Patents by Inventor Zhiqi GE

Zhiqi GE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Primers, compositions, and methods for nucleic acid sequence variation detection
    Patent number: 11306350
    Abstract: Specific, accurate, and cost effective primers for performing digital PCR, compositions and kits containing the primer and methods for using and making the same are useful for detecting nucleic acid mutations. A primer useful as a first forward primer in performing digital PCR to detect a target nucleic acid in a sample, includes: a detection portion located upstream to a target sequence binding portion, and including a second forward primer binding portion having a sequence substantially complementary to a second forward primer, and a probe binding portion downstream to the second forward primer binding portion having a sequence substantially complementary to a probe; the target sequence binding portion includes a mismatch portion having a sequence not complementary to the target nucleic acid, and an amplification determinant portion downstream to the mismatch portion having a sequence complementary to a gene allele or a variant thereof encoded by the target nucleic acid.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: April 19, 2022
    Assignee: Maccura Biotechnology Co., Ltd.
    Inventors: Yuhang Zhao, Shufang Wang, Zhiqi Ge
  • PRIMERS, COMPOSITIONS, AND METHODS FOR NUCLEIC ACID SEQUENCE VARIATION DETECTION
    Publication number: 20200102606
    Abstract: Specific, accurate, and cost effective primers for performing digital PCR, compositions and kits containing the primer and methods for using and making the same are useful for detecting nucleic acid mutations. A primer useful as a first forward primer in performing digital PCR to detect a target nucleic acid in a sample, includes: a detection portion located upstream to a target sequence binding portion, and including a second forward primer binding portion having a sequence substantially complementary to a second forward primer, and a probe binding portion downstream to the second forward primer binding portion having a sequence substantially complementary to a probe; the target sequence binding portion includes a mismatch portion having a sequence not complementary to the target nucleic acid, and an amplification determinant portion downstream to the mismatch portion having a sequence complementary to a gene allele or a variant thereof encoded by the target nucleic acid.
    Type: Application
    Filed: April 15, 2019
    Publication date: April 2, 2020
    Applicant: Maccura Biotechnology Co., Ltd.
    Inventors: Yuhang ZHAO, Shufang WANG, Zhiqi GE