Abstract: Embodiments of this application relate to a virtual reality display device. The virtual reality display device includes a left lens barrel and a right lens barrel; the left lens barrel includes: a left lens barrel housing, a left display screen, and a left lens; the right lens barrel includes: a right lens barrel housing, a right display screen, and a right lens; an inner side of an opening portion of the left lens barrel housing includes a left lens holder; an inner side of an opening portion of the right lens barrel housing includes a right lens holder; a left fill layer is provided between the left lens holder and the left lens; and a right fill layer is provided between the right lens holder and the right lens.

Abstract: Provided are heterodimeric proteins comprising polypeptides having CH3 domains with engineered residues that form disulfide bonds and/or salt bridges. Also provided are activatable antibodies targeting CD3 and/or HER2. Compositions, methods of manufacture and methods of treatment using the heterodimeric proteins and the activatable antibodies are further provided.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: A femur fixation device includes an intramedullary nail having along its longitudinal axis a proximal portion, a distal portion and a lateral through hole extending through the proximal portion; and a hip screw capable of passing through the lateral through hole. An axis of the lateral through hole intersects the longitudinal axis at a first inclination angle. The proximal portion includes a first through hole. The first through hole is provided with a detachable positioning bracket therein. A positioning protrusion is defined at a lower end of one side of the positioning bracket. A line connecting the positioning protrusion and corresponding end points on a sidewall of the positioning bracket intersects the longitudinal axis at a second inclination angle. An outer surface of the hip screw is provided with a positioning groove. A tail nail is disposed in the first through hole.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: Compounds of Formulae I, II, their pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formulae I or II as effective modulators of STING are also provided.

Abstract: The present invention discloses a blade structure, a hip screw and a femur fracture treatment device. The blade structure's body has a centrally radially symmetrical cross section. The centrally radially symmetrical cross section has a plurality of centrally radially symmetrical sections, on each of the section at least a cutting slot and two blades formed at corresponding top ends of two sides of the cutting slot respectively are defined, and a projection of a top end of each blade is located on a bottom wall of an interior of the cutting slot.

Abstract: A femur fixation device includes an intramedullary nail having along its longitudinal axis a proximal portion, a distal portion and a lateral through hole extending through the proximal portion; and a hip screw capable of passing through the lateral through hole. An axis of the lateral through hole intersects the longitudinal axis at a first inclination angle. The proximal portion includes a first through hole. The first through hole is provided with a detachable positioning bracket therein. A positioning protrusion is defined at a lower end of one side of the positioning bracket. A line connecting the positioning protrusion and corresponding end points on a sidewall of the positioning bracket intersects the longitudinal axis at a second inclination angle. An outer surface of the hip screw is provided with a positioning groove. A tail nail is disposed in the first through hole.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: A digital glitch filter for filtering glitches in an input signal includes a first flip-flop for generating a filtered output signal, and a self-oscillating circuit for generating a self-oscillating clock signal. A first logic gate enables the self-oscillating circuit when the filtered output signal is not equal to the input signal. A ripple counter generates a divided clock signal by dividing the self-oscillating clock signal. A counter and comparator counts the divided clock signal to obtain a count number and compares the count number with a predetermined count target. A second flip-flop, which is connected to the counter and comparator, generates a valid signal, which is activate when the count number reaches the count target. The valid signal is input to the first flip-flop such that the filtered output signal toggles when the valid signal is active.

Abstract: A digital glitch filter for filtering glitches in an input signal includes a first flip-flop for generating a filtered output signal, and a self-oscillating circuit for generating a self-oscillating clock signal. A first logic gate enables the self-oscillating circuit when the filtered output signal is not equal to the input signal. A ripple counter generates a divided clock signal by dividing the self-oscillating clock signal. A counter and comparator counts the divided clock signal to obtain a count number and compares the count number with a predetermined count target. A second flip-flop, which is connected to the counter and comparator, generates a valid signal, which is activate when the count number reaches the count target. The valid signal is input to the first flip-flop such that the filtered output signal toggles when the valid signal is active.

Abstract: Compounds of Formula I or pharmaceutically acceptable salts or esters thereof capable of binding to and modulating the activity of a stimulator of interferon genes (STING) protein are provided. Methods involving compounds of Formula I as effective modulators of STING are also provided.

Abstract: A lock pin type central nail device has a hollow screw and a central nail, the external revolution surface of the hollow screw is provided with a first external thread segment, a central hole is arranged in the hollow screw in a axially penetrating manner, and the central nail is adaptively mounted into the central hole of the hollow screw, so that the hollow screw and the central nail (20) are mounted together.