Patents by Inventor Zhiqiang Zhao
Zhiqiang Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180179190Abstract: The present invention relates to metallo-?-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and RB are as defined herein. The present invention also relates to compositions which comprise a metallo-?-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more ?-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.Type: ApplicationFiled: June 24, 2016Publication date: June 28, 2018Applicant: Marck Sharp & Dohme Corp.Inventors: Frank Bennett, Jinlong Jiang, Alexander Pasternak, Shuzhi Dong, Xin Gu, Jack D. Scott, Haiqun Tang, Zhiqiang Zhao, Yuhua Huang, David Hunter, Dexi Yang, Katherine Young, Li Xiao, Zhibo Zhang, Jianmin Fu, Yunfeng Bai, Zhixiang Zheng, Xu Zhang
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Publication number: 20180127913Abstract: A draining anti-siphon device has a water outlet pipe comprising a first water pipe and a second water pipe which are connected with each other, the pipe diameter of at least part of the second water pipe is larger than the pipe diameter of the first water pipe, one end of an air pipe is communicated with the second water pipe, and the communicating position of the air pipe and the second water pipe is located at a radial surface of the second water pipe, so that siphon reverse flow is prevented by means of a diameter changing structure of the air pipe and the water outlet pipe. In a washing machine, the draining anti-siphon device is mounted on a draining hose, the air pipe of the draining anti-siphon device is communicated with the outer drum of the washing machine.Type: ApplicationFiled: April 15, 2016Publication date: May 10, 2018Applicant: QINGDAO HAIER DRUM WASHING MACHINE CO., LTD.Inventors: Sheng XU, Zhiqiang ZHAO, Xiuwen PENG
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Publication number: 20180117643Abstract: A washing machine comprises a flocculation container for performing flocculation treatment on washing water. At least one cleaning hairy ball is arranged in the container, a stirring mechanism is arranged in the container, and the stirring mechanism stirs water in the container, so that the cleaning hairy ball moves along with water flow at least in a process of cleaning the container so as to remove flocculates attached to the container. A control method for the washing machine comprises: feeding water to the flocculation container, and starting the stirring mechanism, and allowing the cleaning hairy ball move along with the water flow so as to clean the flocculates attached to the inner of the container. By means of the above device and method, the purpose of removing the flocculates retained in the flocculation container is realized. Besides, the washing machine is simple in structure and has significant effect.Type: ApplicationFiled: April 15, 2016Publication date: May 3, 2018Applicant: QINGDAO HAIER WASHING MACHINE CO., LTD.Inventors: Sheng XU, Zhiqiang ZHAO, Xiuwen PENG, Jinzhu DENG
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Publication number: 20180100261Abstract: Provided are an ozone sterilization washing machine and a method. The ozone sterilization washing machine comprises an outer barrel, an ozone generation device and a heating device, wherein an air inlet communicated with the ozone generation device is arranged at the bottom of the outer barrel, an exhaust hole is arranged at the upper part of the outer barrel and communicated with an exhaust pipeline, and the heating device is arranged in the exhaust pipeline to decompose ozone. According to the ozone sterilization washing machine, clothes are sterilized with ozone, and ozone which is not completely dissolved is thoroughly decomposed under a high temperature at a high decomposition rate; in addition, no catalyst is added, thus saving manpower and material resources.Type: ApplicationFiled: April 15, 2016Publication date: April 12, 2018Applicant: QINGDAO HAIER DRUM WASHING MACHINE CO., LTD.Inventors: Sheng XU, Zhiqiang ZHAO, Yanfen LV
