Abstract: One aspect of the technology relates to methods, assays and kits to identify ischemia and ischemic injury, including kidney injury, and are useful in determining efficacy of cancer treatments. In particular, differential phosphorylation of the nucleophosmin (NPM) polypeptide is an early marker of ischemic injuries such as kidney injury, AKI and ischemic renal cell injury. Another aspect of the technology relates to compositions and methods for the treatment of ischemia and kidney injury, including NPM inhibitory agents, including, but not limited to NPM inhibitory peptides for the treatment of ischemia and kidney injury.

Abstract: A method for performing data recovering operation is provided. The method includes: identifying a plurality of first values and a plurality of first indexes of a plurality of first entries of an incomplete matrix in a received object data, and one or more second values and one or more second indexes of one or more second entries of the incomplete matrix; inputting the first values, the first indexes, a preset first parameter, a preset second parameter and a preset third parameter into an analysis model using Adaptive Rank-One Matrix Completion (AROMC) algorithm; and obtaining a recovered complete matrix corresponding to the incomplete matrix from the analysis model, so as to obtain optimized one or more second values of the second entries, wherein the optimized one or more second values are determined as original values of the second entries, such that the incomplete matrix is recovered to the recovered complete matrix.

Abstract: A calculation method for service life of concrete in a plateau environment considering protection and restoration effects is provided and includes a construction of a model based on a coupling effect of multi-factors of temperature-humidity-salt concentration-load under the plateau environment, simulation of protection and restoration effects, and quantification of service life. The model includes the physical fields of temperature conduction with variable boundary conditions, water dry-wet cycle transport, salt ion transport, and force fields caused by internal and external loads. The simulation of protection and restoration effects include: surface protective coating, damage restoration, and rebar corrosion resistance.

Abstract: A carrier device applied to semiconductor processing equipment includes a base, a carrier element, and a position-limiting ring. The base includes a connection flow channel. a top surface of the base is configured to carry a wafer. The carrier element is stacked with the base and located under the base, a gas flow channel structure is formed between the carrier element and the base. A position-limiting ring structure is sleeved at an outer circumference of the base and configured to limit a position of the wafer. A gas blow cannel and a first uniform flow space are formed between an inner circumferential wall of the position-limiting ring structure and an outer circumferential wall of the base. The first uniform flow space communicates with the gas blow channel.

Abstract: The disclosure provides a compound of formula (I) and pharmaceutical compositions thereof. The compound of formula (I) of the present disclosure can be used as a degradation agent of cyclin K (CyclinK protein), and can be used to prevent or treat diseases related to CyclinK protein.

Abstract: A modified green coke material, a method for preparing the modified green coke material, and an application of the modified green coke material are provided. A sum of percentages of a long fibrous structure and a broad-domain structure in a polarized microstructure of the modified green coke material is in a range of 55˜99%, and a percentage of volatile components in the modified green coke material is in a range of 1%?volatile components matter<5%.

Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

Abstract: A method for improving smooth running of casting of rare earth stainless steel using pulse current includes the following steps: setting corresponding initial pulse voltage, pulse current, and pulse frequency in accordance with difference of rare earth element content in molten steel; and adjusting the pulse voltage, pulse current, and pulse frequency according to position change of stopper rod until the end of continuous casting. The method can stably improve the clogging of immersion nozzle during continuous casting, the smooth running of continuous casting and production efficiency, and decrease production cost.

Abstract: The disclosure provides a joint module and an articulated robot. The joint module comprises a hollow shaft having first and second ends, a speed reducer assembly and a motor assembly sleeved on the hollow shaft, and an encoder assembly. The power output end of the motor assembly is connected to the first end via the speed reducer assembly. The encoder assembly comprises an encoder mounting base, outer, middle, and inner rings, input and output code wheels disposed on the inner ring, and an encoder read head mounted on the encoder mounting base. The inner ring is sleeved on and connected with the second end. The middle ring connected with the power output end is sleeved on the inner ring in a running fit. The outer ring is sleeved on the middle ring in a running fit and connected with the motor assembly via the encoder mounting base.

Abstract: In some implementations, there is provided a method including identifying, from an electronic drawing, at least one object and at least one object location in at least one user intention for a user interface that is responsive across a plurality of screen sizes, wherein the at least one object and the at least one object location are identified using a machine learning model; creating responsive rules for the at least one object and at least one object location detected in the at last one user intention; and rendering, based on the responsive rules, the user interface, such that the responsive rules configure content layout in the user interface in response to a screen size displaying the user interface. Related systems, methods, and articles of manufacture are also disclosed.

