Patents by Inventor Zhiguo Zhou

Zhiguo Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240024988
    Abstract: In the automatic welding method and device for prestressed tubular piles provided in the present application, which is applied in welding equipment, a detection is conducted around a connection position between prestressed tubular piles and a position of a target welding seam is obtained. Then the target welding seam is welded around the prestressed tubular piles according to the position of the target welding seam.
    Type: Application
    Filed: February 14, 2023
    Publication date: January 25, 2024
    Inventors: Xiaoli SUN, Zhiguo ZHOU, Jun YANG, Liangjun HU, Jixi SHAO, Decun BIAN, Yuzhu ZHANG, Hao LI, Lu LIU, Yongxiao DU, Xiaohua YUAN
  • Publication number: 20230176072
    Abstract: An immunoassay platform and methodology are described for discriminatively detecting target microorganism antibodies to a target antigen in a biological sample derived from a host animal, from among antibodies of cross-reactively-related microorganism(s) potentially present in the biological sample, by use of contemporaneous assays conducted with and without blocking antibodies exogenous to the host animal. Attenuation of detection reagent signal between the contemporaneous assays may be used to determine a target antigen previously infected or non-infected status of the host animal.
    Type: Application
    Filed: December 2, 2021
    Publication date: June 8, 2023
    Inventors: Yan ZHOU, Zhiguo ZHOU, Qian LI
  • Patent number: 11604182
    Abstract: Provided is an apparatus and method for detecting grout compactness in grouted splice sleeve, the apparatus comprises a probe assembly, which comprises at least one of capacitive probe and piezoelectric sensor and is arranged inside the grouted splice sleeve to detect parameters of the sleeve during grouting and curing and a detector, which comprises at least an analysis module that is connected with the probe assembly to obtain the detected parameters and carry out calculation and analysis for the parameters. The probe assembly is arranged inside the grouted splice sleeve and forms a loop with the detector during grouting, such that during the process of grouting, the detected parameters will be changed as the surrounding dielectric changes, therefore, the detector may determine in real time whether the grouted splice sleeve is fully grouted by calculating and analyzing the detected parameters, which achieves a faster and easier grout compactness detection.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: March 14, 2023
    Assignees: GUANGZHOU MUNICIPAL ENGINEERING TESTING CO., LTD., GUANGZHOU CONSTRUCTION ENGINEERING CO., LTD., GUANGZHOU MUNICIPAL CONSTRUCTION GROUP CO., LTD.
    Inventors: Mengxiong Tang, Zhiguo Zhou, Xiaoli Sun, Hongye Wang, Jun Yang, Hesong Hu, Wuyang Zhou, Decun Bian, Yayu Zhao, Jixi Shao, Ducheng Guo, Hongbin Zhao
  • Patent number: 11505908
    Abstract: Provided is a drilling apparatus, comprising a PHC pipe cased pile having a drilling section for containing fluid and a hammer element arranged inside the cavity of the PHC pipe cased pile which moves along the drilling direction till the bottom of the drilling section. As the hammer element moves along the drilling direction till the bottom of the drilling section, a localized hydraulic force will be induced in the fluid contained in the drilling section of the PHC pipe cased pile by a sharp rise in the fluid pressure in addition to the impact force directly acted on the rock and soil by the hammer element. Under action of the hydraulic force and the impact force, the surrounding soft rock stratum could be crushed and the rock stratum with higher strength is left intact, that is, the drilling apparatus proceeds until harder rock. At this point, concrete casting will bond with the harder rock, resulting in a better bearing capacity of the PHC pipe cased pile foundation.
    Type: Grant
    Filed: January 26, 2021
    Date of Patent: November 22, 2022
    Assignees: GUANGZHOU MUNICIPAL ENGINEERING TESTING CO., LTD., GUANGZHOU INSTITUTE OF BUILDING SCIENCE CO., LTD., GUANGZHOU CONSTRUCTION ENGINEERING CO., LTD., GUANGZHOU MUNICIPAL CONSTRUCTION GROUP CO., LTD.
    Inventors: Mengxiong Tang, Zhiguo Zhou, Xiaoli Sun, Jun Yang, Hesong Hu
  • Publication number: 20220180408
    Abstract: A method, system, and computer program product are described for quantitation of human food tastes. Such quantitation involves taste calibration of human food tasters, to constitute an initiation cohort of trained tasters who then taste and quantitatively score food items, from which a computing device determination of a normative distributized score for the food items is transmitted to user devices for quantitative guidance in selection of food and food providers, with food consumers receiving such quantitative guidance subsequently electively providing consumer scoring to enhance consistency and reliability of the food taste quantitation.
