Abstract: The invention relates to human nucleotide sequences which occur as a result of the t(1;22)(p13;q13) chromosomal translocation event which is known to occur almost invariable in young children with acute megakaryoblastic leukemia. The translocation results in the formation of fusion genes which encode fusion proteins. The invention provides the nucleotide sequences of transcripts of the fusion genes and the amino acid sequences of the fusion proteins encoded thereby. Also provided are methods for detecting the t(1, 22) translocation, for identifying agents capable of binding to the fusion protein and for identifying agents useful for treating patients with acute megakaryoblastic leukemia.

Abstract: The invention relates to human nucleotide sequences which occur as a result of the t(1;22)(p13;q13) chromosomal translocation event which is known to occur almost invariable in young children with acute megakaryoblastic leukemia. The translocation results in the formation of fusion genes which encode fusion proteins. The invention provides the nucleotide sequences of transcripts of the fusion genes and the amino acid sequences of the fusion proteins encoded thereby. Also provided are methods for detecting the t(1, 22) translocation, for identifying agents capable of binding to the fusion protein and for identifying agents useful for treating patients with acute megakaryoblastic leukemia.

Abstract: A heat exchanger consists of an outer casing, core tube device, flow guide plate and sealing means. The outer casing comprising the lower and upper outer casings has the front and rear enclosed plates fixed to both ends to form a closed casing. The core tube device provided at the middle portion of the outer casing includes a core tube body, end enclosed plates and heat exchanging copper tubes. The flow guide plate is located between the inner wall of the outer casing and the outer wall of the core tube body with the sealing means provided between the upper and lower outer casings and secured into an integral casing by bolts and nuts. The exhausted hot water enters the heat exchanger from the inlet on the outer casing and exits the outlet while the clean tap water enters the heat exchanger from the opposite inlet provided on the core tube device.

Abstract: An assembling heat exchanger of spiral sleeve consist of the outer casings, core tube device, flow guide plate and sealing means. The outer casing comprising the lower and upper outer casings has the front and rear enclosed plates fixed to its both ends to form a closed casing. The core tube device provided at the middle portion of the outer casing includes the core tube body, end enclosed plates and heat exchanging copper tubes. The flow guide plate is located between the inner wall of the outer casing and the outer wall of the core tube body with the sealing means provided between the upper and lower outer casings and secured into an integral casing by bolts and nuts. The exhausted hot water enters the heat exchanger from the inlet on the outer casing and exit the outlet while the clean tap water enters the heat exchanger from the opposite inlet provided on the core tube device.