Abstract: The present invention belongs to the medical field, and relates to novel ?-lactamase inhibitors, for the treatment of bacterial infections in combination with ?-lactam antibiotics, including infection caused by drug resistant organisms and especially multi-drug resistant organisms. The present invention includes compounds according to formula (I): or pharmaceutically acceptable salts thereof, wherein M and R are as defined herein.

Abstract: A calculation method of limit load, deformation and energy dissipating of a ring net panel of a flexible protection net, includes step (1): determining geometrical parameters of the ring net, connection type of steel rings, and diameter of steel wires; step (2): determining a loading rate, a loaded region and a boundary condition of the ring net panel; step (3): obtaining basic mechanical parameters of materials through tests, and establishing a critical damage criterion of the ring net panel; step (4): establishing an equivalent calculation model of a ring net panel based on a fiber-spring unit; and step (5): calculating a puncturing displacement, a puncturing load and energy dissipating of the ring net panel. The method adopts a calculation assumption of load path equivalence.

Abstract: A two-stage energy dissipation type shed tunnel support structure connected by a principle of Dougong and a design method thereof are provided. The two-stage energy dissipation type shed tunnel support structure includes a Dougong joint domain, crossbeams and columns. The Dougong joint domain includes section steel members, wavy-wall cylindrical elastoplastic buffers, U-shaped sliding connecting troughs and high-strength bolts. Multiple layers of the section steel members are orthogonally stacked to form a Dougong shape, the wavy-wall cylindrical elastoplastic buffers are arranged between adjacent layers of the section steel members, and the U-shaped sliding connecting troughs are arranged at upper and lower ends of the wavy-wall cylindrical elastoplastic buffers, which realizes a connection between the wavy-wall cylindrical elastoplastic buffers and a section steel in two orthogonal directions.

Abstract: The present invention discloses a shed tunnel structure for preventing a falling rock, including a shed tunnel body and a buffer plate for bearing impact of the falling rock, where the shed tunnel body includes a first supporting structure, and the first supporting structure is arranged on a side away from a ramp; one end of the buffer plate is connected to the ramp; a side face of the buffer plate close to the shed tunnel body is in movable contact with the first supporting structure, and the contact position is close to the other end of the buffer plate. The objective of resisting continuous impact of the falling rock can be achieved through the structural design.

Abstract: A flexible glass protective net with landscape function for falling objects and a design method thereof includes flexible support ropes, buckling clamps, articulated pieces, glass plates and seam rubber strips; the flexible support ropes are arranged crosswise in a grid shape, the buckling clamps are arranged at grid nodes, and the glass plates are arranged in the grids; the glass plate includes pieces of glass, and the pieces of glass are connected by the seam rubber strips at seams; the glass is clamped and fixed by the articulated piece, the tail end of the articulated piece is connected to the buckling clamp, and the glass plate is connected to the buckling clamp via the articulated piece; mutually crossing and separated slots are reserved in the buckling clamps, and the flexible support ropes at the grid nodes respectively pass through the slots.

Abstract: An expandable modular energy-dissipation protection net unit group includes support columns each provided at each of two ends of each support column with a first horizontal longitudinal rotation reversing device on the left side, a second horizontal longitudinal rotation reversing device on the right side and a transverse rotation reversing device on the bottom; a transverse endless support rope, a longitudinal endless support rope and connectors. The transverse endless support rope is wound on the transverse rotation reversing device. The longitudinal endless support rope is wound on the first horizontal longitudinal rotation reversing device and the second horizontal longitudinal rotation reversing device adjacent. A metal net panel is tied by the plurality of connecting members and hung on the transverse endless support rope and the longitudinal endless support rope.

Abstract: A combined type flexible glass net system used for protection against full-particle falling rocks on plank roads in scenic spots includes a supporting layer, an intercepting throwing layer and a flexible glass net isolating layer, wherein the supporting layer is longitudinally arranged above a protective area along a mountain, and includes a supporting steel frame and an oscillating type supporting rod; the intercepting throwing layer is supported on the supporting layer, and includes metal meshes, an along-cross-slope upper connecting rope, an along-cross-slope lower connecting rope, an along-slope connecting rope and a reinforcing rope; and the flexible glass net isolating layer includes glass plates, glass net supporting cables and a hoop type hinged piece, wherein the glass plates are connected to the glass net supporting cables through the hoop type hinged piece, and the glass net supporting cables are hung below the supporting steel frame.

Abstract: A throwing toughness buffer mesh unit for a rockfall protection and a design method of a critical throwing angle thereof are provided. The throwing toughness buffer mesh unit includes a cable column, wherein the cable column is provided with a sliding device on a top end and connected to a foundation structure via a hinged support at a bottom; a support rope, wherein the support rope is connected to the sliding device on the cable column in a sliding way and provided with a spring buffer on an end, wherein the spring buffer is obliquely anchored to a rock mass base near a protection structure; a protection net, which is obliquely hung on the support rope via a connector. A pavement inclination angle of the protection net is adjusted to a critical throwing angle by adjusting a height difference between cable columns to control a throwing track of falling rocks.

