Abstract: The present disclosure provides an N protein epitope mutation marker for preparing an epitope deletion-marked vaccine strain of type II porcine reproductive and respiratory syndrome virus (PRRSV) and use thereof, belonging to the technical field of biological products. In the mutation marker, one or more amino acids are mutated based on an epitope sequence at positions 92 to 103 of a C-terminal of an N protein of the type II PRRSV; and the epitope mutation marker has an amino acid sequence shown in SEQ ID NO: 1, where X1 is selected from the group consisting of T, P, and A; and X2 is selected from the group consisting of V and A.

Abstract: According to embodiments of the present invention, a method of forming a fiber-shaped structure is provided. The method includes subjecting a precursor material arrangement to a thermal drawing process to form the fiber-shaped structure, the precursor material arrangement including a preform of a first material having a first melting point, and a second material in an interior space of the preform, the second material having a second melting point that is higher than the first melting point, wherein the thermal drawing process includes subjecting the preform and the second material to a heating process to heat the preform to a molten state for forming the fiber-shaped structure, wherein the second material that is heated remains in a solid state, and wherein the fiber-shaped structure that is formed includes the first material and the second material.

Abstract: The present invention is directed to novel pleuromutilin antibiotic compounds, intermediates which are useful for making these novel antibiotic compounds, methods of synthesizing these compounds and related methods and pharmaceutical compositions for treating pathogens» especially bacterial infections, including gram negative bacteria.