflammatory reaction and excessive activation of immune cells, thus improving inflammatory indexes and myocardial injury indexes of human bodies. MSC can regulate the expression profile of monocyte genes and monocyte toxicity genes in patients with viral infection, inhibit the excessive immune response, protect alveolar function, and reduce the damage of lung and whole body organs in patients with viral infection.

Abstract: Disclosed are TCR-enriched clonotypes, and an acquisition method and use thereof. Amino acid sequences of the TCR-enriched clonotypes are: CAANRGSGYSTLTF_CSARGERGEKLFF, CASSSGGSYIPTF_CASSLAGGHETQYF, CAVNSYNTDKLIF_CATSREEDNTYEQYF, CAVGGNEKLTF_CASSQGTGRSSPLHF, or CAASAVGGAQKLVF_CATSRGTLYGYTF, respectively. The TCR-enriched clonotypes can be used for vaccine development.

Abstract: A POSS-based non-isocyanate polyurethane modified poly(propylene carbonate) and a method of making are described. The POSS-based non-isocyanate polyurethane modified poly(propylene carbonate) includes a poly(propylene carbonate) and 1 to 20 wt % of a POSS-based non-isocyanate polyurethane. The method includes subjecting a POSS-based epoxy compound to a cycloaddition reaction with CO2 to obtain a POSS-based cyclic carbonate under an action of a catalyst, and subjecting the POSS-based cyclic carbonate to a ring-opening reaction with a monoamino compound to obtain the POSS-based non-isocyanate polyurethane. Polyurethane bonds and hydroxyl in the POSS-based non-isocyanate polyurethane serve as proton donors and forms a high-density of hydrogen bonds with carbonate units of the poly(propylene carbonate), enhancing the compatibility of the POSS-based non-isocyanate polyurethane with the poly(propylene carbonate).

Abstract: The present invention discloses POSS-based non-isocyanate polyurethane modified poly(propylene carbonate), comprising poly(propylene carbonate) and 1 to 20 wt % of POSS-based non-isocyanate polyurethane. The POSS-based non-isocyanate polyurethane has a structure shown by the formula (I) or the formula (II). Under the action of a catalyst, POSS-based epoxy compound is subjected to cycloaddition reaction with CO2 to obtain POSS-based cyclic carbonate, and then the POSS-based cyclic carbonate is subjected to ring-opening reaction with monoamino compound to prepare the POSS-based non-isocyanate polyurethane. POSS has both the flexibility of organic silicon materials and the strength of inorganic silicon materials to enhance the toughening and strengthening of of poly(propylene carbonate).