Patents by Inventor Zhiqing Yang
Zhiqing Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11952283Abstract: A silicon-and germanium-based molecular sieve has a framework chemical composition as represented by the formula “SiO2.1/nGeO2”. The silicon/germanium molar ratio is 0.1n30. The molecular sieve has a unique X-ray diffraction pattern. It can be used in adsorptive separation, ion exchange, and catalytic conversion of organic compounds.Type: GrantFiled: July 9, 2020Date of Patent: April 9, 2024Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY SINOPECInventors: Weimin Yang, Wenhua Fu, Zhiqing Yuan, Zhendong Wang, Jiawei Teng, Weichuan Tao, Shengli Zhao
-
Publication number: 20240082977Abstract: A fully-automatic aluminum thermal-spraying corrosion prevention production line based on robots and visual recognition is provided. The production line comprises an automatic feeding system comprising feeding carrying and conveying mechanisms; a laser derusting system comprising a derusting robot, a laser cleaning nozzle and derusting conveying mechanisms; an aluminum thermal-spraying system comprising an aluminum spraying robot and an aluminum thermal-spraying gun; an automatic rolling system comprising a rolling pedestal, a first rolling wheel, a second rolling wheel and a rolling drive mechanism; a laser cutting system; and a discharging and stacking system.Type: ApplicationFiled: April 19, 2022Publication date: March 14, 2024Applicant: GUIZHOU POWER GRID CO., LTDInventors: Bo LI, Zhuoyi LIU, Jun LIU, Jingxin TU, Zhiqing ZHANG, Xi FANG, Shifeng LIU, Xianwu ZENG, Dan YANG, Jinke LU, Wei DU
-
Publication number: 20220220107Abstract: Crystal forms A, B, C, D, E, F, G and H of a compound represented by formula I and a preparation method therefor, as well as medical uses for the various crystal forms and advantages thereof in various aspects.Type: ApplicationFiled: May 21, 2020Publication date: July 14, 2022Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Jianfeng ZHENG, Liang ZHANG, Min ZHAO, Zhenjuan SHI, Xufei LI, Zhiqing YANG
-
Patent number: 11038432Abstract: Provided is a power conversion device including a power converter for performing power conversion between primary-side DC voltage and secondary-side DC voltage, and a control device for controlling the power converter in accordance with a command value, wherein the control device generates a primary-side duty for a primary-side bridge circuit, a secondary-side duty for a secondary-side bridge circuit, and a phase shift amount between the primary-side bridge circuit and the secondary-side bridge circuit, on the basis of a solution of an optimization problem for minimizing a peak absolute value of current flowing through the transformer, under a constraint condition that zero voltage switching operation is achieved, at an operation point based on the command value, thus achieving zero voltage switching operation and suppressing increase in conduction loss, without increase in the number of components.Type: GrantFiled: April 9, 2018Date of Patent: June 15, 2021Assignee: MITSUBISHI ELECTRIC CORPORATIONInventors: Takuya Kajiyama, Takaharu Ishibashi, Zhiqing Yang
-
Publication number: 20200274457Abstract: Provided is a power conversion device including a power converter for performing power conversion between primary-side DC voltage and secondary-side DC voltage, and a control device for controlling the power converter in accordance with a command value, wherein the control device generates a primary-side duty for a primary-side bridge circuit, a secondary-side duty for a secondary-side bridge circuit, and a phase shift amount between the primary-side bridge circuit and the secondary-side bridge circuit, on the basis of a solution of an optimization problem for minimizing a peak absolute value of current flowing through the transformer, under a constraint condition that zero voltage switching operation is achieved, at an operation point based on the command value, thus achieving zero voltage switching operation and suppressing increase in conduction loss, without increase in the number of components.Type: ApplicationFiled: April 9, 2018Publication date: August 27, 2020Applicant: Mitsubishi Electric CorporationInventors: Takuya KAJIYAMA, Takaharu ISHIBASHI, Zhiqing YANG
-
