Abstract: Disclosed are antibodies thereof that bind to coagulation factor XI (FXI) and/or its activated form factor XIa (FXIa), or to fragments of FXI and/or FXIa, and compositions containing the antibodies. Also disclosed are methods of preparing the antibodies and use of the antibodies for treating and/or preventing coagulation associated conditions such as thrombosis and complications or conditions associated with thrombosis.

Abstract: A whole-airspace satellite search method and device based on a phased array antenna are provided. The present disclosure combines electronic scanning implemented by the phased array antenna with mechanical scanning implemented by a mechanical actuator. As for low-orbit satellite communication, the present disclosure achieves rapid search and aiming through the phased array antenna, and solves the problem of limited electronic scanning angle of the phased array antenna through a servo system of the mechanical actuator. On the other hand, the present disclosure supports whole-airspace search and aiming of high, medium, and low-orbit satellites through the combination of the electronic scanning implemented by the phased array antenna and the mechanical scanning implemented by the mechanical actuator.

Abstract: This application provides a data transmission method and a terminal device, to reduce a data transmission latency and improve data transmission reliability. The method includes: obtaining, by a terminal device, a grant-free GF resource configured by a base station; obtaining, by the terminal device, current channel quality; and if the current channel quality is first channel quality, transmitting, by the terminal device, to-be-transmitted data by using the GF resource, or transmitting, by the terminal device, the to-be-transmitted data by using a GB resource, where the first channel quality falls within a first range; or if the current channel quality is second channel quality, skipping, by the terminal device, transmitting to-be-transmitted data by using the GF resource, where the second channel quality falls within a second range; where the first channel quality is better than the second channel quality, and the first range is different from the second range.

Abstract: Disclosed are single domain antibodies that specifically bind to human LAG3 or a fragment or functional domain thereof, and compositions containing the single domain antibodies. Also disclosed are methods of preparing the antibodies and use of the antibodies for treating and/or preventing one or more conditions such as lymphoma, non-small cell lung cancer (NSCLC), gastric cancer, hepatocellular carcinoma, renal cell carcinoma, bladder cancer, squamous cell carcinoma of the head and neck, melanoma, or glioblastoma.

Abstract: Disclosed herein are compositions comprising GLP-1 and/or GLP-1 analog(s) for treating or preventing non-alcoholic steatohepatitis (NASH).

Abstract: Disclosed herein are combinational therapies for diabetes comprising a first effective amount of one or more first active ingredients selected from the group consisting of GLP-1 and GLP-1 analogs and a second effective amount of one or more second active ingredients selected from the group consisting of insulin and insulin analogs.

Abstract: Disclosed herein are dosing regimens of GLP-1 and/or GLP-1 analog(s).

Abstract: A wireless network switching method. In the method, a station and a target access device directly generate a message integrity check key by means of a domain key, and verify an integrity code on the basis of the message integrity check key, so as to realize the authentication of two parties; and when the authentication of the opposite party is successful, session keys are generated by means of the domain key and in conjunction with random numbers of the two parties, thereby simplifying a switching process and realizing secure and efficient network switching. Further disclosed are a corresponding station and a corresponding access device.

Abstract: The present invention relates to the field of folding frames, and in particular, to a rivet riveting folding frame. While the rivet riveting folding frame realizes the bending for adjustment of angle, the movable connections are all realized by riveting of rivets, and all the riveting positions of rivets have arc transitions, so that the phenomenon that scratching by screws and nuts is prone to occur in the prior art is avoided, and young users can use them at ease. In addition, the rivet riveting adopted in the present invention can greatly reduce the processing difficulty and improve the assembly efficiency.

Abstract: A method for synthesizing lacto-N-biose and belongs to the technical field of bioengineering and oligosaccharide synthesis. A multi-enzyme catalytic system with good biological safety and wide application, and an ATP regeneration cycle system is introduced into a multi-enzyme reaction system, so that the synthesis of lacto-N-biose and the utilization rate of substrates are improved. A novel lacto-N-biose synthetic route lays a foundation for large-scale industrial production of lacto-N-biose and has important economic values and social benefits. At the same time, the synthetic method is efficient, mild, simple, easy to operate, low in cost and suitable for industrial production, and has a high practical application value.

