Patents by Inventor Zhiyong Chen
Zhiyong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170037059Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.Type: ApplicationFiled: September 16, 2016Publication date: February 9, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Christopher J. Creighton, Leslie William Tari, Zhiyong Chen, Mark Hilgers, Thanh To Lam, Xiaoming Li, Michael Trzoss, Junhu Zhang, John Finn, Daniel Bensen
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Publication number: 20170002001Abstract: Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.Type: ApplicationFiled: June 17, 2016Publication date: January 5, 2017Inventors: Yunfei ZHU, Jian ZHAO, Zhiyong CHEN
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Patent number: 9481675Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.Type: GrantFiled: September 10, 2010Date of Patent: November 1, 2016Assignee: Merck Sharp & Dohme Corp.Inventors: Christopher J Creighton, Leslie William Tari, Zhiyong Chen, Mark Hilgers, Thanh To Lam, Xiaoming Li, Michael Trzoss, Junhu Zhang, John Finn, Daniel Bensen
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Publication number: 20160222015Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: ApplicationFiled: September 10, 2014Publication date: August 4, 2016Applicants: Merck Sharp & Dohme Corp., Lawrence Livermore National Security, LLCInventors: John Finn, Leslie William Tari, Zhiyong Chen, Junhu Zhang, Douglas Phillipson, Suk Joong Lee, Michael Trzoss, Daniel Bensen, Xiaoming Li, Min Teng, Voon Ong, Allen John Borchardt, Thanh To Lam, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen
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Patent number: 9398713Abstract: Embodiment of the invention discloses an electronic apparatus. A frame of the electronic apparatus comprises a sense region, and at least one sense window is provided in the sense region. A reflection type optical emitter-receiver-tube is provided at a position inside the electronic apparatus corresponding to the sense window, and an output terminal of the optical emitter-receiver-tube is connected with a processor inside the electronic apparatus.Type: GrantFiled: August 15, 2013Date of Patent: July 19, 2016Assignee: BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD.Inventors: Zhiyong Chen, Zhuang Wang
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Publication number: 20160153869Abstract: A silty floating mud collection device, which includes a drive cylinder, an outer sleeve, a sampler barrel, an lug cover plate, a turning cover, a control ring and a control rod, where the drive cylinder includes a cylinder liner, a piston and a piston rod; the outer sleeve is fixedly connected below the cylinder liner; the sampler barrel is detachably installed inside the outer sleeve; the lug cover plate is fixedly connected to a lower end of the piston rod, and can close an upper-end opening of the sampler barrel; the turning cover is turnably installed at a lower end of the outer sleeve, and can close a lower-end opening of the sampler barrel; the control ring is located below the sampler barrel, and is used to block the turning cover which is in an open state; and an upper end of the control rod is connected to the lug cover plate, and a lower end of the control rod is connected to the control ring.Type: ApplicationFiled: November 14, 2013Publication date: June 2, 2016Inventors: JIANDING NIU, JIANPING HU, ZHIYONG CHEN, ZEKUN CHENG, LIMIN CHENG, XIAOJIE LI, JIAOSHE DONG, NIANXI WANG, ZHAOMING WANG
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Publication number: 20160130685Abstract: Disclosed are a lead-free, high-sulphur and easy-cutting copper-manganese alloy and preparation method thereof. The alloy comprises the following components in percentage by weight: 52.0-95.0 wt. % of copper, 0.01-0.20 wt. % of phosphorus, 0.01-20 wt. % of tin, 0.55-7.0 wt. % of manganese, 0.191-1.0 wt. % of sulphur, one or more metals other than zinc that have an affinity to sulphur less than the affinity of manganese to sulphur, with the sum of the contents thereof no more than 2.0 wt. %, and the balance being zinc and inevitable impurities, wherein the metals other than zinc that have an affinity to sulphur less than the affinity of manganese to sulphur are nickel, iron, tungsten, cobalt, molybdenum, antimony, bismuth and niobium.Type: ApplicationFiled: September 4, 2013Publication date: May 12, 2016Applicant: HUNAN TERRY NEW MATERIALS COMPANY LTD.Inventors: Jinsong HUANG, Bin LIU, Wei LI, Zhiyong CHEN, Tao PENG