Patent number: 10669302Abstract: Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application thereof in preparing medicine. Crystal forms I and II of the fludarabine phosphate have excellent properties in terms of solubleness, dissolution rate, chemical stability, and processing adaptability.Type: GrantFiled: August 26, 2016Date of Patent: June 2, 2020Assignee: ZHEJIANF HISUN PHARMACEUTICAL CO., LTD.Inventors: Zhiqing Yang, Liang Zhang, Xiangyang Zhang, Zhenjuan Shi, Di Su, Hongying Luo, Dejin Fu
-
Patent number: 10442835Abstract: The present invention relates to technical fields of organic chemistry and pharmaceutical chemistry, specifically to water-soluble rapamycin derivatives modified with glutathione. More specifically, the present invention discloses a compound of formula I and the preparation method thereof, wherein R1 and R2 are as defined in the description. The compound of formula I can be used in inducing immunosuppression and in the treatment of diseases such as transplant rejection and solid tumor, etc.Type: GrantFiled: November 9, 2016Date of Patent: October 15, 2019Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Haibo Wang, Hongfu Kuang, Wei Zhang, Zhengjiang Cai, Tianmin Zhu, Xiaohe Zheng, Zhongwei Wu, Zhiqing Yang
-
Patent number: 10364244Abstract: Provided are crystal forms I, II, III and IV of a pyrroloquinoline quinone sodium salt and a preparation method thereof. Also provided are a pharmaceutical composition, a cosmetic composition, a functional food or a nutritional agent containing the above-mentioned crystal forms. The crystal forms have excellent properties in terms of solubility, crystal stability, hygroscopicity and the like.Type: GrantFiled: September 14, 2016Date of Patent: July 30, 2019Assignee: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Zhiqing Yang, Liang Zhang, Xiangyang Zhang, Zhenjuan Shi, Min Zhao, Hongying Luo
-
Patent number: 10364219Abstract: Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.Type: GrantFiled: December 8, 2017Date of Patent: July 30, 2019Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Hua Bai, Xuyang Zhao, Yuncai Zhang, Xufei Li, Yong Zhang, Dezhou Xu, Li Zhang, Xiaojie Xu, Qifeng Zhu, Xiaoming Wang, Zhiqing Yang, Zehua Zhong, Jian Zhang
-
Publication number: 20190218210Abstract: Provided are crystal forms I, II, III and IV of a pyrroloquinoline quinone sodium salt and a preparation method thereof. Also provided are a pharmaceutical composition, a cosmetic composition, a functional food or a nutritional agent containing the above-mentioned crystal forms. The crystal forms have excellent properties in terms of solubility, crystal stability, hygroscopicity and the like.Type: ApplicationFiled: September 14, 2016Publication date: July 18, 2019Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Zhiqing YANG, Liang ZHANG, Xiangyang ZHANG, Zhenjuan SHI, Min ZHAO, Hongying LUO
-
Publication number: 20190112327Abstract: Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application thereof in preparing medicine. Crystal forms I and II of the fludarabine phosphate have excellent properties in terms of solubleness, dissolution rate, chemical stability, and processing adaptability.Type: ApplicationFiled: August 26, 2016Publication date: April 18, 2019Inventors: Zhiqing YANG, Liang ZHANG, Xiangyang ZHANG, Zhenjuan SHI, Di SU, Hongying LUO, Dejin FU
-
Publication number: 20190055284Abstract: The present invention relates to technical fields of organic chemistry and pharmaceutical chemistry, specifically to water-soluble rapamycin derivatives modified with glutathione. More specifically, the present invention discloses a compound of formula I and the preparation method thereof, wherein R1 and R2 are as defined in the description. The compound of formula I can be used in inducing immunosuppression and in the treatment of diseases such as transplant rejection and solid tumor, etc.Type: ApplicationFiled: November 9, 2016Publication date: February 21, 2019Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Haibo Wang, Hongfu Kuang, Wei Zhang, Zhengjiang Cai, Tianmin Zhu, Xiaohe Zheng, Zhongwei Wu, Zhiqing Yang
-
Patent number: 10196360Abstract: Provided are crystal forms I, II, and III of bedaquiline fumarate, and preparation methods thereof. The crystal forms have high purity, excellent physicochemical properties, and good stability. The preparation methods can effectively improve the quality of products, and are applicable to preparation and mass production of medicines.Type: GrantFiled: October 20, 2015Date of Patent: February 5, 2019Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Jinyi Xu, Liang Zhang, Xiangyang Zhang, Xinzeng Wang, Jian Chai, Hongying Luo, Zhiqing Yang
