Patents by Inventor Zhili Xin

Zhili Xin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
    Publication number: 20060178400
    Abstract: The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
    Type: Application
    Filed: November 7, 2005
    Publication date: August 10, 2006
    Inventors: Bruce Beutel, Heidi Camp, Richard Clark, Yu-Gui Gu, Todd Hansen, Robert Keyes, Qun Li, Gang Liu, Hing Sham, Xiaojun Wang, Moshe Weitzberg, Zhili Xin, Xiangdong Xu, Tianyuan Zhang
  • Inhibitors of c-Jun N-terminal kinases
    Publication number: 20060173050
    Abstract: The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
    Type: Application
    Filed: January 23, 2006
    Publication date: August 3, 2006
    Inventors: Gang Liu, Hing Sham, Bruce Szczepankiewicz, Zhili Xin, Hongyu Zhao, Michael Serby, Bo Liu, Mei Liu
  • Isoxazole carboxamide derivatives as ghrelin receptor modulators
    Publication number: 20060089398
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
    Type: Application
    Filed: March 10, 2004
    Publication date: April 27, 2006
    Inventors: Gang Liu, Hongyu Zhao, Michael Serby, Bo Liu, Zhili Xin, Lissa Nelson, Bruce Szczepankiewicz, Hing Sham
  • Selective protein tyrosine phosphatatase inhibitors
    Patent number: 6972340
    Abstract: Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: December 6, 2005
    Assignee: Abbott Laboratories
    Inventors: Gang Liu, Bruce G. Szczepankiewicz, Zhonghua Pei, Zhili Xin, David A. Janowick
  • Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
    Publication number: 20050250768
    Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
    Type: Application
    Filed: August 20, 2004
    Publication date: November 10, 2005
    Inventors: James Link, Gang Liu, ZhongHua Pei, Tom Geldern, Martin Winn, Zhili Xin, Steven Boyd, Gui-Dong Zhu, Jennifer Freeman, Indrani Gunawardana, Michael Staeger, Hwan-Soo Jae, John Lynch, Sheldon Wang
  • Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists
    Publication number: 20050171132
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity and disorders associated with obesity such as non-insulin dependent diabetes mellitus.
    Type: Application
    Filed: September 23, 2004
    Publication date: August 4, 2005
    Inventors: Zhili Xin, Bo Liu, Gang Liu, Mei Liu, Michael Serby, Hongyu Zhao
  • Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists
    Publication number: 20050171131
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity, and disorders associated with obesity such as noninsulin dependent diabetes mellitus.
    Type: Application
    Filed: September 23, 2004
    Publication date: August 4, 2005
    Inventors: Christi Kosogof, Bo Liu, Gang Liu, Mei Liu, Lissa Nelson, Michael Serby, Hing Sham, Bruce Szczepankiewicz, Zhili Xin, Hongyu Zhao
  • Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
    Patent number: 6878700
    Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: April 12, 2005
    Assignee: Abbott Laboratories
    Inventors: James Link, Gang Liu, ZhongHua Pei, Tom von Geldern, Martin Winn, Zhili Xin, Steven A. Boyd, Gui-Dong Zhu, Jennifer C. Freeman, Indrani W. Gunawardana, Michael A. Staeger, Hwan-Soo Jae, John K. Lynch, Sheldon Wang
  • Pyrimidine derivatives as ghrelin receptor modulators
    Publication number: 20050070712
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
    Type: Application
    Filed: September 26, 2003
    Publication date: March 31, 2005
    Inventors: Christi Kosogof, Bo Liu, Gang Liu, Mei Liu, Lissa Nelson, Michael Serby, Hing Sham, Bruce Szczepankiewicz, Zhili Xin, Hongyu Zhao
  • Preparation of phosphorothioate oligomers
    Patent number: 6861518
    Abstract: Methods and Intermediates for the Preparation of Oligomers Containing Diastereomerically Enriched Phosphorothioate Linkages are Disclosed.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: March 1, 2005
    Assignee: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin, Jianchao Wang
  • Thienopyridones as AMPK activators for the treatment of diabetes and obesity
    Publication number: 20050038068
    Abstract: The present invention relates to compounds that activate AMP-activated protein kinase (AMPK), including the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders such as diabetes, metabolic syndrome, and obesity.
    Type: Application
    Filed: May 17, 2004
    Publication date: February 17, 2005
    Inventors: Rajesh Iyengar, Andrew Judd, Gang Zhao, Philip Kym, Hing Sham, Yugui Gu, Gang Liu, Mei Liu, Hongyu Zhao, Richard Clark, Ernst Frevert, Barbara Cool, Tianyuan Zhang, Robert Keyes, Todd Hansen, Zhili Xin
  • Tetraline derivatives as ghrelin receptor modulators
    Publication number: 20050014794
    Abstract: The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by ghrelin including anorexia, cancer cachexia, eating disorders, age-related decline in body composition, weight gain, obesity, and diabetes mellitus.
    Type: Application
    Filed: July 16, 2004
    Publication date: January 20, 2005
    Inventors: Bo Liu, Gang Liu, Lisa Nelson, Jyoti Patel, Hing Sham, Zhili Xin, Hongyu Zhao
  • Protein-tyrosine phosphatase inhibitors and uses thereof
    Publication number: 20040214870
    Abstract: The present invention is directed to compounds of formula (I), 1
    Type: Application
    Filed: February 4, 2004
    Publication date: October 28, 2004
    Inventors: Zhili Xin, Gang Liu, Zhonghua Pei, Bruce G. Szczepankiewicz, Michael D. Serby, Hongyu Zhao
  • Protein-tyrosine phosphatase inhibitors and uses thereof
    Publication number: 20040167188
    Abstract: The present invention is directed to compounds of formula (I), 1
    Type: Application
    Filed: February 14, 2003
    Publication date: August 26, 2004
    Inventors: Zhili Xin, Gang Liu, Zhonghua Pei, Bruce G. Szczepankiewicz, Michael D. Serby, Hongyu Zhao
  • Preparation of phosphorothioate oligomers
    Publication number: 20040097722
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
    Type: Application
    Filed: April 25, 2003
    Publication date: May 20, 2004
    Applicant: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin
  • Preparation of phosphorothioate oligomers
    Publication number: 20030229219
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
    Type: Application
    Filed: April 25, 2003
    Publication date: December 11, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin
  • Preparation of phosphorothioate oligomers
    Patent number: 6596857
    Abstract: Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: July 22, 2003
    Assignee: McGill University
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin
  • Preparation of phosphorothioate oligomers
    Publication number: 20030114660
    Abstract: Methods and Intermediates for the Preparation of Oligomers Containing Diastereomerically Enriched Phosphorothioate Linkages are Disclosed.
    Type: Application
    Filed: September 24, 2002
    Publication date: June 19, 2003
    Inventors: George Just, Zhili Xin, Eric Marsault, Yi Jin, Jianchao Wang
  • Selective protein tyrosine phosphatatase inhibitors
    Publication number: 20020169157
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: February 27, 2002
    Publication date: November 14, 2002
    Inventors: Gang Liu, Zhili Xin, Zhonghua Pei, Xiaofeng Li, Bruce G. Szczepankiewicz, David A. Janowick, Thorsten K. Oost
  • Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
    Patent number: RE39197
    Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: July 18, 2006
    Assignee: Abbott Laboratories
    Inventors: James T. Link, Gang Liu, Zhonghua Pei, Tom von Geldern, Martin Winn, Zhili Xin