Patents by Inventor Zhong Ding

Zhong Ding has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230022609
    Abstract: A method of preparing a Polygoni Milletii Rhizome tincture includes: preparing a first mixture; extracting the first mixture with 70-90% ethanol under reflux condition to obtain a first extract solution; preparing a second mixture; extracting the second mixture with 50-70% ethanol to obtain a second extract solution; and mixing the first extract solution with the second extract solution to obtain the polygoni milletii rhizome tincture. A method of preparing a Polygoni Milletii Rhizome poultice includes: reparing a Polygoni Milletii Rhizome mixture; mixing the Polygoni Milletii Rhizome mixture and a skin penetration enhancer in water; mixing a moisturizing agent and a binder in water; adding a thickener in water; mixing methylparaben and ethylparaben in 90% ethanol; mixing all solutions to form a mixture; and applying the mixture on a non-woven fabric cloth and drying to form the Polygoni Milletii Rhizome poultice.
    Type: Application
    Filed: July 1, 2022
    Publication date: January 26, 2023
    Inventors: Xiaolin XIE, Dezhu ZHANG, Chengyuan LIANG, Shujun DING, Yuzhi LIU, Zhao MA, Xuhua ZHOU, Zhong MENG, Jianguo MENG
  • Patent number: 11501083
    Abstract: Techniques are provided for training, by a system operatively coupled to a processor, an attention weighted recurrent neural network encoder-decoder (AWRNNED) using an iterative process based on one or more paragraphs of agent sentences from respective transcripts of one or more conversations between one or more agents and one or more customers, and based on one or more customer response sentences from the respective transcripts, and generating, by the system, one or more groups respectively comprising one or more agent sentences and one or more customer response sentences selected based on attention weights of the AWRNNED.
    Type: Grant
    Filed: December 24, 2020
    Date of Patent: November 15, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Ke Ke Cai, Jing Ding, Zhong Su, Chang Hua Sun, Li Zhang, Shi Wan Zhao
  • Patent number: 11494936
    Abstract: The present disclosure is directed to a method and apparatus for locating a target location on a reaction cell and using the target location to perform an assay. In an example embodiment, a method of performing at least one assay includes obtaining at least one image of a fluid sample located on a reaction cell and creating a set of derivative data including a plurality of derivative data points based on the at least one image. The method also includes determining an image gradient data point for each of the plurality of derivative data points and determining a target location of the fluid sample in the reaction cell based on the image gradient data points. The method further includes performing at least one assay using the target location of the fluid sample in the reaction cell.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: November 8, 2022
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Johanna Julia-Trecaso Miller, Theodore J. DiMagno
  • Patent number: 11447165
    Abstract: A train window structure and a train with the train window structure, the train window structure comprises a train window frame; train window glass arranged on the train window frame and internally provided with a hollow structure; and a display arranged in the hollow structure to display information on the train window glass, and information is displayed on the display in the hollow structure and is provided for passengers.
    Type: Grant
    Filed: September 30, 2017
    Date of Patent: September 20, 2022
    Assignee: CRRC QINGDAO SIFANG CO., LTD.
    Inventors: Sansan Ding, Yali Jia, Kainan Mao, Peng Gao, Shanshan Wang, Yu Zeng, Zhong Li, Yuwen Liu, Zhenzhong Wang
  • Publication number: 20220219162
    Abstract: A lateral-flow assay device includes a substrate having a sample addition zone and a wash addition zone downstream thereof along a fluid flow path through which a sample flows. The fluid flow path is configured to receive a wash fluid in the wash addition zone. A hydrophilic surface is arranged in the wash addition zone. Flow constriction(s) are spaced apart from the fluid flow path and arranged to define, with the hydrophilic surface, a reservoir configured to retain the wash fluid by formation of a meniscus between the hydrophilic surface and the flow constriction(s). The fluid flow path draws the wash fluid from the reservoir by capillary pressure. Apparatus for analyzing a fluidic sample and methods of displacing a fluidic sample in a fluid flow path of an assay device are also described.