    Type: Application
    Filed: December 6, 2020
    Publication date: June 9, 2022
    Inventors: Zhiguo Zhou, Yu Ye
  • Publication number: 20220081863
    Abstract: Provided is a drilling apparatus, comprising a PHC pipe cased pile having a drilling section for containing fluid and a hammer element arranged inside the cavity of the PHC pipe cased pile which moves along the drilling direction till the bottom of the drilling section. As the hammer element moves along the drilling direction till the bottom of the drilling section, a localized hydraulic force will be induced in the fluid contained in the drilling section of the PHC pipe cased pile by a sharp rise in the fluid pressure in addition to the impact force directly acted on the rock and soil by the hammer element. Under action of the hydraulic force and the impact force, the surrounding soft rock stratum could be crushed and the rock stratum with higher strength is left intact, that is, the drilling apparatus proceeds until harder rock. At this point, concrete casting will bond with the harder rock, resulting in a better bearing capacity of the PHC pipe cased pile foundation.
    Type: Application
    Filed: January 26, 2021
    Publication date: March 17, 2022
    Inventors: Mengxiong TANG, Zhiguo ZHOU, Xiaoli SUN, Jun YANG, Hesong HU
  • Publication number: 20210349073
    Abstract: Provided is an apparatus and method for detecting grout compactness in grouted splice sleeve, the apparatus comprises a probe assembly, which comprises at least one of capacitive probe and piezoelectric sensor and is arranged inside the grouted splice sleeve to detect parameters of the sleeve during grouting and curing and a detector, which comprises at least an analysis module that is connected with the probe assembly to obtain the detected parameters and carry out calculation and analysis for the parameters. The probe assembly is arranged inside the grouted splice sleeve and forms a loop with the detector during grouting, such that during the process of grouting, the detected parameters will be changed as the surrounding dielectric changes, therefore, the detector may determine in real time whether the grouted splice sleeve is fully grouted by calculating and analyzing the detected parameters, which achieves a faster and easier grout compactness detection.
    Type: Application
    Filed: December 15, 2020
    Publication date: November 11, 2021
    Inventors: Mengxiong TANG, Zhiguo ZHOU, Xiaoli SUN, Hongye WANG, Jun YANG, Hesong HU, Wuyang ZHOU, Decun BIAN, Yayu ZHAO, Jixi SHAO, Ducheng GUO, Hongbin ZHAO
  • Patent number: 9233177
    Abstract: Endohedral metallofullerene compounds, which in water has a relaxivity of about 30 mM?1 S?1 to about 300 mM?1 S?1 and forms a dispersion in water with entities having an average hydrodynamic radius of less than about 20 nm.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: January 12, 2016
    Assignee: Luna Innovations Incorporated
    Inventors: Darren K. Macfarland, Robert P. Lenk, Rajesh Shukla, Kenneth L. Walker, Stephen R. Wilson, Zhiguo Zhou
  • Publication number: 20140161733
    Abstract: A composition comprising: a liposome having a bilayer structure, a gadofullerene having a high relaxivity, and an amphiphilic receptor ligand. In the composition, the gadofullerene is embedded in the bilayer structure of the liposome. In addition, a method for detecting atherosclerotic plaque in an animal using the composition is described.
    Type: Application
    Filed: March 29, 2012
    Publication date: June 12, 2014
    Applicant: LUNA INNOVATIONS INCORPORATED
    Inventors: Zhiguo Zhou, Robert P. Lenk, Christopher L. Kepley
  • Patent number: 8680125
    Abstract: Described herein are methods for treating inflammatory disorders. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: March 25, 2014
    Assignee: Luna Innovations Incorporated
    Inventors: Christopher L. Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou, Darren K. MacFarland
  • Patent number: 8563585
    Abstract: Described herein are methods for treating inflammatory disorders. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene.