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Patent number: 9923441Abstract: In one aspect of the present invention, a stator of a linear compressor comprises first stator pieces that are circumferentially and sequentially arranged about an axial direction and are radially disposed, second stator pieces that are provided between outer parts of the adjacent first stator pieces, and an outer side, away from a motor axis, of the second stator pieces assembled at an outer circumference of the stator. The stator can reduce the magnetic losses of the stator caused by the gap, and improve the efficiency of the motor. It can also improve the performance, stability, durability and reliability of the linear compressor. It can also reduce the bulk of the linear compressor.Type: GrantFiled: January 22, 2015Date of Patent: March 20, 2018Assignees: HAIER GROUP CORPORATION, HAIER GROUP TECHNIQUE R&D CENTER, QINGDAO HAIER JOINT STOCK CO., LTD.Inventors: Bin Song, Hyeomgkook Lee, Saina Yan, Zhiqiang Zhao, Sheng Xu, Biao Li
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Patent number: 9708336Abstract: The present invention relates to compounds of formula (I) that are metallo-?-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with ?-lactam antibiotics for overcoming resistance.Type: GrantFiled: January 16, 2015Date of Patent: July 18, 2017Assignee: Merck Sharp & Dohme Corp.Inventors: Mihir Mandal, Haifeng Tang, Li Xiao, Jing Su, Guoqing Li, Shu-Wei Yang, Weidong Pan, Haiqun Tang, Reynalda DeJesus, Jacqueline Hicks, Matthew Lombardo, Hong Chu, William Hagmann, Alex Pasternak, Xin Gu, Jinlong Jiang, Shuzhi Dong, Fa-Xiang Ding, Clare London, Dipshikha Biswas, Katherine Young, David N. Hunter, Zhiqiang Zhao, Dexi Yang
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Patent number: 9614886Abstract: A method for processing information applied in a server and the corresponding server is described. The method is applied in a server that stores a file set including a plurality of stream media files. The method includes obtaining a transition parameter when a first terminal apparatus accesses a file set when the first terminal apparatus accesses stream media file in the file set; making statistics of transition probability of each stream media file in the file set transiting to the respective stream media files in the file set according to the transition parameter of at least one first terminal apparatus; determining a target stream media file that the first terminal apparatus accesses most frequently in the stream media files in the file set according to the transition probability; and transmitting the target stream media file to a second terminal apparatus.Type: GrantFiled: March 26, 2014Date of Patent: April 4, 2017Assignee: LENOVO (BEIJING) CO., LTD.Inventors: Qin Zhong, Zhiqiang Zhao, Xiaobo Jia
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Publication number: 20160333021Abstract: The present invention relates to compounds of formula (I) that are metallo-?-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with ?-lactam antibiotics for overcoming resistance.Type: ApplicationFiled: January 16, 2015Publication date: November 17, 2016Applicant: Merck Sharp & Dohme Corp.Inventors: Mihir Mandal, Haifeng Tang, Li Xiao, Jing Su, Guoqing Li, Shu-Wei Yang, Weidong Pan, Haiqun Tang, Reynalda DeJesus, Jacqueline Hicks, Matthew Lombardo, Hong Chu, William Hagmann, Alex Pasternak, Xin Gu, Jinlong Jiang, Shuzhi Dong, Fa-Xiang Ding, Clare London, Dipshikha Biswas, Katherine Young, David N. Hunter, Zhiqiang Zhao, Dexi Yang
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Publication number: 20160303244Abstract: Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.Type: ApplicationFiled: June 24, 2016Publication date: October 20, 2016Applicant: Merck Sharp & Dohme Corp.Inventors: Songnian Lin, Lin Yan, Ahmet Kekec, Yuping Zhu, David N. Hunter, Pei Huo, Danqing Feng, Ravi P. Nargund, Christopher R. Moyes, Zhiqiang Zhao, Brenda Pipik, Dmitri Pissarnitski, Joseph L. Duffy, Erin N. Guidry
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Patent number: 9464103Abstract: Disclosed herein are compounds of Formula (I), wherein each of the substituents is given the definition as set forth in the specification and claims. Also disclosed are pharmaceutical compositions containing the compound of Formula (I) and use of the compound in the treatment of neurodegenerative diseases or conditions such as Alzheimer's disease.Type: GrantFiled: November 22, 2013Date of Patent: October 11, 2016Assignee: MERCK SHARP & DOHME CORP.Inventors: Dmitri Pissarnitski, Zhiqiang Zhao
