Patents by Inventor Zhihui He

Zhihui He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZOTHIAZOLE MEROTERPENOID COMPOUND AND DERIVATIVE THEREOF, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    Publication number: 20230373938
    Abstract: A benzothiazole meroterpenoid compound derived from deep sea fungi and a derivative thereof, and a preparation method therefor and the use thereof in the preparation of an anti-tumor drug are provided. The benzothiazole meroterpenoid compound is a compound as represented by formulas I to III or a salt thereof. The compound is isolated from a fermentation product of deep-sea-derived Penicillium allii-sativi and inhibits the transcriptional activity of an anti-tumor target RXRalpha by means of binding thereto so as to achieve a remarkable anti-tumor effect. The compound can be used for preparing, researching and developing anti-cancer drugs, and has good application prospects.
    Type: Application
    Filed: March 18, 2021
    Publication date: November 23, 2023
    Applicant: THIRD INSTITUTE OF OCEANOGRAPHY, MINISTRY OF NATURAL RESOURCES
    Inventors: Xianwen YANG, Chunlan XIE, Qingxiang YAN, Zhenbiao ZOU, Zhihui HE
  • Streptomyces and method for producing milbemycin A4 using same
    Patent number: 10526668
    Abstract: Provided are a Streptomyces (Streptomyces hygroscopicus) HS7522 and a method for preparing milbemycin A4 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7522 of the present invention is deposited in “China General Microbiological Culture Collection Center” with an accession number of CGMCC No. 9671 on Sep. 16, 2014.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: January 7, 2020
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Yun Teng, Meidong Xu, Meiyi Mo, Zhihui He, Zhengjie Chen, Lianiqing Jiang, Hua Bai
  • and method for producing milbemycin A3 using same
    Patent number: 10287545
    Abstract: Provided are a Streptomyces (Streptomyces hygroscopicus) HS7523 and a method for preparing milbemycin A3 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7523 is deposited in “China General Microbiological Culture Collection Center” with an accession number of CGMCC No. 9672 on Sep. 16, 2014.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: May 14, 2019
    Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Yun Teng, Meidong Xu, Meiyi Mo, Zhihui He, Zhengjie Chen, Lianiqing Jiang, Hua Bai
  • STREPTOMYCES AND METHOD FOR PRODUCING MILBEMYCIN A4 USING SAME
    Publication number: 20190048427
    Abstract: Provided are a Streptomyces (Streptomyces hygroscopicus) HS7522 and a method for preparing milbemycin A4 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7522 of the present invention is deposited in “China General Microbiological Culture Collection Center” with an accession number of CGMCC No. 9671 on Sep. 16, 2014.
    Type: Application
    Filed: March 25, 2016
    Publication date: February 14, 2019
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Yun Teng, Meidong Xu, Meiyi Mo, Zhihui He, Zhengjie Chen, Lianiqing Jiang, Hua Bai
  • MULTIFUNCTIONAL WORKING LIGHT
    Publication number: 20180202617
    Abstract: The present invention relates to a multifunctional working light, comprising a light tube and a light-emitting plate. The light-emitting plate is installed in the light tube. One end of the light tube is axially rotatably connected with a rotating sleeve. The end connected with the rotating sleeve is axially connected with a handle body. A fixed rocker arm is rotatably connected to a side wall of the handle body. Suction magnets are installed on an end surface of a free end of the fixed rocker arm. A hook is installed in the side wall of the handle body. A lower end of the hook is connected with the handle body through a ball body. The other end of the light tube is axially connected with a connecting sleeve.
    Type: Application
    Filed: March 16, 2018
    Publication date: July 19, 2018
    Inventor: ZHIHUI HE
  • STREPTOMYCES AND METHOD FOR PRODUCING MILBEMYCIN A3 USING SAME
    Publication number: 20180171283
    Abstract: Provided are a Streptomyces (Streptomyces hygroscopicus) HS7523 and a method for preparing milbemycin A3 by culturing the Streptomyces. The Streptomyces (Streptomyces hygroscopicus) HS7523 is deposited in “China General Microbiological Culture Collection Center” with an accession number of CGMCC No. 9672 on Sep. 16, 2014.
    Type: Application
    Filed: March 25, 2016
    Publication date: June 21, 2018
    Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.
    Inventors: Yun Teng, Meidong Xu, Meiyi Mo, Zhihui He, Zhengjie Chen, Lianiqing Jiang, Hua Bai