Abstract: The present disclosure relates to novel alpha2 adrenergic receptor (?2AR) agonists and uses thereof. In particular, the present disclosure relates to imidazole containing compounds, in particular, of formula (I-A), formula (I-B), formula (I-C), formula (I-D), or formula (II). These compounds can be useful as peripherally selective ?2AR agonists for the treatment or prevention of disease thereof.

Abstract: Surface structures that enable the preparation of three-dimensional microarrays of proteins or small molecules or other types of macromolecules are disclosed. The three-dimensional microarrays possess higher sensitivity for detecting protein-macromolecule and small molecule-protein interactions in a high-throughput fashion.

Abstract: The present invention relates to the method and the system for initializing secure network access for POS terminals. Said system comprises a terminal backend system and a POS terminal. The POS terminal is provided with: a security module, which was preloaded with a terminal default public key certificate, a private key file, and a CA public key certificate of the terminal backend system in the setting of leaving the factory; a transaction module, which is used for performing the acquiring operation with the following core trading module; and a parameter initializing module, which is used for implementing network access.

Abstract: Disclosed is an operation amplification circuit and an over-current protection method therefor. The operation amplification circuit comprises: a control unit, configured to generate an output control signal according to an input signal and an output signal; an output unit, configured to generate an output current under control of the output control signal, wherein the output unit comprises an output capacitor which is charged or discharged by the output current to generate the output signal; an over-current protection unit, obtaining a temperature control current according to an operating temperature of the operation amplification circuit, wherein when the operating temperature is greater than or equal to a predetermined temperature, the temperature control current is positively correlated with the operating temperature, and the over-current protection unit adjusts the output control signal according to the temperature control current to limit the output current.

Abstract: Disclosed an LED driving controller and a driving circuit. The LED driving controller comprises: a power transistor having a control terminal for receiving a switching control signal, a first terminal and a second terminal; zero-crossing detection circuit for generating a zero-crossing detection signal; a first comparison circuit, configured to compare a reference voltage with a sampling voltage to generate a first control signal; a control circuit being coupled to the zero-crossing detection circuit and the comparison circuit and configured to generate a switching control signal in accordance with the zero-crossing detection signal and the first control signal; an overvoltage protection circuit configured to generate an overvoltage protection signal in accordance with an off-time provided by the control circuit and a reference voltage; a shielding circuit configured to shield the overvoltage protection signal is provided.

Abstract: Disclosed an LED driving controller and a driving circuit. The LED driving controller comprises: a power transistor having a control terminal for receiving a switching control signal, a first terminal and a second terminal; zero-crossing detection circuit for generating a zero-crossing detection signal; a first comparison circuit, configured to compare a reference voltage with a sampling voltage to generate a first control signal; a control circuit being coupled to the zero-crossing detection circuit and the comparison circuit and configured to generate a switching control signal in accordance with the zero-crossing detection signal and the first control signal; an overvoltage protection circuit configured to generate an overvoltage protection signal in accordance with an off-time provided by the control circuit and a reference voltage; a shielding circuit configured to shield the overvoltage protection signal is provided.

Abstract: Disclosed is an operation amplification circuit and an over-current protection method therefor. The operation amplification circuit comprises: a control unit, configured to generate an output control signal according to an input signal and an output signal; an output unit, configured to generate an output current under control of the output control signal, wherein the output unit comprises an output capacitor which is charged or discharged by the output current to generate the output signal; an over-current protection unit, obtaining a temperature control current according to an operating temperature of the operation amplification circuit, wherein when the operating temperature is greater than or equal to a predetermined temperature, the temperature control current is positively correlated with the operating temperature, and the over-current protection unit adjusts the output control signal according to the temperature control current to limit the output current.

Abstract: The present invention relates to the method and the system for initializing secure network access for POS terminals. Said system comprises a terminal backend system and a POS terminal. The POS terminal is provided with: a security module, which was preloaded with a terminal default public key certificate, a private key file, and a CA public key certificate of the terminal backend system in the setting of leaving the factory; a transaction module, which is used for performing the acquiring operation with the following core trading module; and a parameter initializing module, which is used for implementing network access.

Abstract: The present application discloses a secure transfer method for cloud-based POS transaction sensitive data, comprising steps of: (a) exchanging a transaction process key with the cloud POS terminal; (b) receiving, from the cloud POS terminal, the transaction request packet encrypted by using the transaction process key; and (c) obtaining the transaction sensitive data from the transaction request packet, and using the transaction process key to operate on the transaction sensitive data so as to upload to the financial acquiring platform. The present invention also discloses a secure transfer system for cloud-based POS transaction sensitive data.