Abstract: Secure printing may be performed in a virtual desktop infrastructure (VDI) in a virtualized computing environment. When a file is selected for secure printing, print data for the file is stored, and a corresponding entry is created in a metadata map. A message is sent to a user device to inform a user that the file is available for secure printing. The message may include a uniform resource locator (URL) link having a hash code corresponding to the stored print data. If the user accesses the URL link to request the secure printing, the hash code is retrieved from the URL link and compared against the entry in the metadata map. If there is a match between the hash code and the entry in the metadata map, the file is sent to a target local printer for printing.

Abstract: The present disclosure provides a forced forming apparatus for a plurality of welds in a narrow space, belonging to the field of welding technology, and the apparatus includes a plurality of first backing members arranged adjacent to one another, and second backing member group structures configured to interconnect every two adjacent first backing members; each of the second backing member group structures is used for adjusting a distance between two adjacent first backing members; and a frame enclosed by the first backing members and the second backing member group structures is configured to be clamped on back sides of welds of a workpiece to be welded; and the first backing members and the second backing member group structures are both provided with forming arced faces, and the forming arced faces are arranged opposite to the welds of the workpiece to be welded.

Abstract: The present disclosure provides a method for rapid and harmless treatment of a livestock and poultry carcass/residue by a bacterium-enzyme complex and relates to the technical field of dead livestock and poultry treatment. In the present disclosure, a composite microbial inoculant is compounded from protease-, lipase-, and keratinase-producing strains, and can be applied to the degradation of fats and proteins as well as deodorization. The composite microbial inoculant is further combined with a protease preparation and a lipase preparation to prepare the bacterium-enzyme complex. The bacterium-enzyme complex can quickly and harmlessly treat the carcasses/residues of pig, cattle, sheep, and chicken, and has a short treatment period, mild and controllable reaction conditions, and safe and non-toxic reaction process and reaction products. During the reaction, harmful gases such as CH4 and NH3 and greenhouse gases such as CO2 released by the method are less than those by other methods.

Abstract: Secure printing may be performed in a virtual desktop infrastructure (VDI) in a virtualized computing environment. When a file is selected for secure printing, print data for the file is stored, and a corresponding entry is created in a metadata map. A message is sent to a user device to inform a user that the file is available for secure printing. The message may include a uniform resource locator (URL) link having a hash code corresponding to the stored print data. If the user accesses the URL link to request the secure printing, the hash code is retrieved from the URL link and compared against the entry in the metadata map. If there is a match between the hash code and the entry in the metadata map, the file is sent to a target local printer for printing.

Abstract: A structural analog of Cyclotheonellazole A, and a synthetic method therefor and an application method thereof are provided. A compound with a structure of formula (I) and a pharmaceutically acceptable salt thereof are provided. The formula (I) is as follows: R1, R2, R3 and R4 are independently selected form the group consisting of H, a C1-C6 alkyl group, a C1-C6 alkoxy group, a halogen group, a hydroxyl group, an amino group, a nitro group, a cyano group, and a sulfydryl group. Based on the total synthetic route of Cyclotheonellazole A, the classical reverse synthesis analysis is utilized, the structural modification is purposefully carried out, a mother nucleus of the natural product remains unchanged, and the structural analog 1a is obtained by replacing a left side chain with a simple formylamine, thereby confirming the excellent protease inhibitory activity thereof, and having a strong application prospect in the pharmaceutical industry.

Abstract: Disclosed are a pyrido ring compound, a preparation method therefor, an intermediate, a composition, and an application. The pyrido ring compound has a structure as shown in formula I, has JAK inhibitory activity, and can be used for treating JAK-related diseases, such as autoimmune diseases or cancers.

Abstract: A synthetic compound of myricetin and nobiletin, and a preparation method therefor are provided, two clinically significant lead compounds of the myricetin and the nobiletin are modified, a new synthetic compound of myricetin and nobiletin is obtained. Compared with traditional western medicine, the new synthetic compound has significant advantages in treating comorbidities and has fewer adverse reactions. The reduction of serum uric acid and creatinine levels by the synthetic compound of myricetin and nobiletin is significantly higher than that of monomers myricetin and monomers nobiletin, which indicates that the synthetic compound of myricetin and nobiletin has a better uric acid lowering effect than monomeric medicines and has a significant improvement effect on hyperuricemia (HUA).