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Patent number: 9221178Abstract: A live working robot for replacing insulator string comprises four parts including a locating mechanism, a clamping mechanism, a transmission mechanism and working condition indicating lamps. The robot is supported to operate in a horizontal plane by an insulating pole. The robot is hung in a vertical plane to support operation by an insulating rope. The locating mechanism can grip a socket accurately, which can be indicated in place by a horizontally positioned lamp and a vertically positioned lamp. The clamping mechanism can clamp a W-pin for disassembling and assembling. The transmission mechanism can transmit the clamping mechanism to clamp, release, advance and retreat the clamp. Placement and clamping of the clamp can be indicated with a clamping position lamp and a limiting lamp. The live working robot can replace the insulator string without the need of power cut, is in simple structure, works reliably and accurately and is time and labor saving.Type: GrantFiled: November 5, 2012Date of Patent: December 29, 2015Assignees: SHANXI ELECTRIC POWER COMPANY TAIYUAN POWER SUPPLY COMPANY, STATE GRID CORPORATION OF CHINA, SHANXI GREAT WALL ELECTRICAL AND MECHANICAL RESEARCH INSTITUTEInventors: Junliu Zhang, Zhiyong Chen, Nianjun Zhang, Zongze Huang, Jinping Wang, Xingyu Ma
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Publication number: 20150246934Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: ApplicationFiled: September 11, 2013Publication date: September 3, 2015Inventors: Daniel Bensen, Allen Borchardt, Zhiyong Chen, John M. Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Leslie William Tari, Min Teng, Michael Trzoss, Junhu Zhang, Michael E. Jung, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen
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Patent number: 9051880Abstract: A system includes a cooler configured to cool a first gas portion of a compressed gas fuel and discharge a cooled fluid. The cooled fluid comprises a cooled gas portion and a cooled liquid portion. The system also includes a separator configured to separate the cooled fluid into the cooled gas portion and the cooled liquid portion and a mixing tank configured to mix a second gas portion of the compressed gas fuel with the cooled gas portion in direct contact with one another to produce a superheated gas fuel. The superheated gas fuel comprises a degree of superheat above a lower threshold for a combustion system.Type: GrantFiled: September 19, 2011Date of Patent: June 9, 2015Assignee: General Electric CompanyInventors: Wenjie Wu, Ping Yu, Yuan Tian, Zhiyong Chen
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Patent number: 8973565Abstract: An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.Type: GrantFiled: August 8, 2012Date of Patent: March 10, 2015Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Zhiyong Chen, Zhilin Liao, Frank C. Tortella, Xi-Chun May Lu, Jitendra R. Dave, Jay E. Bartlett, Mark F. Arnold, Mark P. Easterday, Mark W. Brown, Larry R. Holmes, Zachary J. Larimore, Kara E. Schmid, Deborah A. Shear, Lai Yee Leung, Andrea Mountney
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Publication number: 20140343458Abstract: An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.Type: ApplicationFiled: July 24, 2014Publication date: November 20, 2014Applicant: The Government of the United States as represented by the Secretary of the ArmyInventors: Zhiyong Chen, Zhilin Liao, Frank C. Tortella, Xi-Chun May Lu, Jitendra R. Dave, Jay E. Bartlett, Mark F. Arnold, Mark P. Easterday, Mark W. Brown, Larry R. Holmes, Zachary J. Larimore, Kara E. Schmid, Deborah A. Shear, Lai Yee Leung, Andrea Mountney
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Patent number: 8835445Abstract: The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.Type: GrantFiled: June 2, 2011Date of Patent: September 16, 2014Assignee: Trius Therapeutics, Inc.Inventors: Zhiyong Chen, Christopher J. Creighton, Mark Cunningham, John Finn, Mark Hilgers, Michael Jung, Lucy Aguirre Kohnen, Thanh Lam, Xiaoming Li, Mark Stidham, Les Tari, Michael Trzoss, Junhu Zhang
