Abstract: The present invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a 1-aminobenzo[4,5]imidazo[1,2-a]pyrazine-3-formamide compound, and the preparation therefor and use thereof. The structure of the compound of the present invention is as shown in formula (I). The compound has a novel structure and is an adenosine receptor inhibitor, has good inhibitory activity on adenosine A2A receptors, has good subtype selectivity, and can be used as a targeted adenosine A2A receptor inhibitor for immunotherapy. By means of inhibiting the activity of the adenosine A2A receptor, the function of removing tumor cells by the immune system is released, so that the effect of treating tumors is achieved.

Abstract: The embodiments of the present disclosure provide a physical digital twin modeling method and apparatus for an assembly, an electronic device and a medium. The physical digital twin modeling method for the assembly includes: generating a geometric distribution error surface of an assembly surface of a part; establishing an ideal model of the part without the geometric distribution error surface; integrating the geometric distribution error surface with the ideal model to establish a geometric distribution error integrated model of the part; assembling the geometric distribution error integrated model on a computer to establish a geometric digital twin model; and adding physical conditions to the geometric digital twin model of the assembly to establish a physical digital twin model of the assembly.

Abstract: Various examples of the present disclosure provide a manufacturing system and method for providing a variable pressure environment, which are applied to additive manufacturing and subtractive manufacturing, such as metal-based additive and subtractive manufacturing, hybrid additive and subtractive manufacturing, or ultrasonic hybrid additive manufacturing, etc. According to the examples of the present disclosure, a variable pressure environment is provided within the seal pressure vessel so as to implement the manufacturing process in the hyperbaric pressure environment. Thus, for a manufacturing process using metals as raw materials, various issues caused by metallurgical defects of the metals can be effectively suppressed. The storage vessel of the inert gas is safe and stable to the hyperbaric pressure environment, so that a manufacturing process applying a continuous and uniform hyperbaric pressure is achieved.

Abstract: The present disclosure provides a method for constructing a three-dimensional solid model with a geometric error and a computer-readable storage medium. The method includes: S10: obtaining an ideal geometric solid model of a component; S20: constructing a geometric error model for a surface of the component by use of geometric error data of the surface of the component; and S30: replacing a corresponding surface in the ideal geometric solid model with the geometric error model to obtain a three-dimensional solid model with a geometric error. The method for constructing a three-dimensional solid model provided by examples of the present disclosure integrates a geometric error of a component with a CAD model, so as to obtain a three-dimensional solid model with a geometric error, which describes a regular appearance characteristic of a real surface of the component macroscopically, and also reflects an irregular geometric error shape characteristic of the surface of the component microscopically.

Abstract: The present disclosure provides a method for constructing a three-dimensional solid model with a geometric error and a computer-readable storage medium. The method includes: S10: obtaining an ideal geometric solid model of a component; S20: constructing a geometric error model for a surface of the component by use of geometric error data of the surface of the component; and S30: replacing a corresponding surface in the ideal geometric solid model with the geometric error model to obtain a three-dimensional solid model with a geometric error. The method for constructing a three-dimensional solid model provided by examples of the present disclosure integrates a geometric error of a component with a CAD model, so as to obtain a three-dimensional solid model with a geometric error, which describes a regular appearance characteristic of a real surface of the component macroscopically, and also reflects an irregular geometric error shape characteristic of the surface of the component microscopically.