Abstract: A high-efficiency yield-increasing exploitation method for natural gas hydrates includes steps of drilling of natural gas hydrate reservoirs along horizontal wells, seepage increasing by fracturing for fracture forming and stability improvement by grouting in the natural gas hydrate reservoirs, and yield improvement by combined exploitation of depressurization of the horizontal wells and heat injection; according to the present invention, drilling time is shortened by rapid drilling along the horizontal wells, the permeability of the reservoirs can be effectively improved by fracturing for fracture forming, the stability of the reservoirs can be improved by injecting foam cement slurry into the reservoirs, and the yield of the natural gas hydrates can be improved by the combined exploitation method of depressurization of the horizontal wells and heat injection.

Abstract: The present disclosed a preparation method preparation method for, and use of, a small molecular drug-loaded polymer vesicle. The small molecular drug-loaded polymer vesicle is prepared by assembling an amphiphilic block polymer and a small molecular drug; or is obtained by assembling and cross-linking the amphiphilic block polymer and a functionalized amphiphilic block polymer, loading the small molecular drug, and then reacting with a targeting monoclonal antibody. The vesicle system has many unique advantages, including small size, simple and controllable preparation, excellent biocompatibility, high stability of circulation in vivo, strong specific selectivity of tumor cells, high intracellular drug release rate, remarkable effect of tumor growth inhibition, etc. Therefore, the vesicle system is expected to become a simple and multi-functional nano-platform for efficient and specific targeted delivery of vincristine sulfate to multiple myeloma cells.

Abstract: A high-efficiency yield-increasing exploitation method for natural gas hydrates includes steps of drilling of natural gas hydrate reservoirs along horizontal wells, seepage increasing by fracturing for fracture forming and stability improvement by grouting in the natural gas hydrate reservoirs, and yield improvement by combined exploitation of depressurization of the horizontal wells and heat injection; according to the present invention, drilling time is shortened by rapid drilling along the horizontal wells, the permeability of the reservoirs can be effectively improved by fracturing for fracture forming, the stability of the reservoirs can be improved by injecting by the combined exploitation method of depressurization of the horizontal wells and heat injection.

Abstract: A method for controlling image capture includes: receiving, from a movable device, an image of a target imaging area; adjusting, by a first control apparatus, one or more first imaging parameters for imaging the target imaging area based at least in part on the image to obtain one or more first adjusted imaging parameters; adjusting, by operating on an interactive interface of a second control apparatus, one or more second imaging parameters for imaging the target imaging area based at least in part on the image to obtain one or more second adjusted imaging parameters, the interactive interface being configured to receive user interaction to control an attitude of a gimbal device configured on the movable device, the gimbal device carrying an imaging device for imaging the targeted area; and sending, by the first control apparatus and/or the second control apparatus, an instruction carrying the one or more first adjusted imaging parameters and the one or more second adjusted imaging parameters to the movable

Abstract: A drug-loaded polymer vesicle having an asymmetric membrane structure, a preparation method therefor, and an application thereof in preparation of drugs for treating acute myeloid leukemia. An amphiphilic triblock polymer having polyaspartic acid (PAsp), a targeted amphiphilic block polymer, and a small-molecule drug are assembled together to prepare the targeted small-molecule drug-loaded polymer vesicle having the asymmetric membrane structure. The drug-loaded polymer vesicle has many unique advantages, comprising small size, simple and controllable preparation, reversible crosslinking, in-vivo stability, targeted delivery, high enrichment concentration of intracellular drugs, reduction sensitivity, efficient killing of tumor cells, remarkable tumor growth inhibition effect, etc., and has an effective inhibition effect on both acute myelogenous leukemia cell strains and patient cells.

Abstract: An anti-tumor nano adjuvant is obtained by loading a drug on the vesicle formed by a reversibly cross-linked biodegradable polymer with an asymmetric membrane structure; the drug is an oligonucleotide activating an immune response; the vesicle formed by the degradable polymer is obtained by the self-assembly of a polymer followed by cross-linking; the molecular chain of the polymer includes a hydrophilic chain segment, a hydrophobic chain segment and positively charged molecules, successively connected; the hydrophobic chain segment is a polycarbonate chain segment and/or a polyester chain segment, which is compounded and loaded with a drug by electrostatic interaction; and the membrane is a polycarbonate chain segment and/or a polyester chain segment, which is reversibly cross-linked, biodegradable and has good biocompatibility, the dithiolane in the side chain thereof is similar to thioctic acid, a natural antioxidant in human body, and the shell thereof is based on PEG and targets cancer cells.

