Patents by Inventor Zhixiang He

Zhixiang He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOMODULATORY COMPOUNDS
    Publication number: 20210284624
    Abstract: Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.
    Type: Application
    Filed: June 27, 2019
    Publication date: September 16, 2021
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael Gray, Tinghu Zhang, Eric Fischer, Alyssa Verano, Zhixiang He, Guangyan Du, Katherine Donovan, Radoslaw Nowak, Jing Ting Christine Yuan, Hu Liu
  • NEW CRBN MODULATORS
    Publication number: 20210277018
    Abstract: Disclosed are degraders, pharmaceutical compositions containing them, and methods of making and using the degraders to treat diseases and disorders characterized by dysregulated or dysfunctional protein activity that can be targeted by cereblon.
    Type: Application
    Filed: June 27, 2019
    Publication date: September 9, 2021
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael Gray, Tinghu Zhang, Eric Fischer, Alyssa Verano, Zhixiang He, Guangyan Du, Katherine Donovan, Radoslaw Nowak, Jing Ting Christine Yuan
  • HETEROBIFUNCTIONAL COMPOUNDS WITH IMPROVED SPECIFICITY
    Publication number: 20210130368
    Abstract: Disclosed are heterobifunctional compounds that effectuate selective degradation of a target protein, and which include a targeting ligand that binds a target protein and at least one other protein, a ligand that binds an E3 ubiquitin ligase or a component of E3 ubiquitin ligase, and a specificity modulating linker that links the first ligand and the second ligand. Pharmaceutical compositions containing the compounds, and methods of using and making the compounds are also disclosed.
    Type: Application
    Filed: October 19, 2018
    Publication date: May 6, 2021
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Radoslaw P. NOWAK, Eric S. FISCHER, Nathanael S. GRAY, Tinghu ZHANG, Zhixiang HE, Brian GROENDYKE
  • Pyrimidine seven-membered-ring compounds, preparation method therefor, pharmaceutical composition thereof, and uses thereof
    Patent number: 10975092
    Abstract: The present invention relates to compounds (I) capable of inhibiting the Mst1/2 protein kinase activity, a preparation method therefor, a pharmaceutical composition comprising the compounds, and uses of the compounds and the pharmaceutical composition comprising the compounds in the preparation of drugs for prompting repair and regeneration of tissues and organs, prompting stem cell proliferation and somatic cell dedifferentiation, immunosuppression, and preventing or treating diseases related to nervous disorders and local ischemia.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 13, 2021
    Assignee: Anhui New Star Pharmaceutical Development Co., Ltd.
    Inventors: Xianming Deng, Dawang Zhou, Lanfen Chen, Zhixiang He, Fuqin Fan
  • SUBSTITUTED PENTA-FUSED HEXA-HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, DRUG COMBINATION AND USE THEREOF
    Publication number: 20200165246
    Abstract: A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.
    Type: Application
    Filed: August 3, 2018
    Publication date: May 28, 2020
    Applicant: Xiamen University
    Inventors: Xianming Deng, Wei Huang, Xihuan Sun, Ting Zhang, Zhixiang He, Yan Liu, Xinrui Wu, Baoding Zhang, Xiaoyang Li, Jingfang Zhang, Yun Chen, Li Li, Qingyan Xu, Zhiyu Hu
  • PYRIMIDINE SEVEN-MEMBERED-RING COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF
    Publication number: 20200115386
    Abstract: The present invention relates to compounds (I) capable of inhibiting the Mst1/2 protein kinase activity, a preparation method therefor, a pharmaceutical composition comprising the compounds, and uses of the compounds and the pharmaceutical composition comprising the compounds in the preparation of drugs for prompting repair and regeneration of tissues and organs, prompting stem cell proliferation and somatic cell dedifferentiation, immunosuppression, and preventing or treating diseases related to nervous disorders and local ischemia.
    Type: Application
    Filed: March 2, 2017
    Publication date: April 16, 2020
    Applicant: Anhui New Star Pharmaceutical Development Co., Ltd .
    Inventors: Xianming Deng, Dawang Zhou, Lanfen Chen, Zhixiang He, Fuqin Fan
  • Human head detection in depth images
    Patent number: 9996731
    Abstract: Systems, devices and methods are described including receiving a depth image and applying a template to pixels of the depth image to determine a location of a human head in the depth image. The template includes a circular shaped region and a first annular shaped region surrounding the circular shaped region. The circular shaped region specifies a first range of depth values. The first annular shaped region specifies a second range of depth values that are larger than depth values of the first range of depth values.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: June 12, 2018
    Assignee: Intel Corporation
    Inventors: Wei Hu, Zhixiang He
  • HUMAN HEAD DETECTION IN DEPTH IMAGES
    Publication number: 20150332466
    Abstract: Systems, devices and methods are described including receiving a depth image and applying a template to pixels of the depth image to determine a location of a human head in the depth image. The template includes a circular shaped region and a first annular shaped region surrounding the circular shaped region. The circular shaped region specifies a first range of depth values. The first annular shaped region specifies a second range of depth values that are larger than depth values of the first range of depth values.
    Type: Application
    Filed: July 13, 2015
    Publication date: November 19, 2015
    Inventors: Wei Hu, Zhixiang He
  • Human head detection in depth images
    Patent number: 9111131
    Abstract: Systems, devices and methods are described including receiving a depth image and applying a template to pixels of the depth image to determine a location of a human head in the depth image. The template includes a circular shaped region and a first annular shaped region surrounding the circular shaped region. The circular shaped region specifies a first range of depth values. The first annular shaped region specifies a second range of depth values that are larger than depth values of the first range of depth values.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: August 18, 2015
    Assignee: INTELCORPORATION
    Inventors: Wei Hu, Zhixiang He
  • HUMAN HEAD DETECTION IN DEPTH IMAGES
    Publication number: 20130272576
    Abstract: Systems, devices and methods are described including receiving a depth image and applying a template to pixels of the depth image to determine a location of a human head in the depth image. The template includes a circular shaped region and a first annular shaped region surrounding the circular shaped region. The circular shaped region specifies a first range of depth values. The first annular shaped region specifies a second range of depth values that are larger than depth values of the first range of depth values.
    Type: Application
    Filed: September 30, 2011
    Publication date: October 17, 2013
    Applicant: Intel Corporation
    Inventors: Wei Hu, Zhixiang He