Patents by Inventor Zhihao Hu

Zhihao Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160032328
    Abstract: The invention relates to the use of EntD polypeptides, polynucleotides encoding the same, and homologues thereof to enhance the production of fatty aldehydes and fatty alcohols in a host cell.
    Type: Application
    Filed: February 13, 2014
    Publication date: February 4, 2016
    Applicant: REG Life Sciences, LLC
    Inventors: Zhihao HU, Derek L. GREENFIELD, Vikranth ARLAGADDA
  • Patent number: 9175234
    Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: November 3, 2015
    Assignee: REG Life Sciences, LLC
    Inventors: Louis Hom, Na Trinh, Murtaza Alibhai, Zhihao Hu, Eli Groban, Vikranth Arlagadda, Elizabeth Clarke
  • Publication number: 20150275188
    Abstract: Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.
    Type: Application
    Filed: March 18, 2015
    Publication date: October 1, 2015
    Applicant: REG LIFE SCIENCES, LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Publication number: 20150259714
    Abstract: Disclosed herein are various embodiments regarding the production of mixed fatty esters. Disclosed herein are various embodiments regarding the use of mixed alcohol compositions for the production of fatty esters.
    Type: Application
    Filed: January 8, 2015
    Publication date: September 17, 2015
    Applicant: REG LIFE SCIENCES, LLC
    Inventors: ZHIHAO HU, GRACE J. LEE, DOUGLAS C. CAMERON
  • Patent number: 9068201
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Grant
    Filed: October 8, 2012
    Date of Patent: June 30, 2015
    Assignee: REG Life Sciences, LLC.
    Inventors: Zhihao Hu, Vikranth Arlagadda
  • Publication number: 20150167033
    Abstract: Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.
    Type: Application
    Filed: March 8, 2012
    Publication date: June 18, 2015
    Applicant: LS9, INC.
    Inventors: Grace J. Lee, John R. Haliburton, Zhihao Hu, Andreas W. Schirmer
  • Publication number: 20150125933
    Abstract: The invention relates to compositions, including polynucleotide sequences, amino acid sequences, recombinant microorganisms, and recombinant microorganism cultures that produce compositions of fatty acids and derivatives having target aliphatic chain lengths and/or preferred percent saturation. Further, the invention relates to methods of making and using the compositions. The compositions and methods provide for high titers, high yields, and high productivities of fatty acids and derivatives thereof.
    Type: Application
    Filed: August 17, 2012
    Publication date: May 7, 2015
    Applicant: LS9, INC.
    Inventors: Eli S. Groban, Vikranth Arlagadda, Scott A. Frykman, Derek L. Greenfield, Zhihao Hu
  • Patent number: 9017984
    Abstract: Genetically engineered microorganisms that produce fatty alcohols from a sugar source by way of the fatty acid biosynthetic pathway, as well as methods of their use are provided.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: April 28, 2015
    Assignee: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Patent number: 8999686
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: April 7, 2015
    Assignee: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Vikranth Arlagadda
  • Publication number: 20150064757
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Application
    Filed: April 2, 2013
    Publication date: March 5, 2015
    Applicant: REG Life Sciences, LLC
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu
  • Publication number: 20150064782
    Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.
    Type: Application
    Filed: April 2, 2013
    Publication date: March 5, 2015
    Applicant: REG LIFE SCIENCES, LLC
    Inventors: Derek L. Greenfield, Andreas W. Schirmer, Elizabeth J. Clarke, Eli S. Groban, Bernardo M. Da Costa, Zhihao Hu
  • Publication number: 20140179940
    Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
    Type: Application
    Filed: April 2, 2012
    Publication date: June 26, 2014
    Inventors: Derek L. Greenfield, Louis G. Hom, Fernando A. Sanchez-Riera, Zhihao Hu, Vikranth Arlagadda, Eli S. Groban, Scott A. Frykman
  • Publication number: 20140005855
    Abstract: A device for calculating mileage is disclosed. The device includes an estimation calculator, a mileage calculator, and a filter. The estimation calculator is configured for determining a first battery power consumed over a first predetermined distance, wherein the first battery power is determined based on a velocity and an initial remaining power. The mileage calculator is coupled to the estimation calculator, and is configured for determining an estimated remaining mileage based on the first battery power, the first predetermined distance, and a power balance. A filter is coupled to the estimation calculator and the mileage calculator, and is configured for smoothing the estimated remaining mileage and outputting a smoothed estimated remaining mileage.
    Type: Application
    Filed: July 19, 2012
    Publication date: January 2, 2014
    Applicant: O2MICRO INC.
    Inventors: Zhihao Hu, Falong Li
  • Publication number: 20130335036
    Abstract: A balance charging detector is configured to detect a balance charging condition for a battery. The balance charging detector includes a controller and a comparing module. The controller is configured to monitor a status of the battery, access battery parameters for the battery that correspond to the status, and generate a group of balance charging parameters based on the battery parameters. The comparing module is configured to set a balance charging flag based on a comparison of the group of balance charging parameters and a set of thresholds. A balance charging signal can be generated if the balance charging flag is set to indicate presence of a condition to perform a balance charging of the battery.
    Type: Application
    Filed: June 29, 2012
    Publication date: December 19, 2013
    Inventors: Tao ZHANG, Jiangiang RUI, Falong LI, Zhihao HU
  • Publication number: 20130245339
    Abstract: Compositions and methods for production of fatty alcohols using recombinant microorganisms are provided as well as fatty alcohol compositions produced by such methods.
    Type: Application
    Filed: April 25, 2013
    Publication date: September 19, 2013
    Inventors: Jay D. KEASLING, Zhihao HU, Chris SOMERVILLE, George CHURCH, David BERRY, Lisa FRIEDMAN, Andreas SCHIRMER, Shane BRUBAKER, Stephen B. DEL CARDAYRE
  • Patent number: 8530221
    Abstract: Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: September 10, 2013
    Assignee: LS9, Inc.
    Inventors: Zhihao Hu, Grace J. Lee, Andreas W. Schirmer, Kseniya Zakharyevich, Derek L. Greenfield, Tarah S. Baron, Kevin Holden
  • Publication number: 20130115665
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Application
    Filed: October 8, 2012
    Publication date: May 9, 2013
    Applicant: LS9, Inc.
    Inventors: Zhihao HU, Vikranth Arlagadda
  • Patent number: 8372610
    Abstract: Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: February 12, 2013
    Assignee: LS9, Inc.
    Inventors: Grace J. Lee, John R. Haliburton, Zhihao Hu, Andreas W. Schirmer
  • Publication number: 20130035513
    Abstract: The invention relates to the use of EntD polypeptides, polynucleotides encoding the same, and homologues thereof to enhance the production of fatty aldehydes and fatty alcohols in a host cell.
    Type: Application
    Filed: January 26, 2012
    Publication date: February 7, 2013
    Applicant: LS9, INC.
    Inventors: Zhihao HU, Derek L. Greenfield, Vikranth Arlagadda
  • Publication number: 20120264983
    Abstract: Genetically engineered microorganisms that produce fatty alcohols from a sugar source by way of the fatty acid biosynthetic pathway, as well as methods of their use are provided.
    Type: Application
    Filed: June 21, 2012
    Publication date: October 18, 2012
    Applicant: LS9, INC.
    Inventors: Zhihao Hu, Fernando Valle