Patents by Inventor Zhihe Yang

Zhihe Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Histone methyltransferase EZH2 inhibitor, preparation method and pharmaceutical use thereof
    Patent number: 11214561
    Abstract: The invention relates to a histone methyltransferase EZH2 inhibitor, a preparation method and pharmaceutical use thereof. In particular, the invention relates to a compound represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing the same, and a use thereof as a histone methyltransferase EZH2 inhibitor for treating diseases associated with the histone methyltransferase EZH2, especially cancer. The definition of each substituents in the general formula (I) is same as the definition in the specification.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: January 4, 2022
    Assignee: Ancureall Pharmaceutical (Shanghai) Co., Ltd.
    Inventors: Jutong Si, Guan Wang, Meifeng Jiang, Zhihe Yang, Chentao Zhou
  • PYRIMIDINE COMPOUND, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF
    Publication number: 20210101881
    Abstract: The present invention discloses a pyrimidine compound, a preparation method thereof and a medical use thereof. Specifically, the present invention discloses a pyrimidine compound represented by formula (I), pharmaceutically acceptable salts thereof, a preparation method thereof, and a use thereof as a cyclin-dependent kinase 9 (CDK9) inhibitor, particularly for the treatment of cancer. The definition of each group in formula (I) is the same as that in the specification.
    Type: Application
    Filed: January 29, 2019
    Publication date: April 8, 2021
    Inventors: Jutong Si, Meifeng Jiang, Zhihe Yang, Liyun Zhang
  • HISTONE METHYLTRANSFERASE EZH2 INHIBITOR, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
    Publication number: 20190345139
    Abstract: The invention relates to a histone methyltransferase EZH2 inhibitor, a preparation method and pharmaceutical use thereof. In particular, the invention relates to a compound represented by the general formula (I), a preparation method thereof, a pharmaceutical composition containing the same, and a use thereof as a histone methyltransferase EZH2 inhibitor for treating diseases associated with the histone methyltransferase EZH2, especially cancer. The definition of each substituents in the general formula (I) is same as the definition in the specification.
    Type: Application
    Filed: January 24, 2018
    Publication date: November 14, 2019
    Inventors: Jutong Si, Guan Wang, Meifeng Jiang, Zhihe YANG, Chentao Zhou
  • Acrylanilide derivative, preparation method, and applications thereof in pharmacy
    Patent number: 10342796
    Abstract: Disclosed in the present invention are an acrylanilide compound represented by general formula (I) and a pharmaceutically acceptable salt thereof. The acrylanilide compound and the pharmaceutically acceptable salt thereof are used for treating clinical diseases by mainly acting on EGFR family casein kinases.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: July 9, 2019
    Assignee: Ancureall Pharmaceutical (Shanghai) Co., Ltd.
    Inventors: Jutong Si, Guan Wang, Zhihe Yang, Meifeng Jiang, Benpo Xu, Chentao Zhou
  • ACRYLANILIDE DERIVATIVE, PREPARATION METHOD, AND APPLICATIONS THEREOF IN PHARMACY
    Publication number: 20190015413
    Abstract: Disclosed in the present invention are an acrylanilide compound represented by general formula (I) and a pharmaceutically acceptable salt thereof. The acrylanilide compound and the pharmaceutically acceptable salt thereof are used for treating clinical diseases by mainly acting on EGFR family casein kinases.
    Type: Application
    Filed: December 30, 2016
    Publication date: January 17, 2019
    Inventors: Jutong Si, Guan Wang, Zhihe Yang, Meifeng Jiang, Benpo Xu, Chentao Zhou