Abstract: Provided are a spiro-containing derivative, and a preparation method therefor and the use thereof. In particular, provided are a compound as shown in general formula (I), and a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the preparation of a drug for preventing and/or treating central nervous system diseases related to 5-hydroxytryptamine receptors and/or trace amine-related receptors and/or dopamine receptors in mammals.

Abstract: A manipulator a heated massaging function includes a main body. Two first massage assemblies are symmetrically arranged on two sides of the main body. The main body is provided with a driving mechanism and is further provided with a second massage assembly in a middle position between the two first massage assemblies. The second massage assembly includes a base, a first extension arm, a second extension arm, and at least two rolling heating assemblies. One end of the first extension arm and one end of the second extension arm are connected to the base in a swinging manner, and an elastic member is provided at a swing connection. The other end of the first extension arm and the other end of the second extension arm extend towards the upper and lower sides of the manipulator, respectively.