Abstract: The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.

Abstract: A power module is disclosed and includes an upper surface for receiving multiple input signals, a lower surface for outputting multiple output signals, a top layer circuit board, a bottom layer circuit board and a middle layer. The top layer circuit board includes a first surface and a second surface disposed opposite to each other, and multiple electronic devices. The first surface forms the upper surface, and multiple first signal connection parts are disposed on the first surface for receiving the multiple input signals. The bottom layer circuit board includes a third surface and a fourth surface disposed oppositely. The fourth surface forms the lower surface, and multiple second signal connection parts are disposed on the fourth surface for outputting the multiple output signals. The middle layer is disposed between the top layer circuit board and the bottom layer circuit board.

Abstract: The present disclosure relates to a layered bimetallic hydroxide-based hydrogel bipolar membrane and a method for preparing the same. The method includes: blade-coating a quaternized polyethersulfone solution on a substrate, and carrying out drying to obtain an anion exchange layer; immersing the layer sequentially and cyclically in a sodium alginate solution and a first metal ion mixed solution to obtain a hydrogel anion exchange membrane; immersing the hydrogel membrane sequentially in a second metal ion mixed solution and an alkaline solution; and blade-coating a sulfonated polyethersulfone solution on the obtained membrane, and carrying out drying to obtain the layered bimetallic hydroxide-based hydrogel bipolar membrane. The anion and cation exchange membrane layers on two sides of the bipolar membrane prepared in the present disclosure are closely bound by way of hydrogel cross-linking.

Abstract: The present disclosure discloses a cable organizing mechanism, including: a first plate body and a second plate body. When the second plate body is mutually clamped with the first plate body, an opening allowing a joint of a cable to pass through is closed to form at least one a pass-through hole configured to allow the cable to pass through. The present disclosure further includes a cable arranging mechanism, including an extending plate connected with at least one of the first plate body or the second plate body and an auxiliary plate mutually clamped with the extending plate. The present disclosure can solve the problem that after cables between a cabinet and a switch are organized in order, a cable organizing effect is unfavorable, and the cables cannot be completely spaced apart, and quality of project construction is affected.

Abstract: The present invention discloses an SMA wire-driven reusable release mechanism having a self-resetting function. The present invention adopts a structure of two-stage load reduction and one-stage release. First-stage load reduction: a compression rod and a hoop petal, as well as an inclined block and a shell or a sliding block, all cooperate with each other by means of inclined surfaces, which can transfer most of tension load of the compression rod to the shell, leaving only a small part of the load transmitted to a thrust bearing. Second-state load reduction: balls in the thrust bearing are coated with a molybdenum disulfide lubricating coating, which can effectively reduce friction so as to reduce a torque transmitted to a driving shaft. First-stage release: the driving shaft drives a thrust bearing to rotate by a certain angle, causing an upper ring of the thrust bearing to descend to release a certain axial clearance.

Abstract: Disclosed herein is 3-[(1H-pyrazol-4-yl)oxy]pyrazin-2-amine compounds of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of modulating, e.g.

Abstract: This disclosure provides compounds containing 4-(aminomethyl)-6-(1-methyl-1H-pyrazol-4-yl) isoquinolin-1 (2H)-onestructure, the use thereof for selectively inhibiting the activity of PRMT5 in cooperative with MTA in tumors bearing MTAPDEL mutation, and pharmaceutical compositions comprising the compounds as treatment of various diseases including cancer.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase ligand moieties, methods of preparation, and uses thereof.

Abstract: The present invention belongs to the technical field of membrane-based water treatment and relates to a novel guanidine-based composite nanofiltration (NF) flat-sheet membrane, and a preparation method and application thereof. The present invention provides a method for preparing a guanidine-based composite NF flat-sheet membrane, where a dense separation layer is formed on the surface of a polyethersulfone ultrafiltration membrane through polymerization reaction between the amino group of 1,3-diaminoguanidine and the acyl chloride group of trimesoyl chloride. Under suitable reaction conditions, the guanidine-based composite NF membrane obtained according to the present invention enables effective separation of multivalent ions over a wide pH range, with a rejection rate of over 96% for 1000 ppm of MgSO4 solution, and can operate continuously and stably in a mixed ions solution with a wide pH.

Abstract: The present invention relates to a crystalline form of(S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetr a-hydropyrazolo [1,5-a]pyrimi dine-3-carboxamide for inhibiting Btk, methods of preparation thereof and pharmaceutical compositions, and use of the crystalline form above in the treatment of a disease, or in the manufacturing of a medicament for the treatment of a disease.

Abstract: A gap caulking device and a caulking method are provided, wherein the gap caulking device includes long plates, short plates, a dial plate, a three-way joint, a tensioner and a limit rod, and a closed quadrilateral structure with an adjustable angle is formed by two long plates hinged to each other and two short plates hinged to each other, a dial plate and a pointer are respectively provided on the two short plates, damping rods hinged on the two short plates to each other and a three-way joint matched with the two long plates are passed through by a limit rod to achieve connection limiting, and a shape memory alloy wire is connected to the three-way joint by a tensioner and is parallel to the limit rod. The problem is overcome that the original traditional wedge-shaped material that gaps rely on has a single filling function.

Abstract: Disclosed herein is a compound of Formula (I) for inhibiting both Bcl-2 wild type and mutated Bcl-2, in particular, Bcl-2 G101V and D103Y, and a method of using the compound disclosed herein for treating dysregulated apoptotic diseases.

Abstract: Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating BTK inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

Abstract: This disclosure provides 5-amino-6,8-dihydro-1H-furo[3,4-d]pyrrolo[3,2-b]pyridine-2-carboxamide derivatives, the use thereof for selectively inhibiting the activity of PRMT5 in cooperation with MTA in tumors bearing MTAPDEL mutation, and pharmaceutical compositions comprising the compounds, e.g., for treatment of various diseases including cancer.

Abstract: A large-dip-angle self-leveling device is provided. The device comprises a mounting base platform arranged on a mounting stand column and a support cylinder connected with the mounting base platform. A leveling plate is arranged at the top of the mounting base platform, and a leveling platform is arranged on the leveling plate. A spirit bubble indicator and a control circuit board are arranged on the leveling platform. A connecting rod of balance weight is arranged in the support cylinder, one end of the connecting rod of balance weight is connected with the leveling platform, and the other end is connected with a balance weight. A four-core cable penetrates through the connecting rod of balance weight and the balance weight. Observation windows are symmetrically arranged at the lower part of the support cylinder. A melting pool is arranged at the bottom in the support cylinder.

Abstract: A method for recycling a scrapped polyvinylidene fluoride (PVDF) membrane through chemical cleaning-structural transformation-hydrophilicity is disclosed, which can extend the service life of scrapped PVDF membrane materials (namely, membrane at the end of service life). The method includes the following steps: cleaning a scrapped membrane with sodium hypochlorite and citric acid; treating the membrane with a structural transformation agent, where, irreversible contaminants are washed away while the PVDF membrane is subjected to pore expansion and hydrophilization; and with self-polymerization of dopamine on a membrane surface, further improving the hydrophilicity of the membrane surface, enhancing the anti-contamination performance, and repairing damaged points on the surface of the scrapped PVDF membrane produced during long-term operation.

Abstract: Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.