Patents by Inventor Zhisong Chen

Zhisong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LISTERIA-BASED IMMUNOGENIC COMPOSITIONS FOR ELICITING ANTI-TUMOR RESPONSES
    Publication number: 20180064765
    Abstract: The present invention is directed to compositions comprising an immune checkpoint inhibitor or a T cell stimulator or a combination thereof, and a live attenuated recombinant Listeria strain comprising a fusion polypeptide comprising a truncated Listeriolysin O protein, a truncated ActA protein, or a PEST amino acid sequence fused to a tumor-associated antigen. The invention is further directed to methods of treating, protecting against, and inducing an immune response against a tumor or a cancer, comprising the step of administering the same.
    Type: Application
    Filed: July 17, 2015
    Publication date: March 8, 2018
    Inventors: Robert PETIT, Anu Wallecha, Samir Khleif, Zhisong Chen, Jay A. Berzofsky
  • METHODS AND COMPOSITIONS FOR INCREASING A T-EFFECTOR CELL TO REGULATORY T CELL RATIO
    Publication number: 20170080064
    Abstract: The present invention is directed to methods for increasing T-cell effector cell to regulatory T cell ratio. The invention is further directed to methods of treating, protecting against, and inducing an immune response against a tumor, comprising the step of administering to a subject a recombinant Listeria strain, comprising a fusion peptide that comprises an LLO fragment and tumor-associated antigen.
    Type: Application
    Filed: March 5, 2015
    Publication date: March 23, 2017
    Inventors: Robert Petit, Anu Wallecha, Zhisong Chen, Jay A Berzofsky, Samir Khleif