Abstract: Disclosed herein are exemplary embodiments of methods, apparatus, and systems for performing content-adaptive deblocking to improve the visual quality of video images compressed using block-based motion-predictive video coding. For instance, in certain embodiments of the disclosed technology, edge information is obtained using global orientation energy edge detection (“OEED”) techniques on an initially deblocked image. OEED detection can provide a robust partition of local directional features (“LDFs”). For a local directional feature detected in the partition, a directional deblocking filter having an orientation corresponding to the orientation of the LDF can be used. The selected filter can have a filter orientation and activation thresholds that better preserve image details while reducing blocking artifacts. In certain embodiments, for a consecutive non-LDF region, extra smoothing can be imposed to suppress the visually severe blocking artifacts.

Abstract: Provided herein are Bridged Compounds having the following structures: wherein R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b, R3c, R3d, R4, R5, R6, R7, R8, m1, m2, m3, n2, n3, n4, q, X1, X2, Y1, Y2, L1 and ring A are as defined herein, compositions comprising an effective amount of a Bridged Compound, and methods for treating or preventing various diseases, e.g., pancreatic cancer, or a condition treatable or preventable by inhibition of the function of KRAS protein. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of the function of KRAS protein with G12D mutation. In another aspect, a Bridged Compound is useful for treating or preventing a condition treatable or preventable by inhibition of a RAS/MAPK pathway.

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Abstract: Disclosed are a method and a system for bug localization based on a code knowledge graph, including the steps of: extracting source codes from a Git version control system, parsing in the source codes to generate an abstract syntax tree (AST), constructing a code knowledge graph, preprocessing the summary and description of a bug report crawled from a Bugzilla bug tracking system, and performing the named entity recognition to identify bug-related entity sequence, converting the code knowledge graph and the bug-related entity sequence into vector representation through an embedding algorithm, calculating cosine similarities of vector representations between the code knowledge graph and the bug entity sequence, ranking the similarities from high to low to generate a list of suspicious methods, filtering redundant information in the source codes, identifying bug-related entity elements in the bug report, and reserving the bug-related information.

Abstract: A multi-orientation fingertip planar tactile feedback device includes a planar tactile feedback actuator. The planar tactile feedback actuator includes a holder and a feedback mechanism, a holding hole and an accommodating cavity are provided in the holder, one end of the holding hole penetrates through the holder, the other end is communicated with the accommodating cavity, the feedback mechanism includes a plurality of feedback parts that are arranged on cavity walls of the accommodating cavity respectively, and each feedback part includes a base, an air bag block and a baffle which are sequentially connected. A structure is simple; a finger touch force can be adjusted; five pairs of electrified coils are arranged, and force feedback vector synthesis can be performed therebetween; a direction of the force feedback generated by the electrified coil can be consistent with a direction of tactile feedback of the distal finger segment by the baffle.

Abstract: A water-based electronic cigarette liquid is disclosed. The water-based electronic cigarette liquid includes the following ingredients in parts by mass: 5-60 parts of water, 5-50 parts of smoke ingredient which is solid at normal temperature and is soluble in water, and 0-30 parts of glycerol. The electronic cigarette liquid in this invention has environmental protection, high safety, comfortable smoking taste, high smoke producing effect, and low viscosity.

Abstract: A low-harm cigarette subjected to smoke enhancement, comprising cigarette paper, a filter tip, and an aerosol generating substrate. The aerosol generating substrate comprises a tobacco sheet subjected to smoke enhancement and/or tobacco shreds subjected to smoke enhancement.

Abstract: Embodiments of the present invention relate to use of a GP73 inhibitor in preparation of a drug for treating diabetes. In the embodiments of the present invention, the inventor finds that GP73 plays a key role in blood glucose regulation, and in particular, finds that soluble GP73 can specifically bind to glucagon to form a complex, enhances the blood glucose-rising function and gluconeogenesis function of glucagon and prolongs the half-life of glucagon; and finds soluble GP73 can activate the glucose production in liver and/or kidney and a gluconeogenesis signaling pathway in a glucagon-independent manner. Based on the blood glucose regulation effect of the GP73 described above, the inventor also proves through animal experiments: the GP73 inhibitor can reduce the blood glucose level and glycated hemoglobin level of diabetic mice and have a protective effect on islet ? cells, and thereby having the effect of treating diabetes.