Abstract: A two-stage energy dissipation type shed tunnel support structure connected by a principle of Dougong and a design method thereof are provided. The two-stage energy dissipation type shed tunnel support structure includes a Dougong joint domain, crossbeams and columns. The Dougong joint domain includes section steel members, wavy-wall cylindrical elastoplastic buffers, U-shaped sliding connecting troughs and high-strength bolts. Multiple layers of the section steel members are orthogonally stacked to form a Dougong shape, the wavy-wall cylindrical elastoplastic buffers are arranged between adjacent layers of the section steel members, and the U-shaped sliding connecting troughs are arranged at upper and lower ends of the wavy-wall cylindrical elastoplastic buffers, which realizes a connection between the wavy-wall cylindrical elastoplastic buffers and a section steel in two orthogonal directions.

Abstract: A dry process connected energy-consuming beam column joint based on a corbel includes a prefabricated concrete corbel column, pre-buried steel plates and connecting steel plates, wherein the corbel section of the prefabricated concrete corbel column is stepped, and a notch section of a prefabricated concrete notch beam is matched with the stepped section of the corbel and is in lap joint to the stepped section; the pre-buried steel plates are separately pre-buried on the upper and lower surfaces of the corbel and the prefabricated concrete notch beam, friction plates are arranged outside the pre-buried steel plates, and slight tooth spaces are arranged on the sides, facing the pre-buried steel plates, of the friction plates; and the connecting steel plates are arranged on the left and right sides of the prefabricated concrete notch beam and the corbel lap joint section.

Abstract: An expandable modular energy-dissipation protection net unit group includes support columns each provided at each of two ends of each support column with a first horizontal longitudinal rotation reversing device on the left side, a second horizontal longitudinal rotation reversing device on the right side and a transverse rotation reversing device on the bottom; a transverse endless support rope, a longitudinal endless support rope and connectors. The transverse endless support rope is wound on the transverse rotation reversing device. The longitudinal endless support rope is wound on the first horizontal longitudinal rotation reversing device and the second horizontal longitudinal rotation reversing device adjacent. A metal net panel is tied by the plurality of connecting members and hung on the transverse endless support rope and the longitudinal endless support rope.

Abstract: A calculation method of limit load, deformation and energy dissipating of a ring net panel of a flexible protection net, includes step (1): determining geometrical parameters of the ring net, connection type of steel rings, and diameter of steel wires; step (2): determining a loading rate, a loaded region and a boundary condition of the ring net panel; step (3): obtaining basic mechanical parameters of materials through tests, and establishing a critical damage criterion of the ring net panel; step (4): establishing an equivalent calculation model of a ring net panel based on a fiber-spring unit; and step (5): calculating a puncturing displacement, a puncturing load and energy dissipating of the ring net panel. The method adopts a calculation assumption of load path equivalence.

Abstract: A dry process connected energy-consuming beam column joint based on a corbel includes a prefabricated concrete corbel column, pre-buried steel plates and connecting steel plates, wherein the corbel section of the prefabricated concrete corbel column is stepped, and a notch section of a prefabricated concrete notch beam is matched with the stepped section of the corbel and is in lap joint to the stepped section; the pre-buried steel plates are separately pre-buried on the upper and lower surfaces of the corbel and the prefabricated concrete notch beam, friction plates are arranged outside the pre-buried steel plates, and slight tooth spaces are arranged on the sides, facing the pre-buried steel plates, of the friction plates; and the connecting steel plates are arranged on the left and right sides of the prefabricated concrete notch beam and the corbel lap joint section.

Abstract: An arbitrary-shaped fabricated test block for a high-steep slope rolling stone test includes a connecting square barrel and test block bodies. The connecting square barrel is formed by enclosing steel plates, the steel plates are provided with connecting grooves on a periphery of the steel plates, and the connecting grooves are provided with connecting groove bolt holes. The test block bodies are printed on printing bases by 3D printing technology, connecting plates are fixedly arranged on the printing bases, connecting plate bolt holes are formed in the connecting plates, and high-strength bolts penetrate through the connecting groove bolt holes and the connecting plate bolt holes to connect the test block bodies to the connecting square barrel. A sensor box is fixedly arranged on an inner side of the connecting square barrel, and a sensor is arranged in the sensor box.

Abstract: Embodiments of the present invention disclose a video decoding method, where the method includes: respectively converting a transform unit and a prediction unit that are obtained after decoding of a video compression bitstream into an M×M residual block and an M×M prediction block, where M=16, 8, or 4, and the video compression bitstream includes any one of an HEVC bitstream, a VP9 bitstream, and an AVS2.0 bitstream; obtaining a reconstructed picture block according to the residual block and the prediction block; and obtaining a decoded reconstructed picture by performing filtering on the reconstructed picture block. The embodiments of the present invention further disclose a video decoder. The present invention is used to reduce module development of a multi-protocol video decoder and reduce dimensions and power consumption of the video decoder.