Patents by Inventor Zhiren Xia

Zhiren Xia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo-[1,2-a]pyrazin-2(1H)-ylcarbonyl]-benzenesulfonamide, and pharmaceutically acceptable salts thereof
    Patent number: 8741899
    Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: June 3, 2014
    Assignee: AbbVie Inc.
    Inventors: Qingwei Zhang, Andrew O. Stewart, Zhiren Xia
  • Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers
    Patent number: 8669255
    Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: March 11, 2014
    Assignee: AbbVie Inc.
    Inventors: Tao Li, Sachin V. Patel, Richard J. Perner, John T. Randolph, Michael R. Schrimpf, Kevin R. Woller, Zhiren Xia, Qingwei Zhang
  • Substituted octahydropyrrolo[1,2-]pyrazine sulfonamides as calcium channel blockers
    Patent number: 8648074
    Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z?, Z?, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: February 11, 2014
    Assignee: AbbVie Inc.
    Inventors: Tao Li, Sachin V. Patel, Richard J. Perner, John T. Randolph, Michael R. Schrimpf, Kevin R. Woller, Zhiren Xia, Qingwei Zhang
  • Substituted piperidinylcarbonylbenzenesulfonamides as calcium channel blockers
    Patent number: 8404719
    Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: March 26, 2013
    Assignee: AbbVie Inc.
    Inventors: Qingwei Zhang, Andrew O. Stewart, Zhiren Xia
  • NOVEL BENZENESULFONAMIDES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20120083499
    Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: December 12, 2011
    Publication date: April 5, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Qingwei Zhang, Andrew O. Stewart, Zhiren Xia
  • Substituted pyrrolo [1,2-a] pyrazines as calcium channel blockers
    Patent number: 8101614
    Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: January 24, 2012
    Assignee: Abbott Laboratories
    Inventors: Qingwei Zhang, Andrew O. Stewart, Zhiren Xia
  • Cyclobut-3-ene-1,2,-dione inhibitors of polo-like kinases
    Patent number: 7956185
    Abstract: Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: June 7, 2011
    Assignee: Abbott Laboratories
    Inventors: Robert B. Diebold, Stevan W. Djuric, Vincent L. Giranda, Laura A. Hexamer, Nan-Horng Lin, Julie M. Miyashiro, Thomas D. Penning, Magdalena Przytulinska, Thomas J. Sowin, Gerard M. Sullivan, Zhi-Fu Tao, Yunsong Tong, Anil Vasudevan, Le Wang, Keith W. Woods, Zhiren Xia, Henry Q. Zhang
  • NOVEL BENZENESULFONAMIDES AS CALCIUM CHANNEL BLOCKERS
    Publication number: 20100197693
    Abstract: The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: January 14, 2010
    Publication date: August 5, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Qingwei Zhang, Andrew O. Stewart, Zhiren Xia
  • Acetamides and benzamides that are useful in treating sexual dysfunction
    Patent number: 7528134
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: May 5, 2009
    Assignee: Abbott Laboratories Inc.
    Inventors: Pramila A. Bhatia, Jerome F. Daanen, Ahmed A. Hakeem, Teodozyj Kolasa, Mark A. Matulenko, Kathleen H. Mortell, Meena V. Patel, Andrew O. Stewart, Xueqing Wang, Zhiren Xia, Henry Q. Zhang
  • Tricyclic pyrazole kinase inhibitors
    Patent number: 7468371
    Abstract: Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: December 23, 2008
    Assignee: Abbott Laboratories Inc.
    Inventors: Lee D. Arnold, Jürgen Dinges, Richard W. Dixon, Stevan W. Djuric, Anna M. Ericsson, Kimba Fischer, Alan F. Gasiecki, Vijaya J. Gracias, James H. Holms, Makoto Takeshita, Michael R. Michaelides, Melanie A. Muckey, Paul Rafferty, Douglas H. Steinman, Carol K. Wada, Zhiren Xia, Irini Akritopoulou-Zanze, Henry Q. Zhang
  • INHIBITORS OF POLO-LIKE KINASES
    Publication number: 20080015192
    Abstract: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
    Type: Application
    Filed: May 24, 2007
    Publication date: January 17, 2008
    Inventors: Robert Diebold, Stevan Djuric, Vincent Giranda, Laura Hexamer, Nan-Horng Lin, Julie Miyashiro, Thomas Penning, Magdalena Przytulinska, Thomas Sowin, Gerard Sullivan, Zhi-Fu Tao, Yunsong Tong, Anil Vasudevan, Le Wang, Keith Woods, Zhiren Xia, Henry Zhang
  • Tricyclic pyrazole kinase inhibitors
    Publication number: 20060014816
    Abstract: Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
    Type: Application
    Filed: March 24, 2005
    Publication date: January 19, 2006
    Inventors: Lee Arnold, Jurgen Dinges, Richard Dixon, Stevan Djuric, Anna Ericsson, Kimba Fischer, Alan Gasiecki, Vijaya Gracias, James Holms, Makoto Takeshita, Michael Michaelides, Melanie Muckey, Paul Rafferty, Douglas Steinman, Carol Wada, Zhiren Xia, Irini Akritopoulou-Zanze, Henry Zhang
  • Acetamides and benzamides that are useful in treating sexual dysfunction
    Publication number: 20060009461
    Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.
    Type: Application
    Filed: September 9, 2005
    Publication date: January 12, 2006
    Inventors: Pramila Bhatia, Jerome Daanen, Ahmed Hakeem, Teodozyj Kolasa, Mark Matulenko, Kathleen Mortell, Meena Patel, Andrew Stewart, Xueqing Wang, Zhiren Xia, Henry Zhang
  • Novel amides that activate soluble guanylate cyclase
    Publication number: 20040121994
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: December 20, 2002
    Publication date: June 24, 2004
    Inventors: Steven N. Anderson, Pramila Bhatia, Teodozyj Kolasa, Masaki Nakane, Meena V. Patel, Jeffrey J. Rohde, Zhiren Xia, Henry Q. Zhang
  • Acetamides and benzamides that are useful in treating sexual dysfunction
    Publication number: 20040029887
    Abstract: The present invention relates to the use of compounds of formula (I) 1
    Type: Application
    Filed: April 29, 2003
    Publication date: February 12, 2004
    Inventors: Pramila A. Bhatia, Jerome F. Daanen, Ahmed A. Hakeem, Teodozyj Kolasa, Mark A. Matulenko, Kathleen H. Mortell, Meena V. Patel, Andrew O. Stewart, Xueqing Wang, Zhiren Xia, Henry Q. Zhang
  • Acetamides and benzamides that are useful in treating sexual dysfunction
    Publication number: 20030229094
    Abstract: The present invention relates to the use of compounds of formula (I) 1
    Type: Application
    Filed: May 23, 2003
    Publication date: December 11, 2003
    Inventors: Pramila A. Bhatia, Jerome F. Daanen, Ahmed A. Hakeem, Teodozyj Kolasa, Mark A. Matulenko, Kathleen H. Mortell, Meena V. Patel, Andrew O. Stewart, Xueqing Wang, Zhiren Xia, Henry Q. Zhang