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Publication number: 20140049885Abstract: Embodiment of the invention discloses an electronic apparatus. A frame of the electronic apparatus comprises a sense region, and at least one sense window is provided in the sense region. A reflection type optical emitter-receiver-tube is provided at a position inside the electronic apparatus corresponding to the sense window, and an output terminal of the optical emitter-receiver-tube is connected with a processor inside the electronic apparatus.Type: ApplicationFiled: August 15, 2013Publication date: February 20, 2014Applicant: BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD.Inventors: Zhiyong CHEN, Zhuang WANG
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Publication number: 20130255271Abstract: A fuel supply system is provided having a first fuel gas compressor configured to be driven by a motor and a second fuel gas compressor configured to be driven by a shaft of a gas turbine system. The first fuel gas compressor and the second fuel gas compressor are configured to supply a pressurized fuel flow to a combustor of the gas turbine system, and the first fuel gas compressor and the second fuel gas compressor are coupled to one another in series.Type: ApplicationFiled: February 20, 2013Publication date: October 3, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Ping Yu, Wenjie Wu, Zhiyong Chen
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Publication number: 20130079323Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth.Type: ApplicationFiled: September 10, 2010Publication date: March 28, 2013Applicant: TRIUS THERAPEUTICS, INC.Inventors: Christopher J. Creighton, Leslie William Tari, Zhiyong Chen, Mark Hilgers, Thanh To Lam, Xiaoming Li, Michael Trzoss, Junhu Zhang, John Finn, Daniel Bensen
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Publication number: 20130042332Abstract: An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.Type: ApplicationFiled: August 8, 2012Publication date: February 14, 2013Inventors: Zhiyong Chen, Zhilin Liao, Frank C. Tortella, Xi-Chun May Lu, Jitendra R. Dave, Jay E. Bartlett, Mark F. Arnold, Mark P. Easterday, Mark W. Brown, Larry R. Holmes, Zachary J. Larimore, Kara E. Schmid, Deborah A. Shear, Lai Yee Leung, Andrea Mountney
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Publication number: 20120238751Abstract: Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.Type: ApplicationFiled: March 14, 2012Publication date: September 20, 2012Applicant: TRIUS THERAPEUTICS, INC.Inventors: Daniel Bensen, Zhiyong Chen, John Finn, Thanh To Lam, Suk Joong Lee, Xiaoming Li, Douglas W. Phillipson, Leslie William Tari, Michael Trzoss, Junhu Zhang, Felice C. Lightstone, Toan B. Nguyen, Sergio E. Wong, Paul Aristoff, Michael Jung
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Publication number: 20120204971Abstract: A system includes a cooler configured to cool a first gas portion of a compressed gas fuel and discharge a cooled fluid. The cooled fluid comprises a cooled gas portion and a cooled liquid portion. The system also includes a separator configured to separate the cooled fluid into the cooled gas portion and the cooled liquid portion and a mixing tank configured to mix a second gas portion of the compressed gas fuel with the cooled gas portion in direct contact with one another to produce a superheated gas fuel. The superheated gas fuel comprises a degree of superheat above a lower threshold for a combustion system.Type: ApplicationFiled: September 19, 2011Publication date: August 16, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Wenjie Wu, Ping Yu, Yuan Tian, Zhiyong Chen
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Publication number: 20120136014Abstract: The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.Type: ApplicationFiled: June 2, 2011Publication date: May 31, 2012Applicant: TRIUS THERAPEUTICS, INC.Inventors: Zhiyong Chen, Christopher J. Creghton, Mark Cunningham, John Finn, Mark Hilgers, Michael Jung, Lucy Aguirre Kohnen, Thanh Lam, Xiaoming Li, Mark Stidham, Les Tari, Michael Trzoss, Junhu Zhang