Abstract: A multimedia message transmission method includes a network device that obtains at least two multimedia message bodies that are for same content. Sizes of the at least two multimedia message bodies are different. The network device determines hardware information of a terminal device. The network device sends a multimedia message to the terminal device based on the hardware information. The network device sends, to the terminal device, a multimedia message that complies with a multimedia message capability corresponding to the hardware information.

Abstract: Described herein are polypeptides comprising at least one nucleophosmin-binding domain, including engineered polypeptides, and methods of using such polypeptides to treat or prevent acute kidney injury and/or kidney ischemia.

Abstract: Provided is a compound represented by formula (I) and a pharmaceutical composition thereof, as well as a method for using a compound represented by formula (I) to prevent and/or treat immune-related disorders.

Abstract: A hot extrusion die for a special-shaped square pipe includes a die cavity sleeve with a special-shaped cavity. A hot extrusion mandrel is arranged in the die cavity sleeve. An area between the die cavity sleeve and the hot extrusion mandrel forms a die cavity hole. A first extrusion diversion hole and a second extrusion diversion hole are arranged below the die cavity hole. An integral centroid of the die cavity hole is located at a circle center of a radial cross section of the die cavity sleeve. Further disclosed is a hot extrusion integral forming method for a special-shaped square pipe, including: heating and expanding a blank material; heating the blank material again after expanding; performing hot extrusion on the blank material; and cooling the formed special-shaped square pipe in air to a room temperature, and inspecting surface quality and mechanical properties of the special-shaped square pipe.

Abstract: Disclosed are a voice coil for a sound producing device and a sound producing device, the sound producing device comprises a voice coil body and a reinforcing portion; the voice coil body comprises a voice coil framework and a voice coil wire; the reinforcing portion comprises a first reinforcing portion and a second reinforcing portion; the first reinforcing portion is provided on the inner side of the voice coil framework, and the second reinforcing portion is provided on the outer side of the voice coil framework; and the reinforcing portion is configured to enhance the strength of the voice coil at high frequencies. Both the inner side and the outer side of the voice coil framework are provided with the reinforcing portions, thereby preventing the voice coil framework from deforming towards the side with lower strength because the strength of one side of the voice coil framework is relatively low.

Abstract: A display panel has a display region and a frame region outside the display region. The display region includes a plurality of pixel circuits. The display panel includes a base substrate, a buffer layer, a semiconductor layer, a power signal layer, and an auxiliary circuit layer. The buffer layer is on a side of the base substrate. The buffer layer includes an a-Si layer. The semiconductor layer is on a side of the buffer layer away from the base substrate. The power signal layer is on a side of the semiconductor layer away from the base substrate. The power signal layer includes a plurality of first power voltage lines in the display region, and one first power voltage line of the plurality of first power voltage lines are electrically connected to a corresponding pixel circuit.

Abstract: The present invention discloses the inhibitory effect of azvudine as an immunomodulator on mice bearing CT-26 tumor. It is found that azvudine has no significant anti-tumor effect on immunodeficient B-NDG mice bearing CT-26 tumor, yet has an antitumor effect on BALB/c mice with normal immunity bearing CT-26 tumor model. The present invention further studies the combined effect of azvudine and PD-1 antibody, and finds that compared with a single drug, the combined administration has a synergistic anti-tumor effect.

Abstract: The present invention discloses a pharmaceutical composition comprising azvudine and a chemotherapeutic agent. The pharmaceutical composition of the present invention shows a good synergistic effect in antitumor, and can reduce the dosage of chemotherapeutic agent, and improve the therapeutic effect and safety, thereby achieving the goal of prolonging the survival of patients.

Abstract: The present disclosure relates to a device, method and system for calculating, estimating, or monitoring the blood pressure of a subject. At least one processor, when executing instructions, may perform one or more of the following operations. A first signal representing heart activity of the subject may be received. A second signal representing time-varying information on at least one pulse wave of the subject may be received. A first feature in the first signal may be identified. A second feature in the second signal may be identified. A pulse transit time based on a difference between the first feature and the second feature may be computed. The blood pressure of the subject may be calculated according to a first model based on the computed pulse transit time and a first set of calibration values, the first set of calibration values relating to the subject.