    Type: Application
    Filed: January 18, 2022
    Publication date: July 14, 2022
    Inventors: Zhong DING, Edward R. SCALICE, Daniel P. SALOTTO
  • Patent number: 11293879
    Abstract: The present disclosure is directed to a method and apparatus for performing an assay on a dry slide or other solid media using a reduced reading window. In an embodiment, method of performing at least one assay comprises obtaining an image of a fluid sample located on a dry slide, positioning a reading window to correspond to an area of the fluid sample in the image, determining an interference area within the reading window based on light intensity, reducing the reading window to eliminate the interference area from the reading window, and performing at least one assay using the reduced reading window.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: April 5, 2022
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Andrew M. Kirsch, Edward R. Scalice, Benjamin Wojtasiewicz
  • Patent number: 11287424
    Abstract: A method for performing an assay on a liquid sample for the detection of one or more analytes of interest in an assay device having a flow path which includes a sample zone and detection zone thereon includes: dispensing the sample onto the sample zone; combining the sample and a reagent, wherein the sample and reagent may be combined prior to addition of the sample to the sample zone or on the assay device, flowing the combined sample/reagent by capillary action into and through the detection zone having capture elements bound thereto, wherein a signal at least partially representative of the presence or concentration of analyte(s) is produced and detected; determining a reaction time or reaction volume; and determining the concentration of the analyte by using both the detected signal and the reaction time or reaction volume.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: March 29, 2022
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Edward R. Scalice
  • Patent number: 11260390
    Abstract: A lateral-flow assay device includes a substrate having a sample addition zone and a wash addition zone downstream thereof along a fluid flow path through which a sample flows. The fluid flow path is configured to receive a wash fluid in the wash addition zone. A hydrophilic surface is arranged in the wash addition zone. Flow constriction(s) are spaced apart from the fluid flow path and arranged to define, with the hydrophilic surface, a reservoir configured to retain the wash fluid by formation of a meniscus between the hydrophilic surface and the flow constriction(s). The fluid flow path draws the wash fluid from the reservoir by capillary pressure. Apparatus for analyzing a fluidic sample and methods of displacing a fluidic sample in a fluid flow path of an assay device are also described.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: March 1, 2022
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Edward R. Scalice, Daniel P. Salotto
  • Publication number: 20210268496
    Abstract: Described herein are clinical diagnostics and more specifically to a lateral-flow assay devices.
    Type: Application
    Filed: May 12, 2021
    Publication date: September 2, 2021
    Inventors: Zhong Ding, Edward R. Scalice, Philip C. Hosimer
  • Publication number: 20210263020
    Abstract: Disclosed is method of improving flow of a liquid sample in an assay device, as well as a method of performing an assay on a liquid sample for the detection of one or more analytes of interest. The methods use the addition of a reagent, such as a wash reagent, to wet the fluid flow path of a sample prior to sample addition, thereby improving flow of the sample through the fluid flow path that has been wetted as opposed to flow of the sample through the fluid flow path that has not been wetted. The reagent wets the fluid flow path between the sample addition zone and the wicking zone.
    Type: Application
    Filed: May 10, 2021
    Publication date: August 26, 2021
    Inventors: Zhong Ding, Philip C. Hosimer, Edward Scalice
  • Patent number: 11033896
    Abstract: A lateral-flow assay device includes a substrate with a sample addition zone and a fluid flow path. A cover supports a filter having a portion contacting the substrate to create a contact area that at least partly overlaps the sample addition zone. Another portion extends from the contact portion to the supported periphery of the filter to define with the substrate a reservoir configured to retain the filtrate by capillary pressure between the substrate and the extending portion. The reservoir volume is based on an acute angle formed between the substrate and the extending portion of the filter and on a fluid meniscus of the filtrate. The filter and sample addition zone are configured to provide capillary pressure drawing the filtrate from the reservoir to the sample addition zone. Methods for controlling flow characteristics in a lateral-flow assay device are also described.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: June 15, 2021
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Edward R. Scalice, Philip C. Hosimer
  • Patent number: 11026611
    Abstract: A sample collection device for a fluid includes: a substantially disk-shaped body having a periphery; a capillary channel extending through the body and bounded by the periphery, having a first end and a second end, wherein the first end is adapted to draw the fluid into the channel by capillary action; a sample collection well located in the vicinity of the second end and in fluid communication with the capillary channel; and an axis of rotation extending through the center of the disk and which is substantially perpendicular to the major surface of the disk-shaped body. In a preferred embodiment, the sample collection device is adapted to rotate about the axis of rotation within a cartridge having a housing comprising an air vent in fluid communication with the capillary channel when the disk is rotated in a first position.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: June 8, 2021
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Kory A. Gunnerson, Raymond F. Jakubowicz, Andrew M. Kirsch, James Ellis Robinson, Daniel P. Salotto, David A. Tomasso, Zhong Ding, William Franklin Gottermeier, Aaron Michael Swick
  • Patent number: 11002732
    Abstract: Disclosed is method of improving flow of a liquid sample in an assay device, as well as a method of performing an assay on a liquid sample for the detection of one or more analytes of interest. The methods use the addition of a reagent, such as a wash reagent, to wet the fluid flow path of a sample prior to sample addition, thereby improving flow of the sample through the fluid flow path that has been wetted as opposed to flow of the sample through the fluid flow path that has not been wetted. The reagent wets the fluid flow path between the sample addition zone and the wicking zone.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: May 11, 2021
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Zhong Ding, Philip C. Hosimer, Edward Scalice
  • Publication number: 20210055284
    Abstract: A lateral flow (immunoassay) device retains at least one assay chip inside a solid frame. Each assay chip includes a sample zone, a conjugate zone, capture zone(s) and a waste zone. The sample and waste zones each include a hydrophilic pad sitting above the chip. The frame is hydrophobic, having a fluid metering window and optional air vent in the top and a scan window provided at the bottom. A sample with analyte is dispensed with the volume of sample such that fluid flow stops when solution with dissolved conjugate reaches a designated location in the chip, and at least a portion of the waste zone is still dry. A second fluid is subsequently added to wash off unbound conjugate in the capture zone after the device with first fluid has been incubated for an assay specified time period. During incubation and after wash, multiple optical scans are performed to obtain conjugate signal profiles along the chip. The features of the signal are used to define an assay signal read location.