    Type: Grant
    Filed: March 3, 2009
    Date of Patent: October 22, 2013
    Assignee: Luna Innovations, Incorporated
    Inventors: Christopher L. Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou, Darren K. MacFarland
  • Patent number: 8394811
    Abstract: A method of identification of compounds that modulate thyroid hormone activity, and the use of such compounds and compositions thereof for such purposes are disclosed. The compounds may be selected from the group consisting of: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant thyroid hormone activity, such as hyperthyroidism and thyrotoxicosis.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: March 12, 2013
    Assignees: Molsoft LLC, New York University School of Medicine
    Inventors: Herbert H. Samuels, Ruben Abagyan, Matthieu Schapira, Maxim Totrov, Bruce M. Raaka, Stephen R. Wilson, Li Fan, Zhiguo Zhou
  • Patent number: 8241648
    Abstract: Described herein are synthetically modified fullerene molecules, wherein the fullerene is preferably ellipsoid in shape with an equatorial band and two opposing poles, comprising an adduct at one or both poles, at least one adduct being a hydrophobic chemical moiety capable of anchoring the fullerene on or in a lipid membrane.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: August 14, 2012
    Assignee: Luna Innovations Incorporated
    Inventors: Zhiguo Zhou, Robert P. Lenk, Darren Macfarland, Kenneth L. Walker, Jing Zhang, Stephen R. Wilson
  • Publication number: 20110251158
    Abstract: Described herein are methods for treating inflammatory disorders or for inhibiting the build-up of arterial plaque. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene.
    Type: Application
    Filed: September 16, 2010
    Publication date: October 13, 2011
    Applicant: Luna Innovations Incorporated
    Inventors: Christopher L. KEPLEY, Robert P. LENK, Darren K. MACFARLAND, Zhiguo ZHOU
  • Publication number: 20110190251
    Abstract: Disclosed herein are methods of inhibiting the build-up of arterial plaque in a subject in need thereof. These methods comprise administering to the subject in need thereof a therapeutically effective amount of fullerenes.
    Type: Application
    Filed: March 3, 2009
    Publication date: August 4, 2011
    Inventors: Christopher L. Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou
  • Publication number: 20110124848
    Abstract: Endohedral metallofullerene compounds, which in water has a relaxivity of about 30 mM?1 S?1 to about 300 mM?1 S?1 and forms a dispersion in water with entities having an average hydrodynamic radius of less than about 20 nm.
    Type: Application
    Filed: October 22, 2008
    Publication date: May 26, 2011
    Applicant: LUNA INNOVATIONS INCORPORATED
    Inventors: Darren K. Macfarland, Robert P. Lenk, Rajesh Shukla, Kenneth L. Walker, Stephen R. Wilson, Zhiguo Zhou
  • Publication number: 20110028522
    Abstract: Described herein are methods for treating inflammatory disorders. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene.
    Type: Application
    Filed: March 3, 2009
    Publication date: February 3, 2011
    Applicant: LUNA INNOVATIONS INCORPORATED
    Inventors: Christopher L. Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou, Darren K. MacFarland
  • Publication number: 20110021630
    Abstract: Disclosed herein are methods for treating wounds. In one embodiment, the method comprises: administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene of the formula Zm—F—Yn wherein F is a fullerene of formula Cp or X@Cp, the fullerene having two opposing poles and an equatorial region; Cp represents a fullerene cage having p carbon atoms, and X@CP represents such a fullerene cage having a chemical group X within the cage; Z and Y are positioned near respective opposite poles of Cp; m=1-5 and Z is a hydrophilic, lipophilic, or amphiphilic chemical moiety; n=1-5 and Y is a lipophilic chemical moiety; p=60-200 and p is an even number; and X, if present, represents one or more metal atoms within the fullerene (F), optionally in the form of a trinitride of formula Gi=1?3Hk=3?iN in which G and H are metal atoms.
    Type: Application
    Filed: March 3, 2009
    Publication date: January 27, 2011
    Inventors: Christopher L. Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou
  • Publication number: 20110009486
    Abstract: Disclosed herein are methods of treating pruritus in a subject in need thereof. A method of treating pruritus comprises administering a therapeutically effective amount of fullerenes to a subject in need thereof.
    Type: Application
    Filed: March 3, 2009
    Publication date: January 13, 2011
    Applicant: Luna Innovations Incorporated
    Inventors: Christopher Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou
  • Publication number: 20110003773
    Abstract: Described herein are methods for treating lack of hair growth or a reduction or loss of existing hair by stimulating and/or restoring hair growth, or preventing hair loss. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a fullerene.
    Type: Application
    Filed: March 3, 2009
    Publication date: January 6, 2011
    Applicant: Luna Innovations Incorporated
    Inventors: Christopher L. Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou