Patents by Inventor Zhiqiang Cai

Zhiqiang Cai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200165333
    Abstract: Provided herein are isolated antibodies or antibody fragments thereof that immunospecifically bind to platelet factor 4 (PF4). In some embodiments the isolated antibodies or antigen-binding fragments thereof comprise a light chain CDR and framework region comprising SEQ ID NO: 4 and a heavy chain CDR and framework region comprising SEQ ID NO: 10. Also provided herein are methods for treating heparin-induced thrombocytopenia (HIT) and methods for reducing the likelihood that subject will become afflicted with HIT. Further disclosed are uses of the isolated antibodies or antibody fragments in the treatment of HIT or the manufacture of compositions for the treatment of HIT.
    Type: Application
    Filed: May 11, 2018
    Publication date: May 28, 2020
    Inventors: Mark I. GREENE, Zheng CAI, Zhiqiang ZHU, Douglas B. CINES
  • Publication number: 20200131192
    Abstract: Disclosed are imidazo[1,2-b]pyrimido[4,5-d]pyridazin-5(6H)-one compounds, specifically represented by the Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein A and R1-R5 are defined herein. Compounds having Formula I are Wee1 kinase inhibitors. Therefore, compounds of the disclosure may be used to treat diseases caused by abnormal Wee1 activity.
    Type: Application
    Filed: July 10, 2018
    Publication date: April 30, 2020
    Applicant: IMPACT THERAPEUTICS, INC.
    Inventors: Suixiong CAI, Ye Edward TIAN, Zhiqiang DONG, Xiaozhu WANG
  • Publication number: 20200003786
    Abstract: The present invention provides a humanized antibody or antibody fragment comprising (a) a humanized light chain comprising 1) Complementarity Determining Region (CDR)-L1, the sequence of which is identical to the sequence of SEQ ID NO: 3; 2) CDR-L2, the sequence of which is identical to the sequence of SEQ ID NO: 4; and 3) CDR-L3, the sequence of which is identical to the sequence of SEQ ID NO: 5, and (b) a humanized heavy chain comprising 1) CDR-H1, the sequence of which is identical to the sequence of SEQ ID NO: 6; 2) CDR-H2, the sequence of which is identical to the sequence of SEQ ID NO: 7; and 3) CDR-H3, the sequence of which is identical to the sequence of SEQ ID NO: 8, as well as methods for treating, diagnosing, and monitoring the progression of HIT. The present invention also provides methods for assessing the antigenicity and ability to cause HIT of anionic anticoagulants.
    Type: Application
    Filed: June 20, 2019
    Publication date: January 2, 2020
    Inventors: Mark I. Greene, Douglas B. Cines, Zheng Cai, Zhiqiang Zhu
  • Patent number: 10371705
    Abstract: The present invention provides a humanized antibody or antibody fragment comprising (a) a humanized light chain comprising 1) Complementarity Determining Region (CDR)-L1, the sequence of which is identical to the sequence of SEQ ID NO: 3; 2) CDR-L2, the sequence of which is identical to the sequence of SEQ ID NO: 4; and 3) CDR-L3, the sequence of which is identical to the sequence of SEQ ID NO: 5, and (b) a humanized heavy chain comprising 1) CDR-H1, the sequence of which is identical to the sequence of SEQ ID NO: 6; 2) CDR-H2, the sequence of which is identical to the sequence of SEQ ID NO: 7; and 3) CDR-H3, the sequence of which is identical to the sequence of SEQ ID NO: 8, as well as methods for treating, diagnosing, and monitoring the progression of HIT. The present invention also provides methods for assessing the antigenicity and ability to cause HIT of anionic anticoagulants.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: August 6, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Douglas B. Cines, Zheng Cai, Zhiqiang Zhu
  • Patent number: 10295737
    Abstract: The present invention relates to the field of single-mode optical fibers and discloses a bending-insensitive, radiation-resistant single-mode optical fiber, sequentially including from inside to outside: a core, inner claddings, and an outer cladding, all made from a quartz material. The inner claddings comprise, from inside to outside, a first fluorine-doped inner cladding and a second fluorine-doped inner cladding. The core and the first fluorine-doped inner cladding are not doped with germanium. The respective concentrations of other metal impurities and phosphorus are less than 0.1 ppm. By mass percent, the core has a fluorine dopant content of 0-0.45% and a chlorine content of 0.01-0.10%; the first fluorine-doped inner cladding has a fluorine concentration of 1.00-1.55%; and the second fluorine-doped inner cladding has a fluorine concentration of 3.03-5.00%.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: May 21, 2019
    Assignee: FIBERHOME TELECOMMUNICATION TECHNOLOGIES CO., LTD
    Inventors: Qi Mo, Lijie Huang, Huang Yu, Cheng Liu, Wen Chen, Zhiqiang Yu, Dongxiang Wang, Bingfeng Cai, Liming Chen, Huiping Shi
  • Publication number: 20160012123
    Abstract: One aspect of the invention provides a method of evaluating semantic differences between a first item in a first semantic space and a second item in a second semantic space. Thee method includes: calculating a first ordered list of N nearest neighbors of the first item within the first semantic space; calculating a second ordered list of N nearest neighbors of the second item within the second semantic space; and computing a plurality of similarity measures between the first n nearest neighbors of the first item and the first n nearest neighbors of the second item, wherein n and N are positive integers and 1?n?N.
    Type: Application
    Filed: September 9, 2015
    Publication date: January 14, 2016
    Inventors: Xiangen Hu, Zhiqiang Cai, Arthur C. Graesser, Scotty Craig
  • Patent number: 9158841
    Abstract: One aspect of the invention provides a method of evaluating semantic differences between a first item in a first semantic space and a second item in a second semantic space. The method includes: calculating a first ordered list of N nearest neighbors of the first item within the first semantic space; calculating a second ordered list of N nearest neighbors of the second item within the second semantic space; and computing a plurality of similarity measures between the first n nearest neighbors of the first item and the first n nearest neighbors of the second item, wherein n and N are positive integers and 1?n?N.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: October 13, 2015
    Assignee: The University of Memphis Research Foundation
    Inventors: Xiangen Hu, Zhiqiang Cai, Arthur C. Graesser, Scotty Craig
  • Publication number: 20130138665
    Abstract: One aspect of the invention provides a method of evaluating semantic differences between a first item in a first semantic space and a second item in a second semantic space. Thee method includes: calculating a first ordered list of N nearest neighbors of the first item within the first semantic space; calculating a second ordered list of N nearest neighbors of the second item within the second semantic space; and computing a plurality of similarity measures between the first n nearest neighbors of the first item and the first n nearest neighbors of the second item, wherein n and N are positive integers and 1?n?N.
    Type: Application
    Filed: June 14, 2012
    Publication date: May 30, 2013
    Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: Xiangen Hu, Zhiqiang Cai, Arthur C. Graesser, Scotty Craig
  • Patent number: D859620
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: September 10, 2019
    Assignee: Guangdong Shunde Noon Appliance Manufacturing Co., Ltd.
    Inventors: Jinliang Le, Zhiqiang Pan, Chao Shang, Xianhao Cai