Abstract: Disclosed is a set of adhesive adapters containing sample barcodes for specifically tagging different samples. Further disclosed is a method for simultaneously detecting CpG methylation in a high number of samples, which is multi-sample reduced-representation bisulfite sequencing (msRRBS); and an alternative method thereof, which is multi-sample reduced-representation APOBEC sequencing (msRRAS). The adapters are used to specifically tag the plurality of samples, including all DNA fragments of the plurality of samples; then the plurality of samples are pooled to allow a single-tube reaction of the plurality of samples; and then the subsequent conversion, sequencing library construction and sequencing, distribution and decoding of readings of each sample, and downstream analysis are conducted. The library construction technology of the present application has advantages such as high efficiency, low cost, and stable and convenient operations.

Abstract: Implementations of this specification provide graph data processing systems and methods. An example graph data processing system includes a data storage system and a graph computing engine. The data storage system is configured to store a plurality of pieces of graph data corresponding to a plurality of versions, where the plurality of pieces of graph data are generated based on a plurality of groups of service data generated by a target service system in a plurality of consecutive time intervals. The graph computing engine is configured to receive a graph feature computing request. The graph computing engine is further configured to search the plurality of pieces of graph data stored in the data storage system for a plurality of pieces of target graph data corresponding to the plurality of target versions, and compute graph features of the plurality of pieces of target graph data.

Abstract: An antibody specifically binding to CTLA-4 or an antigen-binding fragment thereof, and a composition comprising same. Also provided are a nucleic acid molecule encoding the antibody or an antigen-binding fragment thereof, a vector and a host cell for expressing the antibody or an antigen-binding fragment thereof, and therapcutic and diagnostic methods and the use of the antibody or an antigen-binding fragment thereof.

Abstract: The present disclosure relates to a method for measuring full-field strain of an ultra-high temperature (UHT) object based on a digital image correlation method. The temperature range is from normal temperature to 3500 degrees Celsius. The method includes the steps of selecting a proper high-temperature-resistant speckle material, tantalum carbide powder, according to the characteristics of the object to be measured. First, polishing a to-be-measured surface of a tungsten test piece to remove an oxide layer, then mixing the tantalum carbide (TaC) powder and absolute ethanol to form a paste according to a mass ratio of 1:2. Making randomly distributed speckles from the mixture on the to-be-measured surface of the test piece which has been processed. In order to improve firmness and stability of the newly made speckles, performing curing treatment to the speckles.

Abstract: The present disclosure relates to a method for measuring full-field strain of an ultra-high temperature (UHT) object based on a digital image correlation method. The temperature range is from normal temperature to 3500 degrees Celsius. The method includes the steps of selecting a proper high-temperature-resistant speckle material, tantalum carbide powder, according to the characteristics of the object to be measured. First, polishing a to-be-measured surface of a tungsten test piece to remove an oxide layer, then mixing the tantalum carbide (TaC) powder and absolute ethanol to form a paste according to a mass ratio of 1:2. Making randomly distributed speckles from the mixture on the to-be-measured surface of the test piece which has been processed. In order to improve firmness and stability of the newly made speckles, performing curing treatment to the speckles.

Abstract: The present application relates to an optical signal receiving apparatus, including a housing for accommodating a body inside the housing, where the body is provided with an optical receiver for receiving an external optical signal, and an optical-to-electrical conversion device is arranged at a central position of the optical receiver. The optical signal receiving apparatus is further provided with a lamp cup for reflecting the external optical signal to the optical-to-electrical conversion device, a light ring for indicating a light incident region, a pry-proof circuit arranged on the body, a power control circuit, and a keying circuit. The optical signal receiving apparatus of the present application can improve user experience.

Abstract: The present application relates to an optical communication transmitting apparatus and receiving apparatus. The optical communication transmitting apparatus includes: an encoder, configured to encode and shunt an input signal, to generate multiple synchronous encoded signals; a driver, configured to amplify the multiple encoded signals, to generate multiple drive signals; and multiple light sources, configured to generate multiple synchronous optical signals when driven by the multiple drive signals. The optical communication transmitting apparatus and receiving apparatus provided in the present application make full use of advantages of visible light communication, achieving a rapid communication speed and high security.

Abstract: The present application relates to an optical signal receiving apparatus, including a housing for accommodating a body inside the housing, where the body is provided with an optical receiver for receiving an external optical signal, and an optical-to-electrical conversion device is arranged at a central position of the optical receiver. The optical signal receiving apparatus is further provided with a lamp cup for reflecting the external optical signal to the optical-to-electrical conversion device, a light ring for indicating a light incident region, a pry-proof circuit arranged on the body, a power control circuit, and a keying circuit. The optical signal receiving apparatus of the present application can improve user experience.

Abstract: The present application relates to an optical communication transmitting apparatus and receiving apparatus. The optical communication transmitting apparatus includes: an encoder, configured to encode and shunt an input signal, to generate multiple synchronous encoded signals; a driver, configured to amplify the multiple encoded signals, to generate multiple drive signals; and multiple light sources, configured to generate multiple synchronous optical signals when driven by the multiple drive signals. The optical communication transmitting apparatus and receiving apparatus provided in the present application make full use of advantages of visible light communication, achieving a rapid communication speed and high security.

Abstract: A group of mutant PTP?genes in malignant tumor are provided, which are ?PTP?245, ?PTP?652 and ?PTP?445 respectively. The mutation includes insertion of 95 new nucleotides after nucleotide at position 711, deletion of nucleotides at position 1015-1437, and deletion of nucleotides at position 1015-1437 accompanied by insertion of 340 nucleotides after coding exon at position 1681 and fusion of 26 new amino acids at C-terminal. The group of mutant PTP?genes in different types of malignant tumor disclosed in the present application have not been reported all over the world so far. The detection method of using PTP?mutant genes is useful in exactly diagnosing malignant tumor, developing new anti-tumor drugs, and targeted treatment at molecular pathologic level.

Abstract: A group of mutant PTP ? genes in malignant tumor are provided, which are ?PTP?245, ?PTP?652 and ?PTP?445 respectively. The mutation includes insertion of 95 new nucleotides after nucleotide at position 711, deletion of nucleotides at position 1015-1437, and deletion of nucleotides at position 1015-1437 accompanied by insertion of 340 nucleotides after coding exon at position 1681 and fusion of 26 new amino acids at C-terminal. The group of mutant PTP ? genes in different types of malignant tumor disclosed in the present application have not been reported all over the world so far. The detection method of using PTP ? mutant genes is useful in exactly diagnosing malignant tumor, developing new anti-tumor drugs, and targeted treatment at molecular pathologic level.