Abstract: The invention discloses small molecular compounds targeting SRSF6 protein, its preparation method and applications. The compound is shown in formula (I). This molecule can selectively inhibit abnormal cells with high expression of SRSF6, thereby reducing the occurrence of abnormal alternative splicing events and inhibiting the occurrence and development of tumors, especially colorectal tumors. It can be used as a candidate new drug for anti-colorectal cancer.

Abstract: A CyclotheonellazoleA, a synthesis method therefor, and an application method thereof are provided, and a compound with a structure of formula (I) and a pharmaceutically acceptable salt thereof are provided, the structure of formula (I) is as follows: R1, R2, R3 and R4 are independently selected form the group consisting of a hydrogen group (H), an alkyl group with carbon atoms in a range of 1-6, an alkoxy group with carbon atoms in a range of 1-6, a halogen group, a hydroxyl group, an amino group, a nitro group, a cyano group and a sulfydryl group. A CyclotheonellazoleA natural product is successfully synthesized by a classical retrosynthesis analysis, a stereoscopic structure of the CyclotheonellazoleA natural product is confirmed, extremely excellent protease inhibitory activity of the CyclotheonellazoleA natural product is confirmed by combining a protease inhibition activity experiment, and the CyclotheonellazoleA has a strong application prospect in a pharmaceutical industry.

Abstract: A structural analog of Cyclotheonellazole A, and a synthetic method therefor and an application method thereof are provided. A compound with a structure of formula (I) and a pharmaceutically acceptable salt thereof are provided. The formula (I) is as follows: R1, R2, R3 and R4 are independently selected form the group consisting of H, a C1-C6 alkyl group, a C1-C6 alkoxy group, a halogen group, a hydroxyl group, an amino group, a nitro group, a cyano group, and a sulfydryl group. Based on the total synthetic route of Cyclotheonellazole A, the classical reverse synthesis analysis is utilized, the structural modification is purposefully carried out, a mother nucleus of the natural product remains unchanged, and the structural analog 1a is obtained by replacing a left side chain with a simple formylamine, thereby confirming the excellent protease inhibitory activity thereof, and having a strong application prospect in the pharmaceutical industry.

Abstract: A high-precision positioning method and system for a high-speed train is provided, which belongs to the technical field of high-speed train positioning. A multi-objective optimization model is first established. An objective function is a function obtained by weighing a positioning error function of the BeiDou satellite navigation system, a distance error function and a direction error function of the inertial navigation system. Constraint conditions include a positioning error constraint of the BeiDou satellite navigation system, a distance error constraint and a direction error constraint of the inertial navigation system, and a positioning error constraint of an electronic map. The multi-objective optimization model is solved with first positioning data of the BeiDou satellite navigation system and second positioning data of the inertial navigation system as inputs thereof by using an improved differential evolution algorithm, to obtain optimal positioning data of the high-speed train.

Abstract: A benzo[b]selenophene STING regulator, a preparation method therefore and use thereof are disclosed. The structure of the compound is shown in Formula I. A derivative, salt, stereoisomer, prodrug molecule and pharmaceutical composition of the present invention can serve as an immune regulator to effectively activate an innate immune regulation passageway to kill tumor cells.

Abstract: A preparation method of a novel natural bioactive peptide Tubulysin U includes: dissolving a compound 2 in trifluoroacetic acid, heating under reflux to prepare an intermediate, reacting with a compound 3 and N,N-diisopropylethylamine to obtain a product, reacting the product with 2, 6-dimethylpyridine and tert-butyldimethylsilyl trifluoromethanesulfonate, adding sodium hydroxide after the reaction to prepare an intermediate acid, reacting the intermediate acid with a compound 6, HATU and N,N-diisopropylethylamine to obtain a product, adding triphenylphosphine to prepare an intermediate amine, adding a compound 8 and HATU to react, adding ammonium fluoride to prepare a first intermediate, adding sodium hydroxide to the first intermediate to prepare a second intermediate, adding acetic anhydride to the second intermediate to prepare a third intermediate, adding trifluoroacetic acid to the third intermediate to prepare a fourth intermediate, and adding formaldehyde and sodium cyanoborohydride to the fourth inte

