Abstract: A method and a system for registering real-time intra-operative image data of a body to a model of the body, the method comprising, segmenting a plurality of image data of the body obtained using a pre-operative imaging device; constructing the model of the body from the segmented plurality of image data; identifying one or more landmark features on the model of the body; acquiring the real-time intra-operative image data of the body using an intra-operative imaging device; and registering the real-time intra-operative image data of the body to the model of the body by matching one or more landmark features labelled on the real-time intra-operative image data to one or more corresponding landmark features on the model of the body, wherein the one or more landmark features comprises a superior and an inferior pole of the body.