Abstract: Provided are an energy storage power supply, a parallel control device for energy storage power supplies and a parallel control method for energy storage power supplies. The energy storage power supply includes a battery module; an inverter module electrically connected to the battery module; an output module electrically connected to the inverter module; an detection module electrically connected to the output module; an communication module communicated with another energy storage power supply; an switching module electrically connected to the inverter module or the output module; and a processor module electrically connected to the detection module, the communication module and the switching module, and is configured to control, according to the power of a load detected by the detection module, the switching module to be electrically connected to the inverter module or the output module.

Abstract: Provided are an energy storage power supply, a parallel control device for energy storage power supplies and a parallel control method for energy storage power supplies. The energy storage power supply includes a battery module; an inverter module electrically connected to the battery module; an output module electrically connected to the inverter module; an detection module electrically connected to the output module; an communication module communicated with another energy storage power supply; an switching module electrically connected to the inverter module or the output module; and a processor module electrically connected to the detection module, the communication module and the switching module, and is configured to control, according to the power of a load detected by the detection module, the switching module to be electrically connected to the inverter module or the output module.

Abstract: A method for determining an estimated time of arrival (ETA) includes receiving a start location and a destination from a user device via a network. The method also includes obtaining a machine learning model for determining an ETA, which is generated according to a process including: obtaining historical data related to an on-demand service order; determining a high-dimensional sparse feature based on the historical data; and determining a machine learning model based on the high-dimensional sparse feature. The method further includes determining an ETA for a target route based on the machine learning model, the start location, and the destination, and transmitting the determined ETA to the user device via the network.

Abstract: A method of controlling power supply of a caravan including a photovoltaic plate includes: receiving a first power parameter of an input interface element; determining whether there is a mains supply to be input into the input interface element according to the first power parameter; turning on a first switch to make the input interface element be electrically connected to the output interface element if the mains supply is input into the input interface element; receiving a power parameter of a battery pack if the mains supply is not input into the input interface element; determining whether a remaining power of the battery pack exceeds a power threshold according to the power parameter of the battery pack; and making the battery pack be electrically connected to an output interface element if the remaining power of the battery pack exceeds the power threshold.

Abstract: A method of controlling power supply of a caravan including a photovoltaic plate includes: receiving a first power parameter of an input interface element; determining whether there is a mains supply to be input into the input interface element according to the first power parameter; turning on a first switch to make the input interface element be electrically connected to the output interface element if the mains supply is input into the input interface element; receiving a power parameter of a battery pack if the mains supply is not input into the input interface element; determining whether a remaining power of the battery pack exceeds a power threshold according to the power parameter of the battery pack; and making the battery pack be electrically connected to an output interface element if the remaining power of the battery pack exceeds the power threshold.

Abstract: Disclosed in the present disclosure is a biodegradable amphiphilic polymer containing disulfide in the side chain, a self-crosslinked polymeric vesicle thereof and an application in the targeted therapy of lung cancer. The polymer is obtained by an activity-controllable ring-opening polymerization based on a cyclic carbonate monomer containing a functional group of dithiolane ring, which has a controllable molecular weight and a narrow molecular weight distribution, and does not require processes of protection and deprotection; the polymer obtained by the ring-opening polymerization of the cyclic carbonate monomer of the present disclosure has biodegradability and can be used to control the drug release system, the prepared lung cancer-targeted reduction-sensitive reversibly-crosslinked polymeric vesicle as a nanomedicine carrier supports stable long circulation in vivo.

Abstract: A method for determining an estimated time of arrival (ETA) includes receiving a start location and a destination from a user device via a network. The method also includes obtaining a machine learning model for determining an ETA, which is generated according to a process including: obtaining historical data related to an on-demand service order; determining a high-dimensional sparse feature based on the historical data; and determining a machine learning model based on the high-dimensional sparse feature. The method further includes determining an ETA for a target route based on the machine learning model, the start location, and the destination, and transmitting the determined ETA to the user device via the network.