Abstract: A method and device for managing a digital certificate are provided. A digital certificate requesting device negotiates with a digital certificate issuing device by using an acquired authorization code, to establish a security data channel and generate a security key, and messages can be encrypted with the generated data communication key during a process of message interaction between the digital certificate requesting device and the digital certificate issuing device, thereby effectively increasing the security in data transmission. The method and device are applicable for automatically requesting for, querying, updating, revoking a digital certificate and acquiring a digital certificate revocation list in various scenarios.

Abstract: The present invention discloses a branch optimization method for execution of a big data ETL model. The necessity of model execution can be analyzed according to the update characteristics of raw data sets and the characteristics of the ETL model; and optimization judgment is carried out on a plurality of operator branches of the ETL model, and for branches with lower update frequency, a middle repeated calculation process is skipped in a manner of reconstructing a cache table, so that the repeated execution rate is reduced from the operator aspect, the execution efficiency of the ETL model is improved, and the big data analysis is carried out more efficiently.

Abstract: The present invention discloses a ship wandering detection method based on AIS (Automatic Identification System) data. According to acquired AIS trajectory data of a ship, wandering behaviors of the ship are detected according to the massive trajectory data, the wandering behaviors of the ship are classified, and relationships between trajectories of four typical abnormal movement behaviors of the ship and defined variables are summarized. The detection for the wandering behaviors of the ship can provide decision support for maritime safety supervision, so as to enhance the safety of maritime traffic and ensure the safe navigation of the ship, which has great significance to promote the safety, efficiency and smoothness of maritime transportation.

Abstract: Provided in the present invention are a digital credential management method and a device, the method comprising: a digital credential application device negotiating establishment of a secure data channel with a digital credential issuing device, and sending to the digital credential issuing device a digital credential management request message; the digital credential issuing device receiving the message, and sending to the digital credential application device a digital credential management verification request message; the digital credential application device receiving the verification request message, and sending to the digital credential issuing device a digital credential management verification response message; the digital credential issuing device receiving the digital credential management verification response message, and sending to the digital credential application device a digital credential management response message; the digital credential application device receiving the digital credentia

Abstract: A method and device for managing a digital certificate are provided. A digital certificate requesting device negotiates with a digital certificate issuing device by using an acquired authorization code, to establish a security data channel and generate a security key, and messages can be encrypted with the generated data communication key during a process of message interaction between the digital certificate requesting device and the digital certificate issuing device, thereby effectively increasing the security in data transmission.

Abstract: Provided are an entity identity validity verification method and device with multiple trusted third parties being involved. In the application, validity of identities of entities performing mutual identity validity verification can only be verified by different trusted third parties. During the verification process, the trusted third parties that are respectively trusted by the two entities interact with each other, and provide identity validity verification services for mutual identity validity verification between the entities, to complete the identity validity verification between the entities.

Abstract: Provided in the present invention are a digital credential management method and a device, the method comprising: a digital credential application device negotiating establishment of a secure data channel with a digital credential issuing device, and sending to the digital credential issuing device a digital credential management request message; the digital credential issuing device receiving the message, and sending to the digital credential application device a digital credential management verification request message; the digital credential application device receiving the verification request message, and sending to the digital credential issuing device a digital credential management verification response message; the digital credential issuing device receiving the digital credential management verification response message, and sending to the digital credential application device a digital credential management response message; the digital credential application device receiving the digital credentia

Abstract: Provided are an entity identity validity verification method and device with multiple trusted third parties being involved. In the application, validity of identities of entities performing mutual identity validity verification can only be verified by different trusted third parties. During the verification process, the trusted third parties that are respectively trusted by the two entities interact with each other, and provide services for mutual identity validity verification between the entities, to complete the identity validity verification between the entities.

Abstract: Provided are an entity identity validity verification method and device with multiple trusted third parties being involved. In the application, validity of identities of entities performing mutual identity validity verification can only be verified by different trusted third parties. During the verification process, the trusted third parties that are respectively trusted by the two entities interact with each other, and provide services for mutual identity validity verification between the entities, to complete the identity validity verification between the entities.

Abstract: Provided are an entity identity validity verification method and device with multiple trusted third parties being involved. In the application, validity of identities of entities performing mutual identity validity verification can only be verified by different trusted third parties. During the verification process, the trusted third parties that are respectively trusted by the two entities interact with each other, and provide services for verifying validity of an identity of one entity by the other entity, to complete identity validity verification between the entities.