Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: The present invention provides a method for preparing a high molecular polymer powder material comprising the following steps: adding 20 parts of a high molecular powder material and 0.1 to 10 parts of carbon black into a mixing tank, and performing high-speed stirring for the first time to obtain a high molecular carbon black mixed powder material; adding the high molecular carbon black mixed powder material, 0.1 to 1 part of a flow aid, and 80 parts of a polymer powder material into the powder mixing tank; and performing high-speed stirring for a second time followed by sieving to obtain the high molecular polymer powder material.

Abstract: The present invention discloses an inner lining sheet for a sanitary cigarette case, disposed between a cigarette case body and an aluminum foil paper, in which four fold lines including two transverse and two longitudinal fold lines, are formed on the inner lining sheet, in which the front and rear transverse fold lines, both located in the middle part of the inner lining sheet, are parallel to each other, and the left and right longitudinal fold lines, both located below the transverse fold line, are parallel to each other; thus dividing the inner lining sheet into five parts including a front surface, a left side surface, a right side surface, a rear surface and an enclosure surface, in which an enclosure surface is formed by a part defined between the front and rear transverse fold lines, a top edge of the left side surface is lower than the front transverse fold line and a top edge of a left part of the front surface is also lower than the front transverse fold line.

Abstract: A package for cigarettes, including a sanitary cigarette case which can avoid filter tips from being contacted by fingers, so preventing germs on the fingers from spreading into the mouth via the filter tips. The case can include a case body and a case cover and an opening surface of the case body that is parallel with the longitudinal axis of cigarettes. The opening end of the case body can be covered by the case cover, which has a concavity in its longer face. An advantage of this cigarette case is that it is designed so that person can grasp the middle of a cigarette when they remove the cigarette from the cigarette case, thereby preventing the filter tips from being contacted by the fingers, and preventing germs on the fingers from spreading into the mouth via the filter tips. This cigarette case can have a sanitary, convenient, elegant operation, simple manufacturing process and low cost.

Abstract: A package for cigarettes, in particularly, a sanitary cigarette case which can avoid filter tips from being contacted by fingers, so avoiding germs on fingers from spreading into mouth through filter tips, includes a case body and a case cover and is characterized in that the opening surface of the case body is parallel with the longitudinal axis of cigarettes, the opening end of the case body is covered by the case cover, which has a concavity in its longer face. The advantage of this cigarette case is that it is designed in such a configuration so that person can only put the middle of cigarette when they nick cigarette out of cigarette case, thereby avoiding filter tips from being contacted by fingers, so preventing germs on fingers from spreading into mouth through filter tips. Therefore, this cigarette case has sanitary, convenience, elegant operation, simple process and low cost.