Abstract: A method includes obtaining an image having M sections and each section having N pixels. The method further includes deriving N sub-images from the image, wherein each sub-image has M sections and each section has N pixels. The i-th pixel of the j-th section of the i-th sub-image has a pixel value equal to a pixel value of the i-th pixel of the j-th section of the image and other pixels of the j-th section of the i-th sub-image are set to 0, where i traverses from 1 to N, and j traverses from 1 to M. The method further includes providing N projection patterns and calculating a projection for each sub-image by performing convolution of the respective sub-image with a corresponding one of the projection patterns, thereby obtaining N projected sub-images. The method further includes summing up the N projected sub-images, thereby obtaining a projection of the image.

Abstract: A method includes providing a target object and acquiring measured images of the target object. Each of the measured images is acquired by filtering radiation from the target object by a mask having multiple holes and detecting filtered radiation by a detector. The method further includes providing an estimated image of the target object and calculating an updating factor for each of the measured images. The calculating of the updating factor includes partitioning a mathematical representation of the mask into multiple first regions; for each of the first regions, deriving a separate forward projection from the estimated image of the target object and the respective first region; and comparing the respective measured image of the target object with the forward projections. The method further includes updating the estimated image of the target object based on the updating factors.

Abstract: A method of imaging reconstruction includes providing a detector and a collimator, operating the detector to acquire a measured image of a target object from photons passing through the collimator, partitioning the collimator such that the collimator can be represented by a first matrix, providing an initial estimated image of the target object, and calculating an estimated image of the target object based on the measured image and the first matrix. The calculating of the estimated image includes an iteration using the initial estimated image as a starting point. The method also includes partitioning the collimator such that the collimator can be represented by a second matrix larger than the first matrix, and calculating a refined estimated image of the target object based on the measured image and the second matrix. The calculating of the refined estimated image includes an iteration using the estimated image as a starting point.

Abstract: A radiation-based imaging system includes a collimator configured to filter radiation emitted from a target object, the collimator including a plurality of apertures non-uniformly distributed on the collimator. A largest acceptance angle of the plurality of apertures is not larger than 15°. The radiation-based imaging system further includes a detector for detecting the radiation that has passed through the collimator. The collimator is spaced from the detector such that a point on a top surface of the detector that faces the collimator is simultaneously illuminated by two or more of the plurality of apertures.

Abstract: A breast imaging system for examining a breast on a chest of a patient comprises first one or more shielding devices configured for placement on a first side of the breast and a first collimator and a first detector configured for placement on the first side of the breast and at a position that is further away from the breast and from the chest than the first one or more shielding devices are.

Abstract: A method of imaging reconstruction includes providing a detector and a collimator, operating the detector to acquire a measured image of a target object from photons passing through the collimator, partitioning the collimator such that the collimator can be represented by a first matrix, providing an initial estimated image of the target object, and calculating an estimated image of the target object based on the measured image and the first matrix. The calculating of the estimated image includes an iteration using the initial estimated image as a starting point. The method also includes partitioning the collimator such that the collimator can be represented by a second matrix larger than the first matrix, and calculating a refined estimated image of the target object based on the measured image and the second matrix. The calculating of the refined estimated image includes an iteration using the estimated image as a starting point.

Abstract: According to various embodiments, the present disclosure provides a collimator for medical imaging. The collimator includes a perforated plate with a top surface and a bottom surface and holes distributed on the perforated plate. The holes are arranged in a plurality of groups. The plurality of groups forms a first coded aperture pattern and the holes in each of the plurality of groups form a second coded aperture pattern.

Abstract: A medical imaging system includes a collimator having a plurality of collimator parts configured to filter radiation emitted from a target object; a detector base; and a detector having a plurality of detector tiles, configured to acquire an image of the target object by detecting radiation that has passed through the plurality of collimator parts, wherein at least one of the plurality of detector tiles is tilted with respect to the detector base.

Abstract: A method includes providing a target object and acquiring measured images of the target object. Each of the measured images is acquired by filtering radiation from the target object by a mask having multiple holes and detecting filtered radiation by a detector. The method further includes providing an estimated image of the target object and calculating an updating factor for each of the measured images. The calculating of the updating factor includes partitioning a mathematical representation of the mask into multiple first regions; for each of the first regions, deriving a separate forward projection from the estimated image of the target object and the respective first region; and comparing the respective measured image of the target object with the forward projections. The method further includes updating the estimated image of the target object based on the updating factors.