-
Publication number: 20180346506Abstract: The present invention relates to a method for preparing Sofosbuvir crystal form-6. The method is simple in operation, stable in process condition, good in reproducibility, high in yield rate and high in purity, viscous gel-type products are not formed during the process, the problem of blocking of a discharge port is solved, and the method is suitable for mass industrial production and has high economic value.Type: ApplicationFiled: November 11, 2015Publication date: December 6, 2018Applicant: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.Inventors: Yanghui GUO, Shiguo ZHAO, Yue ZHANG, Liang ZHANG, Zhiqing YANG, Jian CHAI
-
Publication number: 20180273526Abstract: Provided are crystal forms I, II, III and IV of a pyrroloquinoline quinone sodium salt and a preparation method thereof. Also provided are a pharmaceutical composition, a cosmetic composition, a functional food or a nutritional agent containing the above-mentioned crystal forms. The crystal forms have excellent properties in terms of solubility, crystal stability, hygroscopicity and the like.Type: ApplicationFiled: September 14, 2016Publication date: September 27, 2018Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Zhiqing YANG, Liang ZHANG, Xiangyang ZHANG, Zhenjuan SHI, Min ZHAO, Hongying LUO
-
Patent number: 10081599Abstract: The present invention relates to a preparation method of 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-formamide capable of enabling 4-chlorine-N-methylpyridine-2-formamide to react with 4-amino-3-fluorophenol in the presence of an inorganic base. The present invention employs the inorganic base to replace potassium t-butoxide in the prior art, thus effectively solving the problem of a potential safety hazard of the potassium t-butoxide in industrial production. In addition, after the reaction is completed, the present invention employs a crystallization method for separation to obtain a reaction product; thus compared with the methods of extraction, concentration and column isolation and purification employed in the prior art, the present invention has a simpler operation and a lower cost, results in less environment pollution and a higher yield, and is very suitable for industrial production.Type: GrantFiled: November 9, 2015Date of Patent: September 25, 2018Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Guan Wang, Xufeng Yu, Guo Wei, Jian Chai, Zhiqing Yang
-
Publication number: 20180265473Abstract: Provided are crystal forms I, II, and III of bedaquiline fumarate, and preparation methods thereof. The crystal forms have high purity, excellent physicochemical properties, and good stability. The preparation methods can effectively improve the quality of products, and are applicable to preparation and mass production of medicines.Type: ApplicationFiled: October 20, 2015Publication date: September 20, 2018Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Jinyi Xu, Liang Zhang, Xiangyang Zhang, Xinzeng Wang, Jian Chai, Hongying Luo, Zhiqing Yang
-
Publication number: 20180244711Abstract: Provided are a new crystal form of fludarabine phosphate, a preparation method therefor, a pharmaceutical composition containing same, and an application thereof in preparing medicine. Crystal forms I and II of the fludarabine phosphate have excellent properties in terms of solubleness, dissolution rate, chemical stability, and processing adaptability.Type: ApplicationFiled: August 26, 2016Publication date: August 30, 2018Inventors: Zhiqing YANG, Liang ZHANG, Xiangyang ZHANG, Zhenjuan SHI, Di SU, Hongying LUO, Dejin FU
-
Publication number: 20180099930Abstract: Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.Type: ApplicationFiled: December 8, 2017Publication date: April 12, 2018Applicant: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Hua Bai, Xuyang Zhao, Yuncai Zhang, Xufei Li, Yong Zhang, Dezhou Xu, Li Zhang, Xiaojie Xu, Qifeng Zhu, Xiaoming Wang, Zhiqing Yang, Zehua Zhong, Jian Zhang
-
Patent number: 9926268Abstract: Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production.Type: GrantFiled: June 5, 2015Date of Patent: March 27, 2018Assignee: Zhejiang Hisun Pharmaceutical Co., Ltd.Inventors: Hua Bai, Xuyang Zhao, Yuncai Zhang, Xufei Li, Yong Zhang, Dezhou Xu, Li Zhang, Xiaojie Xu, Qifeng Zhu, Xiaoming Wang, Zhiqing Yang, Zehua Zhong, Jian Zhang