Abstract: The present invention belongs to the technical field of biomedicine, and mainly relates to a miR-7-5p mimic for inhibiting migration and invasion of breast cancer, a screening method and an application thereof. The sequence of the miR-7-5p is shown in SEQ ID NO.1. The present invention has found that the miR-7-5p mimic generates a significant inhibitory effect on breast cancer through targeted inhibition of the molecular mechanism of RYK. In vitro culture system, the miR-7-5p mimic can function to inhibit migration and invasion capabilities of breast cancer. The miR-7-5p mimic can inhibit RYK protein and mRNA levels in breast cancer. In nude mice, the miR-7-5p mimic can also significantly inhibit migration and invasion capabilities of breast cancer. Therefore, the present invention demonstrates that the miR-7-5p mimic can be a small-nucleic-acid drug to significantly inhibit breast cancer metastasis.

Abstract: The present disclosure belongs to the technical field of biomedicine, and in particular relates to a graphene oxide (GO)-based composite nanoparticle drug delivery system for treating cervical cancer and a preparation method thereof. The composite nanoparticle drug delivery system includes an aptamer NH2-AS1411 (Aptamer NH2-AS1411, APT), monolayer graphene oxide (GO), chitosan oligosaccharide (CO) and ?-polyglutamic acid (?-PGA).

Abstract: A copper ion-complexed poly gamma-glutamic acid (?-PGA)/chitosan (CS)/cotton blended antibacterial knitted fabric and a preparation method includes chitosan that is crosslinked with poly gamma-glutamic acid, then a copper-ammonia complex ion solution is added to prepare a spinning solution. The spinning solution is wet spun and then stretched, washed with water, finished, washed with water, and dried to get copper ion-complexed poly gamma-glutamic acid/chitosan composite fibers. The blended antibacterial knitted fabric is then prepared by using cotton fiber yarns and the composite fibers. There is a very high coordination coefficient between carboxyl groups of gamma-PGA and amino groups of CS, so the structure is stable. Poly-gamma glutamic acid can be used as water-retaining agent and heavy metal ion adsorbent, which can increase the loading rate of copper ions.

Abstract: The present disclosure belongs to the technical field of medicine preparation, and particularly relates to a nasal spray for preventing influenza based on a red pepper extract and heparin and a preparation method thereof. A nasal spray consists of the following raw materials in parts by weight: 10% ?-PGA-CS, 5-10% glycerol, 2% red pepper extract, 5-10% heparin solution, 2-2.4% ethanol and balance of purified water. The present disclosure can not only inhibit germs and diminish inflammation, and has a better therapeutic effect on rhinitis, but also can keep the inner surface of a nasal cavity moist for a long time. Moreover, the present disclosure can reduce side effects on a human body by changing the type of bactericides in the nasal spray, thus keeping the nasal cavity clean and moist for a long time.

Abstract: The present disclosure relates to the technical field of food supplement application, in particular to a high-intensity outdoor sports food supplement rich in biological ions and a preparation method thereof. The sports food supplement is prepared using the following components: poly-?-glutamic acid, magnesium sulfate, sodium carbonate, ammonium bicarbonate, potassium magnesium aspartate, potassium chloride, sodium citrate, potassium citrate, hydroxide calcium, zinc sulfate, antioxidant, preservative, Schisandra chinensis extraction solution, and water. The present disclosure promotes faster recovery of middle-aged men during exercise, reduces the risk of injury, and improves the ability of high-intensity running. The concentrated solution provided by the present disclosure has no bitter taste, a slightly sweet and refreshing taste, good palatability and good stability.

Abstract: A copper ion-complexed poly gamma-glutamic acid (?-PGA)/chitosan (CS)/cotton blended antibacterial knitted fabric and a preparation method includes chitosan that is crosslinked with poly gamma-glutamic acid, then a copper-ammonia complex ion solution is added to prepare a spinning solution. The spinning solution is wet spun and then stretched, washed with water, finished, washed with water, and dried to get copper ion-complexed poly gamma-glutamic acid/chitosan composite fibers. The blended antibacterial knitted fabric is then prepared by using cotton fiber yarns and the composite fibers. There is a very high coordination coefficient between carboxyl groups of gamma-PGA and amino groups of CS, so the structure is stable. Poly-gamma glutamic acid can be used as water-retaining agent and heavy metal ion adsorbent, which can increase the loading rate of copper ions.