Abstract: A medical imaging system includes a collimator configured to filter radiation emitted from a subject; and a detector configured to detector radiation that has passed through the collimator, wherein the detector includes a plurality of detector tiles and at least one detector tile is moveable with respect to other detector tiles, wherein top surfaces of the plurality of detector tiles are capable to be configured as being coplanar.

Abstract: According to various embodiments, the present disclosure provides a method of imaging reconstruction. The method of imaging reconstruction includes providing a target object, a detector, and a mask disposed between the target object and the detector; acquiring a measured image of the target object by the detector; providing an estimated image of the target object; partitioning the mask into multiple regions; for each of the regions, deriving a forward projection from the estimated image of the target object and the respective region, thereby acquiring multiple forward projections; comparing the measured image of the target object with the forward projections; and updating the estimated image of the target object based on a result of the comparing.

Abstract: A breast imaging system for examining a breast on a chest of a patient comprises first one or more shielding devices configured for placement on a first side of the breast and a first collimator and a first detector configured for placement on the first side of the breast and at a position that is further away from the breast and from the chest than the first one or more shielding devices are.

Abstract: A radiation-based imaging system includes a collimator configured to filter radiation emitted from a target object, the collimator including a plurality of apertures non-uniformly distributed on the collimator. A largest acceptance angle of the plurality of apertures is not larger than 15°. The radiation-based imaging system further includes a detector for detecting the radiation that has passed through the collimator. The collimator is spaced from the detector such that a point on a top surface of the detector that faces the collimator is simultaneously illuminated by two or more of the plurality of apertures.

Abstract: A medical imaging system includes a first collimator configured to filter radiation emitted from a subject, a first detector configured to detect radiation that has passed through the first collimator, a second collimator configured to filter radiation emitted from the subject, wherein the first collimator partially blocks a field of view (FOV) of the second collimator, and a second detector configured to detect radiation that has passed through the second collimator.

Abstract: A medical imaging system includes a collimator configured to filter radiation emitted from a subject; and a detector configured to detector radiation that has passed through the collimator, wherein the detector includes a plurality of detector tiles and at least one detector tile is moveable with respect to other detector tiles, wherein top surfaces of the plurality of detector tiles are capable to be configured as being coplanar.

Abstract: According to various embodiments, the present disclosure provides a collimator for medical imaging. The collimator includes a perforated plate with a top surface and a bottom surface and holes distributed on the perforated plate. The holes are arranged in a plurality of groups. The plurality of groups forms a first coded aperture pattern and the holes in each of the plurality of groups form a second coded aperture pattern.

Abstract: According to various embodiments, the present disclosure provides a method of imaging reconstruction. The method of imaging reconstruction includes providing a target object, a detector, and a mask disposed between the target object and the detector; acquiring a measured image of the target object by the detector; providing an estimated image of the target object; partitioning the mask into multiple regions; for each of the regions, deriving a forward projection from the estimated image of the target object and the respective region, thereby acquiring multiple forward projections; comparing the measured image of the target object with the forward projections; and updating the estimated image of the target object based on a result of the comparing.

Abstract: A medical imaging system includes a first collimator configured to filter radiation emitted from a subject, a first detector configured to detect radiation that has passed through the first collimator, a second collimator configured to filter radiation emitted from the subject, wherein the first collimator partially blocks a field of view (FOV) of the second collimator, and a second detector configured to detect radiation that has passed through the second collimator.

Abstract: A method includes providing a set of 2D images of an object, wherein the set of 2D images is obtained from a three-dimensional (3D) image of the object placed at a first pose. The method further includes projecting the set of 2D images from the first pose to a second pose different from the first pose, thereby obtaining a set of re-projected 2D images; and combining the set of re-projected 2D images into a single 2D image.

Abstract: A method includes providing a set of 2D images of an object, wherein the set of 2D images is obtained from a three-dimensional (3D) image of the object placed at a first pose. The method further includes projecting the set of 2D images from the first pose to a second pose different from the first pose, thereby obtaining a set of re-projected 2D images; and combining the set of re-projected 2D images into a single 2D image.