Abstract: The present invention discloses a pharmaceutical composition comprising azvudine and a chemotherapeutic agent. The pharmaceutical composition of the present invention shows a good synergistic effect in antitumor, and can reduce the dosage of chemotherapeutic agent, and improve the therapeutic effect and safety, thereby achieving the goal of prolonging the survival of patients.

Abstract: The present invention discloses the inhibitory effect of azvudine as an immunomodulator on mice bearing CT-26 tumor. It is found that azvudine has no significant anti-tumor effect on immunodeficient B-NDG mice bearing CT-26 tumor, yet has an antitumor effect on BALB/c mice with normal immunity bearing CT-26 tumor model. The present invention further studies the combined effect of azvudine and PD-1 antibody, and finds that compared with a single drug, the combined administration has a synergistic anti-tumor effect.

Abstract: The present invention discloses a pharmaceutical composition comprising azvudine and a chemotherapeutic agent. The pharmaceutical composition of the present invention shows a good synergistic effect in antitumor, and can reduce the dosage of chemotherapeutic agent, and improve the therapeutic effect and safety, thereby achieving the goal of prolonging the survival of patients.

Abstract: The present invention discloses a pharmaceutical composition comprising azvudine and an EGFR/TKI inhibitor. The pharmaceutical composition of the present invention shows a good synergistic effect in antitumor, and can delay the generation of drug resistance and improve the therapeutic effect and safety, thereby achieving the goal of prolonging the survival of patients.

Abstract: An apparatus for efficiently preparing spherical metal powder for 3D printing includes a housing, a crucible and a powder collection area arranged in the housing, wherein a turnplate arranged in the collection area is an inlaid structure. A material having a poor thermal conductivity is selected as the base of the turnplate, and a metal material having a wetting angle less than 90° with respect to droplets is selected and embedded into the base to serve as an atomization plane of the turnplate. An air hole is disposed in the turnplate. The spherical metal powder for 3D printing combines electromagnetic force breaking capillary jet flow and centrifugal atomization, which breaks through the traditional metal split mode, and makes the molten metal in a fibrous splitting.

Abstract: An apparatus includes a housing, a crucible disposed in the housing, and a collection bin. A turnplate disposed in a powder collection area is of an inlaid structure. A concentric circular groove is provided on the atomization plane. An air hole is provided in the turnplate. The present invention combines the pulsated orifice ejection method and the centrifugal atomization method, in cooperation with the turnplate structure and subjecting the turnplate surface to induction heating, so that a metal liquid is allowed to break through the split mode of traditional molten metal, achieves a fibrous split mode that can be implemented only when an atomizing medium is an aqueous or organic solution, and prepares a high-melting-point metal powder that meets requirements, and has a controllable particle size, high sphericity, no satellite droplets, and good flowability and spreadability, and is suitable for industrial production.

Abstract: An apparatus efficiently preparing ultrafine spherical metal powder includes a housing, a crucible and a powder collection area arranged in the housing. The turnplate arranged in the powder collection area is an inlaid structure. The part inlaid into the body part acts as an atomization plane of the turnplate. The atomization plane is provided with a concentric circular groove, and the turnplate is provided with an air hole. The apparatus is used for preparing ultrafine spherical metal powder by on-by-one droplets centrifugal atomization method, mainly combining the uniform droplet jet method and the centrifugal atomization method, which breaks through the traditional metal splitting model, makes the molten metal in a fibrous splitting, so as to efficiently prepare ultrafine spherical metal powder with narrow particle size distribution interval, high sphericity, good flowability, excellent spreadability, uniform and controllable size, no satellite droplets and suitable for industrial production.