Abstract: Provided herein is a bispecific antibody and the use thereof. The bispecific antibody includes an antibody or antibody fragment; the antibody or the antibody fragment is a bispecific antibody or an antibody fragment comprising a first heavy chain, a first light chain, a second heavy chain, and a second light chain; the first Fab region comprises the first heavy chain and the first light chain; the second Fab region comprises the second heavy chain and the second light chain; and a variety of mutations are introduced in the first Fab region and the second Fab region.

Abstract: Methods and systems for providing landing area information on an active avionic display on a display device in a cockpit of an aircraft. The system includes an avionic display module configured to render an avionic display on a display device; and a landing area guidance module configured to: construct a graphical insert that is smaller than the avionic display, the graphical insert depicting the landing area environment as a two-dimensional area that includes a landing location rendered therein in a first visualization scheme; overlay the graphical insert on a small portion of the avionic display; indicate a target exit on the landing location; determine whether a runway overrun awareness alerting system (ROAAS) alert has been received; determine whether a surface indication alerts (SurfIA) alert has been received; responsive to the ROAAS alert and the SurfIA alert, alter the rendering within the graphical insert.

Abstract: Methods and systems of displaying weather data for a cockpit display system of an aircraft. The methods and systems include generating a display to include a first graphical map of real-time weather data from a weather radar. The display further includes a notification graphic associated with a portion of part of a displayed flight plan in which a significant weather condition exists. When the notification graphic is selected, the display includes the first graphical map of the real time weather data based on weather data from the weather radar and a second graphical map of significant weather conditions data derived from transmitted weather data.

Abstract: Systems and methods for suggesting, on an avionic display in an aircraft, a communication frequency that is relevant to a context of the aircraft. The method includes determining a location and orientation of the aircraft and referencing an intended flight path to determine, based thereon, the context of the aircraft. The method uses the context to reference an on-board source of a plurality of stored navigation communication frequencies. The method identifies one or more relevant navigation communication frequencies for the context and presents the relevant navigation communication frequencies in a predefined area on an avionic display.

Abstract: Methods and systems for providing landing area information on an active avionic display on a display device in a cockpit of an aircraft. The system includes an avionic display module configured to render an avionic display on a display device; and a landing area guidance module configured to: construct a graphical insert that is smaller than the avionic display, the graphical insert depicting the landing area environment as a two-dimensional area that includes a landing location rendered therein in a first visualization scheme; overlay the graphical insert on a small portion of the avionic display; indicate a target exit on the landing location; determine whether a runway overrun awareness alerting system (ROAAS) alert has been received; determine whether a surface indication alerts (SurfIA) alert has been received; responsive to the ROAAS alert and the SurfIA alert, alter the rendering within the graphical insert.

Abstract: Methods and systems of displaying weather data for a cockpit display system of an aircraft. The methods and systems include generating a display to include a first graphical map of real-time weather data from a weather radar. The display further includes a notification graphic associated with a portion of part of a displayed flight plan in which a significant weather condition exists. When the notification graphic is selected, the display includes the first graphical map of the real time weather data based on weather data from the weather radar and a second graphical map of significant weather conditions data derived from transmitted weather data.