Patents by Inventor Zhihong Nie
Zhihong Nie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11513051Abstract: The present invention discloses a shale stress sensitivity testing device and method. The testing device comprises a support table. The left and right ends of the upper surface of the support table are respectively provided with a left side plate and a right side plate. The top of the left and right side plates are connected with the left and right ends of the top plate. The chucks of the clamps are capable of reciprocating motion in the horizontal direction and circular motion in the front-rear direction. The present invention can change the intensity and direction of the effective stress of the rock sample, and determine the permeability of the rock sample under different effective stresses, thus enabling comprehensive testing of the stress sensitivity of shale in different directions and enhancing the accuracy of shale stress sensitivity testing.Type: GrantFiled: June 30, 2022Date of Patent: November 29, 2022Assignee: Southwest Petroleum UniversityInventors: Mingqiang Wei, Yonggang Duan, Quantang Fang, Zhenglan Li, Le Luo, Keyi Ren, Xin Wang, Shuxin Li, Zhihong Nie
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Publication number: 20220250147Abstract: Provided are methods for preparing iron nanoparticles and to iron nanoparticles produced by those methods. The invention also provides methods for coating the iron nanoparticles with oxides and functionalizing the iron nanoparticles with organic and polymeric ligands. Additionally, the invention provides methods of using such iron nanoparticles.Type: ApplicationFiled: March 1, 2022Publication date: August 11, 2022Applicants: University of Maryland, College Park, University of Maryland, BaltimoreInventors: Zhihong NIE, Radi MASRI
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Patent number: 11285539Abstract: Provided are methods for preparing iron nanoparticles and to iron nanoparticles produced by those methods. The invention also provides methods for coating the iron nanoparticles with oxides and functionalizing the iron nanoparticles with organic and polymeric ligands. Additionally, the invention provides methods of using such iron nanoparticles.Type: GrantFiled: May 12, 2017Date of Patent: March 29, 2022Assignees: University of Maryland, College Park, University of Maryland, BaltimoreInventors: Zhihong Nie, Radi Masri
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Patent number: 10465723Abstract: A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet.Type: GrantFiled: October 10, 2016Date of Patent: November 5, 2019Assignee: President and Fellows of Harvard CollegeInventors: Filip Ilievski, Xin Chen, Aaron D. Mazzeo, George M. Whitesides, Robert F. Shepherd, Ramses V. Martinez, Won Jae Choi, Sen Wai Kwok, Stephen A. Morin, Adam Stokes, Zhihong Nie
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Publication number: 20190125672Abstract: The present invention is directed to compositions useful in assembling vesicles. The composition comprises a first block copolymer; a plurality of first inorganic nanoparticles; a second block copolymer; and a plurality of second inorganic nanoparticles or a plurality of small molecules. The composition is characterized by the ability to self-assemble into a vesicle. Also provided is a method of making a composition for delivery of a therapeutic agent and a method of using the vesicles as imaging agents.Type: ApplicationFiled: October 29, 2018Publication date: May 2, 2019Applicant: University of Maryland, College ParkInventors: Zhihong NIE, Yijing LIU, Kuikun YANG
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Publication number: 20190118265Abstract: Provided are methods for preparing iron nanoparticles and to iron nanoparticles produced by those methods. The invention also provides methods for coating the iron nanoparticles with oxides and functionalizing the iron nanoparticles with organic and polymeric ligands. Additionally, the invention provides methods of using such iron nanoparticles.Type: ApplicationFiled: May 12, 2017Publication date: April 25, 2019Applicant: University of Maryland, College ParkInventors: Zhihong NIE, Radi MASRI
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Publication number: 20170097021Abstract: A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet.Type: ApplicationFiled: October 10, 2016Publication date: April 6, 2017Inventors: Filip ILIEVSKI, Xin CHEN, Aaron D. MAZZEO, George M. WHITESIDES, Robert F. SHEPHERD, Ramses V. MARTINEZ, Won Jae CHOI, Sen Wai KWOK, Stephen A. MORIN, Adam STOKES, Zhihong NIE
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Patent number: 9594051Abstract: The multiplexed electrochemical microfluidic paper-based analytical device comprises multiple detection zones for the detection of multiple biochemical analytes from one single sample. Cavity valves integrated on the device will deliver the sample to different detection zones. These analytes include, but are not limited to, urea, creatinine, creatine, glucose, lactate, ethanol, uric acid, cholesterol, pyruvate, creatinine, ?-hydroxybutyrate, alanine aminotrasferase, aspartate aminotransferase, alkaline phosphatase, and acetylcholinesterase (or its inhibitors). This system will provide a simple and low-cost POC approach to obtain quantitative and multiple biological information from one sample (e.g. one drop of blood).Type: GrantFiled: March 6, 2014Date of Patent: March 14, 2017Assignee: President and Fellows of Harvard CollegeInventors: George M. Whitesides, Xiujun Li, Frederique Deiss, Zhihong Nie, Xinyu Liu
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Patent number: 9464642Abstract: A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet.Type: GrantFiled: November 21, 2011Date of Patent: October 11, 2016Assignee: President and Fellows of Harvard CollegeInventors: Filip Ilievski, Xin Chen, Aaron D. Mazzeo, George M. Whitesides, Robert F. Shepherd, Ramses V. Martinez, Won Jae Choi, Sen W. Kwok, Stephen Morin, Adam Stokes, Zhihong Nie