Abstract: Disclosed in the present disclosure is a biodegradable amphiphilic polymer containing disulfide in the side chain, a self-crosslinked polymeric vesicle thereof and an application in the targeted therapy of lung cancer. The polymer is obtained by an activity-controllable ring-opening polymerization based on a cyclic carbonate monomer containing a functional group of dithiolane ring, which has a controllable molecular weight and a narrow molecular weight distribution, and does not require processes of protection and deprotection; the polymer obtained by the ring-opening polymerization of the cyclic carbonate monomer of the present disclosure has biodegradability and can be used to control the drug release system, the prepared lung cancer-targeted reduction-sensitive reversibly-crosslinked polymeric vesicle as a nanomedicine carrier supports stable long circulation in vivo.

Abstract: The disclosure relates to a cyclic carbonate monomer containing double iodine, a biodegradable polymer prepared thereby and use. The polymer can be obtained by ring-opening polymerization of the cyclic carbonate monomer containing double iodine, without affecting the ring-opening polymerization and without a protection and deprotection process. The polymer which is obtained by ring-opening polymerization of the cyclic carbonate monomer of the present disclosure can be assembled into a nano-vesicle and a micelle as a drug carrier, a biological tissue scaffold or a CT contrast media.

Abstract: Disclosed are a hyaluronic acid-based amphiphilic polymer, preparation method and application thereof. A main chain of the amphiphilic polymer is a hydrophilic hyaluronic acid and can be employed in active targeting, and a side chain thereof is a hydrophobic group represented by Formula (1). The amphiphilic polymer can carry a small molecule anticancer drug. Polymer nanoparticles are obtained via chemical crosslinking, such that the nanoparticles are not readily dissociated outside a cell or in blood, thus ensuring the stability of a drug encapsulated by the nanoparticles. Upon arriving at a tumor tissue, the hyaluronic acid on a surface of the nanoparticle can immediately combine with a CD44 receptor on a surface of a tumor cell, and effectively enter the tumor cell via endocytosis mediated by the receptor, and then quickly de-crosslink to be dissociated.

Abstract: The present invention relates to biodegradable polyesteramides (PEAs) comprising hydrophobic alpha-amino acids, diols, aliphatic dicarboxylic acids and optionally diamines whereby at least one of the dicarboxylic acids, diols or diamines comprises disulphide linkages. The present invention also relates to the use of the polyesteramides in medical applications such as cancer treatment, ophthalmic applications, therapeutic cardiovascular applications, veterinary applications, pain management applications, MSK applications and vaccine delivery compositions. The present invention also relates to a drug delivery composition comprising the PEA's and to a drug delivery system such as micro- or nanoparticles, micelles, liposomes, polymerosomes, micro- and nanogels, polymerosomes or nanotubes.

Abstract: Provided are an ovarian cancer specifically targeted biodegradable amphiphilic polymer, a polymer vesicle prepared thereby and use thereof. The biodegradable amphiphilic polymer is prepared by a polymer containing dithiocarbonate monomer bonded with targeting molecules. The polymer vesicle prepared with the biodegradable amphiphilic polymer can crosslink spontaneously without adding an extra crosslinker, and the crosslink has a reduction activity and hence can be used in drug controlled-release systems, and contributes to the clinical use and production of nano-drugs.

Abstract: Apparatus relates to a carbonate polymer containing a functional group of disulfide five-membered ring in the side chain and application thereof. The polymer can be prepared from cyclic carbonate monomer containing a disulfide five-membered ring functional group through the activity controllable ring-opening polymerization. For polymer, molecular weight is controlled, molecular weight distribution is narrowed and does not require the protection and deprotection procedures. Polymer prepared from the carbonate monomer through the ring-opening polymerization has biodegradability, can be used for controlling drugs release system, and can be used to prepare tumor-targeted nano-drug carrier which is sensitive to reduction and is reversible cross-linking, can support long circulation in the body, in high concentration of cancers cells can rapidly release cross-linking in the cancer cells, to release drugs, to kill cancer cells with high efficiency and specificity.