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Publication number: 20160251407Abstract: Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.Type: ApplicationFiled: October 2, 2014Publication date: September 1, 2016Applicant: Merck Sharp & Dohme Corp.Inventors: Songnian Lin, Lin Yan, Ahmet Kekec, Yuping Zhu, David N. Hunter, Pei Huo, Danqing Feng, Ravi P. Nargund, Christopher R. Moyes, Zhiqiang Zhao, Brenda Pipik, Dmitri Pissarnitski, Joseph L. Duffy, Erin Guidry
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Publication number: 20160126366Abstract: A solar cell unit comprises a cell. The cell includes a cell substrate and a plurality of secondary grid lines disposed on a front surface of the cell substrate. The secondary grid lines comprises an edge secondary grid line adjacent to an edge of the cell substrate and a middle secondary grid line disposed inside of the edge secondary grid line. The secondary grid line comprises a welding portion. At least one welding portion of the edge secondary grid line has a projection area in the cell substrate larger than a welding portion of the middle secondary grid line. The solar cell unit also comprises a plurality of conductive wires spaced apart from each other and welded with the secondary grid lines in the welding portion.Type: ApplicationFiled: June 12, 2015Publication date: May 5, 2016Applicant: BYD COMPANY LIMITEDInventors: Zhiqiang ZHAO, Zhanfeng JIANG, Long HE
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Publication number: 20160128019Abstract: The embodiments disclose a method and mobility management node for paging UEs in a radio communication network. The method may comprise: acquiring history migration information indicating migration of one or more UEs from one or more original physical locations to one or more target physical locations; aggregating the history migration information to obtain statistical information on the history migration from each one of the one or more original physical locations to the one or more target physical locations; and determining a paging area based on the statistical information so as to be used for paging a specific UE.Type: ApplicationFiled: July 9, 2013Publication date: May 5, 2016Inventors: Zhiwei Qu, WeN Xiang, Zhenyu Yu, Wei Zhang, Zhiqiang Zhao, Junyi Zhao, Dongxia Zhu
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Publication number: 20160126372Abstract: A solar cell array comprises a plurality of cells. Each cell has a front surface on which light is incident when the cell is in operation and a back surface opposite to the front surface. The solar cell array also comprises a plurality of conductive wires. Adjacent cells are connected by the plurality of conductive wires. The solar cell array further comprises secondary grid lines disposed on the front surface of the respective cell. The secondary grid lines comprise middle secondary grid lines disposed in the middle of the respective cell and intersecting with the conductive wires, and edge secondary grid lines disposed on the edges of the respective cell and non-intersecting with the conductive wires. The solar cell array also comprises short grid lines disposed on the front surface of the cell. The short grid lines connect the edge secondary grid lines with the conductive wires or with at least one middle secondary grid line.Type: ApplicationFiled: June 12, 2015Publication date: May 5, 2016Applicant: BYD COMPANY LIMITEDInventors: Zhiqiang ZHAO, Meiling TENG, Nan WANG, Zhanfeng JIANG, Long HE
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Publication number: 20160126361Abstract: A solar cell module comprises an upper cover plate, a front adhesive layer, a cell array, a back adhesive layer and a back plate superposed in sequence, the cell array comprising multiple cells, adjacent cells connected by a plurality of conductive wires, at least two conductive wires comprising the metal wire which extends reciprocally between surfaces of adjacent cells, the conductive wires being in contact with the cells, the front adhesive layer in direct contact with the conductive wires and filling between adjacent conductive wires.Type: ApplicationFiled: June 12, 2015Publication date: May 5, 2016Applicant: BYD COMPANY LIMITEDInventors: Zhiqiang ZHAO, Ye TIAN, Handong PENG, Shuping KANG, Zhanfeng JIANG, Long HE