    Type: Application
    Filed: August 19, 2020
    Publication date: February 25, 2021
    Inventor: Zhong Ding
  • Publication number: 20200300841
    Abstract: Disclosed is an assay device which comprises a liquid sample addition zone, a reagent zone, a detection zone, and a wicking zone, all defining a fluid flow path. The device further comprises a reagent addition zone along and in fluid communication with the fluid flow path downstream of the sample addition zone and upstream of the detection zone. An interrupting wash is added at this reagent addition zone in accordance with the method of the subject invention to control sample volume. The interrupting wash fluid is added at a predetermined fill volume on the chip device and also serves to wash the detection channel and fill the remaining chip volume.
    Type: Application
    Filed: June 8, 2020
    Publication date: September 24, 2020
    Inventors: Edward R. Scalice, Philip C. Hosimer, Zhong Ding, James D. Kanaley, David A. Tomasso, Daniel P. Salotto, Timothy C. Warren
  • Patent number: 10712340
    Abstract: Disclosed is an assay device which comprises a liquid sample addition zone, a reagent zone, a detection zone, and a wicking zone, all defining a fluid flow path. The device further comprises a reagent addition zone along and in fluid communication with the fluid flow path downstream of the sample addition zone and upstream of the detection zone. An interrupting wash is added at this reagent addition zone in accordance with the method of the subject invention to control sample volume. The interrupting wash fluid is added at a predetermined fill volume on the chip device and also serves to wash the detection channel and fill the remaining chip volume.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: July 14, 2020
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Edward R. Scalice, Philip C. Hosimer, Zhong Ding, James D. Kanaley, David A. Tomasso, Daniel P. Salotto, Timothy C. Warren
  • Publication number: 20200003699
    Abstract: The present disclosure is directed to a method and apparatus for performing an assay on a dry slide or other solid media using a reduced reading window. In an embodiment, method of performing at least one assay comprises obtaining an image of a fluid sample located on a dry slide, positioning a reading window to correspond to an area of the fluid sample in the image, determining an interference area within the reading window based on light intensity, reducing the reading window to eliminate the interference area from the reading window, and performing at least one assay using the reduced reading window.
    Type: Application
    Filed: July 1, 2019
    Publication date: January 2, 2020
    Inventors: Zhong Ding, Andrew M. Kirsch, Edward R. Scalice, Benjamin Wojtasiewicz
  • Publication number: 20200005488
    Abstract: The present disclosure is directed to a method and apparatus for locating a target location on a reaction cell and using the target location to perform an assay. In an example embodiment, a method of performing at least one assay includes obtaining at least one image of a fluid sample located on a reaction cell and creating a set of derivative data including a plurality of derivative data points based on the at least one image. The method also includes determining an image gradient data point for each of the plurality of derivative data points and determining a target location of the fluid sample in the reaction cell based on the image gradient data points. The method further includes performing at least one assay using the target location of the fluid sample in the reaction cell.
    Type: Application
    Filed: June 27, 2019
    Publication date: January 2, 2020
    Inventors: Zhong Ding, Johanna Julia-Trecaso Miller, Theodore J. DiMagno
  • Patent number: 10509031
    Abstract: A method for providing quality control on a lateral flow assay device or for triggering a process-related step, the device including a substrate having at least one sample receiving area, at least one reagent zone downstream and in fluid communication with the at least one sample receiving area, at least one detection zone downstream and in fluid communication with the at least one reagent zone and at least one wicking zone downstream of the at least one detection zone, each fluidly interconnected therewith along at least one fluid flow path. The detection material provided in the at least one reagent zone produces a detectable signal that can be tracked and monitored prior to the completion of at least one test being performed on the lateral flow assay device.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: December 17, 2019
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Zhong Ding, James E. Robinson, David A. Tomasso, David A. Heavner
  • Publication number: 20180345277
    Abstract: A lateral-flow assay device includes a substrate having a sample addition zone and a wash addition zone downstream thereof along a fluid flow path through which a sample flows. The fluid flow path is configured to receive a wash fluid in the wash addition zone. A hydrophilic surface is arranged in the wash addition zone. Flow constriction(s) are spaced apart from the fluid flow path and arranged to define, with the hydrophilic surface, a reservoir configured to retain the wash fluid by formation of a meniscus between the hydrophilic surface and the flow constriction(s). The fluid flow path draws the wash fluid from the reservoir by capillary pressure. Apparatus for analyzing a fluidic sample and methods of displacing a fluidic sample in a fluid flow path of an assay device are also described.
    Type: Application
    Filed: August 3, 2018
    Publication date: December 6, 2018
    Inventors: Zhong Ding, Edward R. Scalice, Daniel P. Salotto