Abstract: A preparation method of a novel natural bioactive peptide Tubulysin U includes: dissolving a compound 2 in trifluoroacetic acid, heating under reflux to prepare an intermediate, reacting with a compound 3 and N,N-diisopropylethylamine to obtain a product, reacting the product with 2, 6-dimethylpyridine and tert-butyldimethylsilyl trifluoromethanesulfonate, adding sodium hydroxide after the reaction to prepare an intermediate acid, reacting the intermediate acid with a compound 6, HATU and N,N-diisopropylethylamine to obtain a product, adding triphenylphosphine to prepare an intermediate amine, adding a compound 8 and HATU to react, adding ammonium fluoride to prepare a first intermediate, adding sodium hydroxide to the first intermediate to prepare a second intermediate, adding acetic anhydride to the second intermediate to prepare a third intermediate, adding trifluoroacetic acid to the third intermediate to prepare a fourth intermediate, and adding formaldehyde and sodium cyanoborohydride to the fourth inte

Abstract: The present invention relates to the discovery of small molecule compounds that act as GLP-1R agonists and/or as positive allosteric modulators (PAMs) of GLP-1R. Such compounds are useful to treat, ameliorate, and/or prevent insulin resistance and/or diabetes in a mammal.

Abstract: A bicycle repair system comprises an intelligent bicycle locking device, an intelligent toolbox, and a central processing unit. The intelligent bicycle locking device is connected to the central processing unit, and the intelligent toolbox is connected to the central processing unit. The intelligent bicycle locking device is configured to send an obtained first user information to the central processing unit. The intelligent toolbox is configured to send an obtained second user information to the central processing unit. The central processing unit is configured to determine whether the second user information is the same as the first user information and, if yes, send an opening instruction to the intelligent toolbox sending the second user information, so as to help a user to repair a damaged bicycle by using the intelligent toolbox, so that the bicycle can be repaired without depending on a repair person, thereby improving the repair efficiency.

Abstract: A steel girder pavement structure (100) for high-speed road for bicycle, and a roadbed pavement method therefor. The pavement structure (100) includes a top plate (10), a bottom plate (20), a web (30), stiffening plates (40), and decorative plates (50). A composite roadbed is paved on a surface layer of the top plate (10). The composite roadbed includes, from bottom to top, a substrate, a primer coating and quartz sand (101), a waterproof coating (102), an anti-slip coating and quartz sand (103), a wear-resistant coating (104) and an anti-ultraviolet coating (105). The roadbed pavement method includes: paving various layers of materials on a surface of the steel plate from bottom to top. The high-speed road for bicycle is easy to seamlessly connect to a transportation hub, and has a high comfort degree.

Abstract: Disclosed are a steel girder pavement structure (100) for high-speed road for bicycle, and a roadbed pavement method therefor. The pavement structure (100) includes a top plate (10), a bottom plate (20), a web (30), stiffening plates (40), and decorative plates (50). A composite roadbed is paved on a surface layer of the top plate (10). The composite roadbed includes, from bottom to top, a substrate, a primer coating and quartz sand (101), a waterproof coating (102), an anti-slip coating and quartz sand (103), a wear-resistant coating (104) and an anti-ultraviolet coating (105). The roadbed pavement method includes: paving various layers of materials on a surface of the steel plate from bottom to top. The high-speed road for bicycle is easy to seamlessly connect to a transportation hub, and has a high comfort degree.

Abstract: The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide.

Abstract: A bicycle repair system comprises an intelligent bicycle locking device, an intelligent toolbox, and a central processing unit. The intelligent bicycle locking device is connected to the central processing unit, and the intelligent toolbox is connected to the central processing unit. The intelligent bicycle locking device is configured to send an obtained first user information to the central processing unit. The intelligent toolbox is configured to send an obtained second user information to the central processing unit. The central processing unit is configured to determine whether the second user information is the same as the first user information and, if yes, send an opening instruction to the intelligent toolbox sending the second user information, so as to help a user to repair a damaged bicycle by using the intelligent toolbox, so that the bicycle can be repaired without depending on a repair person, thereby improving the repair efficiency.