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Publication number: 20160126388Abstract: A solar cell array comprises a plurality of solar cells and a metal wire disposed on adjacent solar cells. The metal wire extends between a surface of a first cell and a surface of a second cell adjacent to the first cell in a serpentine pattern of at least two passes on each cell. The solar cell array also comprises a plurality of secondary grid lines disposed on front surfaces of each cell and welded with the at least two passes.Type: ApplicationFiled: June 12, 2015Publication date: May 5, 2016Applicant: BYD COMPANY LIMITEDInventors: Zhiqiang ZHAO, Zhanfeng JIANG, Long HE
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Publication number: 20160126362Abstract: A solar cell array comprises a plurality of cells, adjacent cells connected by a metal wire. At least one metal wire extends reciprocally between a surface of a first cell and a surface of a second cell adjacent to the first cell to form a plurality of conductive wires. The number of the conductive wires is n, y?y×20%?n?y+y×20%, in which n is an integer and y=4.0533X?1.28/1562*A*B, in which X is a diameter value of the metal wire with mm as a unit, 0.1?X?0.5, A and B representing length and width of the cell with mm as the unit. The cells comprise secondary grid lines disposed on front surfaces thereof. The conductive wires are welded with the secondary grid lines by a welding layer.Type: ApplicationFiled: June 12, 2015Publication date: May 5, 2016Applicant: BYD COMPANY LIMITEDInventors: Zhiqiang ZHAO, Zhanfeng JIANG, Long HE
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Publication number: 20160126373Abstract: A solar cell module, comprising an upper cover plate, a front adhesive layer, a cell, a back adhesive layer and a back plate superposed in sequence, a secondary grid line being disposed on the cell, a conductive wire comprising a metal wire being disposed between the front adhesive layer and a front surface of the cell, a welding layer disposed on a welding position where the conductive wire and the secondary grid line are welded, the welding layer being an alloy containing Sn, Bi and at least one of Cu, In, Ag, Sb, Pb and Zn, in which an amount of Bi is 15 to 60 weight percent.Type: ApplicationFiled: June 12, 2015Publication date: May 5, 2016Applicant: BYD COMPANY LIMITEDInventors: Zhiqiang ZHAO, Weihua TAN, Feiyun LI, Zhanfeng JIANG, Long HE
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Publication number: 20160126390Abstract: A solar cell unit comprises a cell. The cell includes a cell substrate and a secondary grid line disposed on a front surface of the cell substrate. The solar cell unit also comprises a conductive wire intersecting and welded with the secondary grid line. The solar cell unit further comprises a welding portion disposed in a welding position of the secondary grid line with the conductive wire. The welding portion has a projection area larger than that of the secondary grid line with an equal length to the welding portion in a non-welding position.Type: ApplicationFiled: June 12, 2015Publication date: May 5, 2016Applicant: BYD COMPANY LIMITEDInventors: Zhiqiang ZHAO, Zhanfeng JIANG, Long HE
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Publication number: 20160126363Abstract: A solar cell module comprises an upper glass plate, a front adhesive layer, a solar cell array, a back adhesive layer and a back plate superposed in sequence. The solar cell array comprises a plurality of cells, adjacent cells connected by a metal wire. At least one metal wire extends reciprocally between a surface of a first cell and a surface of a second cell adjacent to the first cell to form at least two conductive wires. The cells comprise secondary grid lines disposed on front surfaces thereof. The conductive wires are being welded with the secondary grid lines. At least one of the front adhesive layer and the back adhesive layer has a thickness of larger than or equal to the metal wire in a direction perpendicular to the cell, and smaller than 400 ?m.Type: ApplicationFiled: June 12, 2015Publication date: May 5, 2016Applicant: BYD COMPANY LIMITEDInventors: Xiang SUN, Shencun WANG, Jinxin XUE, Zhiqiang ZHAO, Zhanfeng JIANG