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Patent number: 9192933Abstract: Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.Type: GrantFiled: March 8, 2010Date of Patent: November 24, 2015Assignee: President and Fellows of Harvard CollegeInventors: George M. Whitesides, Zhihong Nie, Christian Nijhuis, Xin Chen, Andres W. Martinez, Max Narovlyansky
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Publication number: 20140183059Abstract: The multiplexed electrochemical microfluidic paper-based analytical device comprises multiple detection zones for the detection of multiple biochemical analytes from one single sample. Cavity valves integrated on the device will deliver the sample to different detection zones. These analytes include, but are not limited to, urea, creatinine, creatine, glucose, lactate, ethanol, uric acid, cholesterol, pyruvate, creatinine, ?-hydroxybutyrate, alanine aminotrasferase, aspartate aminotransferase, alkaline phosphatase, and acetylcholinesterase (or its inhibitors). This system will provide a simple and low-cost POC approach to obtain quantitative and multiple biological information from one sample (e.g. one drop of blood).Type: ApplicationFiled: March 6, 2014Publication date: July 3, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: George M. WHITESIDES, Xiujun LI, Frederique DEISS, Zhihong NIE, Xinyu LIU
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Publication number: 20140109560Abstract: A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet.Type: ApplicationFiled: November 21, 2011Publication date: April 24, 2014Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Filip Ilievski, Xin Chen, Aaron D. Mazzeo, George M. Whitesides, Robert F. Shepherd, Ramses V. Martinez, Won Jae Choi, Sen W. Kwok, Stephen A. Morin, Adam Stokes, Zhihong Nie
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Patent number: 8696952Abstract: The present invention provides a method and apparatus for producing polymeric particles with pre-designed size, shape, morphology and composition, and more particularly the present invention uses a microfluidic polymerization reactor for producing same. The present invention disclosed herein provides a process for producing polymer particles with pre-selected shapes. The method includes injecting a first fluid comprising a polymerizable constituent with a controlled flow rate into a microfluidic channel and injecting a second fluid with a controlled flow rate into the microfluidic channel in which the second fluid mixes with the first fluid, the second fluid being immiscible with the first fluid so that the first fluid forms into droplets in the microfluidic channel. The microfluidic channel has pre-selected dimensions to give droplets of pre-selected size, morphology and shape.Type: GrantFiled: April 25, 2005Date of Patent: April 15, 2014Inventors: Eugenia Kumacheva, Shengqing Xu, Zhihong Nie, Min Seok Seo, Patrick Cameron Lewis, Hong Zhang
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Publication number: 20120181184Abstract: Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.Type: ApplicationFiled: March 8, 2010Publication date: July 19, 2012Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: George M. Whitesides, Zhihong Nie, Christian Nijhuis, Xin Chen, Andres W. Martinez, Max Narovlyansky
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Publication number: 20110129941Abstract: The present invention provides a method and apparatus for producing polymeric particles with pre-designed size, shape, morphology and composition, and more particularly the present invention uses a microfluidic polymerization reactor for producing same. The present invention disclosed herein provides a process for producing polymer particles with pre-selected shapes. The method includes injecting a first fluid comprising a polymerizable constituent with a controlled flow rate into a microfluidic channel and injecting a second fluid with a controlled flow rate into the microfluidic channel in which the second fluid mixes with the first fluid, the second fluid being immiscible with the first fluid so that the first fluid forms into droplets in the microfluidic channel. The microfluidic channel has pre-selected dimensions to give droplets of pre-selected size, morphology and shape.Type: ApplicationFiled: April 25, 2005Publication date: June 2, 2011Inventors: Eugenia Kumacheva, Shengqing Xu, Zhihong Nie, Min Seok Seo, Patrick Cameron Lewis, Hong Zhang
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Publication number: 20070054119Abstract: The present invention generally relates to systems and methods of forming particles and, in certain aspects, to systems and methods of forming particles that are substantially monodisperse. Microfluidic systems and techniques for forming such particles are provided, for instance, particles may be formed using gellation, solidification, and/or chemical reactions such as cross-linking, polymerization, and/or interfacial polymerization reactions. In one aspect, the present invention is directed to a plurality of particles having an average dimension of less than about 500 micrometers and a distribution of dimensions such that no more than about 5% of the particles have a dimension greater than about 10% of the average dimension, which can be made via microfluidic systems. In one set of embodiments, at least some of the particles may comprise a metal, and in certain embodiments, at least some of the particles may comprise a magnetizable material.Type: ApplicationFiled: March 3, 2006Publication date: March 8, 2007Inventors: Piotr Garstecki, Douglas Weibel, Irina Gitlin, Shoji Takeuchi, Shengqing Xu, Zhihong Nie, Min Seo, Patrick Lewis, Eugenia Kumacheva, Howard Stone, George Whitesides