Abstract: A system and method for efficiently storing and accessing large volumes of metadata persistent on Non-Volatile Memory (NVM) storage systems is provided. The system applies log-structured, Copy-on-Write (CoW) B+ tree methods, and supports a core-affine data and resource partitioning approaches on the system's architecture and platform with a high-degree of parallelism within the CPU, NVMe storage, and networking devices. The subject system and method efficiently indexes both in-core (DRAM resident) and out-of-core (NVM resident) metadata, supports a variety of data access patterns, supports CoW features and provides verifiable data safety and integrity capabilities. The present system minimizes latencies over all aspects of the metadata management and access path by leveraging core-affine resource partitioning with runtime environment providing lightweight user-level threads with low-latency context switching that execute within the exclusive context of a dedicated CPU core, and partitioned resources.

Abstract: A cooling cigarette filter and a cigarette are disclosed. The cooling cigarette filter comprises a cooling section (2). The cooling section (2) comprises a cooling stick (201) formed from paper (5). The cooling stick (201) has one or more holes (202) communicating two ends of the cooling stick. And the surface of the paper (5) is coated with a cooling material. The cooling cigarette filter has the advantages of ensuring the amount of smoke and lowering the temperature of the smoke entering the mouth. Through the combination design of the structure of the cooling stick and the type and amount of the cooling material, the smoke can flow out of a smoke generation section rapidly and smoothly And the temperature of the high-temperature smoke before entering the mouth can be significantly lowered, thereby improving the comfort and satisfaction of smoking.

Abstract: A system and method for efficiently storing and accessing large volumes of metadata persistent on Non-Volatile Memory (NVM) storage systems is provided. The system applies log-structured, Copy-on-Write (CoW) B+ tree methods, and supports a core-affine data and resource partitioning approaches on the system's architecture and platform with a high-degree of parallelism within the CPU, NVMe storage, and networking devices. The subject system and method efficiently indexes both in-core (DRAM resident) and out-of-core (NVM resident) metadata, supports a variety of data access patterns, supports CoW features and provides verifiable data safety and integrity capabilities. The present system minimizes latencies over all aspects of the metadata management and access path by leveraging core-affine resource partitioning with runtime environment providing lightweight user-level threads with low-latency context switching that execute within the exclusive context of a dedicated CPU core, and partitioned resources.

Abstract: The present invention provides human anti-human epidermal growth factor receptor (EGFR) antibodies and their encoding genes and applications thereof. By gene engineering means and phage surface display technology, the present invention screens anti-human EGFR gene engineering single chain antibody from fully synthetic single chain human antibody library, and obtains the antibody variable gene sequence thereof, and based thereon, constructs intact human monoclonal antibody, to further obtain high-purity antibody protein. The binding affinity of the antibody of the present invention with human EGFR is no more than 1 nM, and the mutants affinity thereof is no more than 10 nM; and the identification of the immunity activity and bioactivity of antibodies protein IgG is completed, confirming that the antibody of the present invention has good bioactivity of inhibiting the tumor growth of EGFR expressing cell A431 tumor-bearing model mouse.

Abstract: Method and system for data migration between data generating entities and data storage devices protected by de-clustered RAID algorithm are enhanced by dynamically controlling the I/O activity towards the data storage devices (NVM devices) based on their remaining lifespan (health) with the goal to prevent multiple devices selected for writing a parity stripe information from simultaneous failures. This feature is rendered by polling the remaining health of NVM devices in the RAID pool, computing a weighted lifespan for each NVM device, comparing the latter to an average of all NVM devices in the pool, and adjusting the I/O activity towards the NVM device of interest accordingly. If the weighted lifespan exceeds the average lifespan in the pool, the allowed I/O activity is increased, and if the weighted lifespan is below the average for the pool, then the device in question is sent less “writes”.

Abstract: The present invention provides human anti-human epidermal growth factor receptor (EGFR) antibodies and their encoding genes and applications thereof. By gene engineering means and phage surface display technology, the present invention screens anti-human EGFR gene engineering single chain antibody from fully synthetic single chain human antibody library, and obtains the antibody variable gene sequence thereof, and based thereon, constructs intact human monoclonal antibody, to further obtain high-purity antibody protein. The binding affinity of the antibody of the present invention with human EGFR is no more than 1 nM, and the mutants affinity thereof is no more than 10 nM; and the identification of the immunity activity and bioactivity of antibodies protein IgG is completed, confirming that the antibody of the present invention has good bioactivity of inhibiting the tumor growth of EGFR expressing cell A431 tumor-bearing model mouse.