Abstract: The disclosure discloses a preparation method and product of carbon fiber reinforced polymer composites with a designable characteristic structure. The method includes: (a) choosing carbon fabrics as raw material, where a predetermined number of the fabrics are selected to deposit the reinforcement phase; (b) coating all carbon fabrics with resin matrix, placing the fabrics layer by layer, where the carbon fabrics with the reinforcement phases are placed in a predetermined layer, meanwhile a micro power supply is placed in a setting layer during the stacking process, then a prefabricated product is obtained; (c) placing the prefabricated product in a vacuum bag then evacuating and sealing, hot pressing the sealed prefabricated product, finally the carbon fiber reinforced polymer composite product in the vacuum bag after hot pressing is successfully manufactured.

Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, including but not limited to leukemia, myelodysplastic syndrome (MDS), and myeloproliferative neoplasms (MPN); and diabetes.

Abstract: A fused bicyclic derivative shown in general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and a use thereof as a therapeutic agent, particularly the use thereof as an AKT1/2/3 (AKT pan) inhibitor and the use in the preparation of a medication for treating and/or preventing tumors. Each group in general formula (I) is as defined in the description.

Abstract: The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.

Abstract: The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.

Abstract: A condensed ring group azacyclobutyl triazole derivative, a preparation method therefor and use thereof in medicine are provided. In particular, a condensed ring group azacyclobutyl triazole derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, use thereof as a therapeutic agent, in particular as an oxytocin antagonist, and for treating or preventing a disease or a condition that is known or can exhibit a beneficial effect of inhibiting oxytocin are provided. The definition for each substituent in general formula (I) is the same as that in the description.

Abstract: A hydraulic support unit and a hydraulic support for anti-rock burst roadway. The hydraulic support unit includes a base, a top beam, and a hydraulic support column, the top beam is positioned above the base in a spaced manner; the hydraulic support column are disposed between the base and the top beam; a side guard plate and a first base hydraulic cylinder are disposed on the left side and right side of the base, the side guard plates are rotably connected to the base, the two ends of the first base hydraulic cylinder are hinged to the base and the side guard plate respectively, the first base hydraulic cylinder can drive the side guard plate to transit between a horizontal state and a vertical state, and the bottom surfaces of the side guard plates are flush with the bottom surface of the base in the horizontal state.

Abstract: A condensed ring group azacyclobutyl triazole derivative, a preparation method therefor and use thereof in medicine are provided. In particular, a condensed ring group azacyclobutyl triazole derivative as represented by general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, use thereof as a therapeutic agent, in particular as an oxytocin antagonist, and for treating or preventing a disease or a condition that is known or can exhibit a beneficial effect of inhibiting oxytocin are provided. The definition for each substituent in general formula (I) is the same as that in the description.

Abstract: This disclosure relates to a three-phase electric energy measurement apparatus, comprising: a voltage detection unit for detecting voltage of each phase in power transmitting lines where the voltage detection unit is; a current detection unit for detecting current of each phase in the power transmitting lines where the current detection unit is; an electric energy calculation unit, connected to said voltage detection unit and said current detection unit, for receiving signals outputted from said voltage detection unit and said current detection unit, and performing signal processing and calculation, and then outputting a calculation result; wherein both said voltage detection unit and said electric energy calculation unit are connected in a star connection mode, forming a common virtual ground. Through the above-mentioned grounding manner different from that in the prior art, a three-phase four-wire electric energy meter is formed using a three-phase three-wire connection method.

Abstract: This disclosure relates to a three-phase electric energy measurement apparatus, comprising: a voltage detection unit for detecting voltage of each phase in power transmitting lines where the voltage detection unit is; a current detection unit for detecting current of each phase in the power transmitting lines where the current detection unit is; an electric energy calculation unit, connected to said voltage detection unit and said current detection unit, for receiving signals outputted from said voltage detection unit and said current detection unit, and performing signal processing and calculation, and then outputting a calculation result; wherein both said voltage detection unit and said electric energy calculation unit are connected in a star connection mode, forming a common virtual ground. Through the above-mentioned grounding manner different from that in the prior art, a three-phase four-wire electric energy meter is formed using a three-phase three-wire connection method.