Abstract: The disclosure provides a compound of formula (I) and pharmaceutical compositions thereof. The compound of formula (I) of the present disclosure can be used as a degradation agent of cyclin K (CyclinK protein), and can be used to prevent or treat diseases related to CyclinK protein.

Abstract: An nGraph-based graphics processing unit (GPU) backend distributed training method and system, a computer-readable storage medium, and an electronic device. The method includes: receiving a training request, and obtaining corresponding training data; obtaining a Nvidia® Collective multi-GPU Communication Library (NCCL) file by means of a system path of the NCCL file linked to an nGraph framework; invoking an NCCL communication interface configuration according to the training request to obtain a training model, the NCCL communication interface is an NCCL file-based communication operation interface located at a GPU backend of the nGraph framework; and performing GPU backend training on the training data using the training model. The present application can satisfy an urgent need of a user for performing neural network distributed training on the basis of an nGraph GPU backend, thus further improving the performance of deep learning network training.

Abstract: An nGraph-based graphics processing unit (GPU) backend distributed training method and system, a computer-readable storage medium, and an electronic device. The method includes: receiving a training request, and obtaining corresponding training data; obtaining a Nvidia® Collective multi-GPU Communication Library (NCCL) file by means of a system path of the NCCL file linked to an nGraph framework; invoking an NCCL communication interface configuration according to the training request to obtain a training model, the NCCL communication interface is an NCCL file-based communication operation interface located at a GPU backend of the nGraph framework; and performing GPU backend training on the training data using the training model. The present application can satisfy an urgent need of a user for performing neural network distributed training on the basis of an nGraph GPU backend, thus further improving the performance of deep learning network training.

Abstract: Identity and access management may update and remediation may be performed dynamically. Historical user behavior data may be obtained. An account specific baseline based on the historical user behavior data may be generated. An access request may be received from a current user. Current user behavior data associated with a current user may be obtained. The current user behavior data may be compared to the account specific baseline. It may be determined whether the current user behavior data satisfies the account specific baseline. If the current user behavior data satisfies the account specific baseline, an access may be granted to the current user. If the current user behavior data does not satisfy the account specific baseline, access may be denied to the current user.

Abstract: Identity and access management may update and remediation may be performed dynamically. Historical user behavior data may be obtained. An account specific baseline based on the historical user behavior data may be generated. An access request may be received from a current user. Current user behavior data associated with a current user may be obtained. The current user behavior data may be compared to the account specific baseline. It may be determined whether the current user behavior data satisfies the account specific baseline. If the current user behavior data satisfies the account specific baseline, an access may be granted to the current user. If the current user behavior data does not satisfy the account specific baseline, access may be denied to the current user.

Abstract: A hair straightener heating element comprises: a base, a working plate, a heating sheet, a thermal insulation sheet, and a silica gel pad. The base is provided with an accommodation groove thereon. The silica gel pad is arranged in the accommodation groove. The thermal insulation sheet is fitted into the silica gel pad. The heating sheet is arranged on the thermal insulation sheet. The working plate has an inverted “U” shape, and cooperates with the base to sandwich the heating sheet, the thermal insulation sheet and the silica gel pad between the working plate and the base. The heating sheet is attached and matches a bottom surface of the working plate. The heating element separates a frame and a working plate into two devices, and provides a good contact between a heating sheet and the working plate so as to be isolated from the frame. The heating sheet immediately conducts heat to the working plate, and rapidly raises the temperature of the working plate, thereby enhancing a heating rate.

Abstract: The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.

Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The housekeeping epitope(s) can be derived from a target-associated antigen, and the housekeeping epitope can be liberatable, that is capable of liberation, from a translation product of the cassette by immunoproteasome processing. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.

Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The invention relates to epitope cluster regions and to vectors including epitope cluster regions. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.

Abstract: The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.

Abstract: The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.

Abstract: The instant disclosure relates to methods for treating a cancer patient with an active immunotherapeutic, wherein the methods include assessing a patient's pre-existing immunoreactivity to at least one target antigen, choosing an immunotherapeutic regimen based on the level of pre-existing immunoreactivity, and administering an active immunotherapeutic according to the regimen.

Abstract: The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.

Abstract: A method provided by the present invention for transmitting overhead information, includes dividing and reforming overhead information into at least two overhead parts, inserting the at least two overhead parts into overhead bytes of at least two corresponding data frames, and transmitting the at least two overhead parts via the at least two data frames which are microwave frames. Overhead information transmitting apparatus and overhead information receiving apparatus are also provided by the present invention. With the method and apparatus of the present invention, the channel bandwidth resources occupied by the overhead bytes or each microwave frame are greatly reduced. If the saved channel bandwidth is used for performing the error correction code on the transmitted information, the code gain is improved and the sensitivity requirement on the receiver is reduced so that the cost of a microwave transmitting system is reduced eventually.