Patents by Inventor Zhonghui Hugh Fan
Zhonghui Hugh Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11845997Abstract: Described herein are bioaerosol detection systems and methods of use. In embodiments of bioaerosol detection systems and methods of use as described herein, systems and methods detect one or more coronaviruses and/or one or more influenza strains. In embodiments, coronaviruses according to systems and methods as described herein are SARS-CoV-2 coronavirus. In embodiments, influenza strains and/or particles according to the present disclosure are H1N1 influenza.Type: GrantFiled: November 25, 2020Date of Patent: December 19, 2023Assignee: University of Florida Research Foundation, Inc.Inventors: Chang-Yu Wu, Xiao Jiang, Maohua Pan, John Lednicky, Alexandros Demetrios Theodore, Zhonghui Hugh Fan, Nima Afshar Mohajer
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Publication number: 20210236992Abstract: A lateral filter array microfluidic (LFAM) device for highly efficient immunoaffinity isolation of target cells from a population of cells. The LFAM device may include of one or more serpentine main channels incorporated with lateral filter arrays. Antibodies are immobilized on the channel surface including the lateral filters and are capable of specific binding to one or more biomolecules on the surface of the target cell. The device may include one or more arrays of lateral filters with different sizes. The overall filters sizes are close to the diameter of the target cell, therefore the interaction between biomarkers on the target cells and corresponding antibodies immobilized on the filter surface is largely strengthened due to the direct contact between target cells and lateral filters. Methods include flowing a population of cells through an antibody-coated LFAM device for target cells capture, followed by washing the device to remove non-specific captured cells.Type: ApplicationFiled: August 21, 2019Publication date: August 5, 2021Inventors: Zhonghui Hugh FAN, Kangfu CHEN
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Publication number: 20210230533Abstract: An apparatus and method are provided for performing detection of microorganisms (e.g., viruses) with high sensitivity. The apparatus and method are well suited for point-of-care (POC) testing in resource-limited regions and are capable of being operated with very little manual intervention and without the need for lab equipment. A variety of viruses can be detected with high sensitivity, including, for example, coronaviruses, Zika virus and flu viruses.Type: ApplicationFiled: January 4, 2021Publication date: July 29, 2021Inventors: Zhonghui Hugh Fan, Xiao Jiang, Trevor B. Tilly, John Lednicky, Chang-Yu Wu
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Publication number: 20210102265Abstract: Described herein are bioaerosol detection systems and methods of use. In embodiments of bioaerosol detection systems and methods of use as described herein, systems and methods detect one or more coronaviruses and/or one or more influenza strains. In embodiments, coronaviruses according to systems and methods as described herein are SARS-CoV-2 coronavirus. In embodiments, influenza strains and/or particles according to the present disclosure are H1N1 influenza.Type: ApplicationFiled: November 25, 2020Publication date: April 8, 2021Inventors: Chang-Yu WU, Xiao JIANG, Maohua PAN, John LEDNICKY, Alexandros Demetrios THEODORE, Zhonghui Hugh FAN, Nima AFSHAR MOHAJER
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Patent number: 10859473Abstract: Described herein are bioaerosol detection systems and methods of use.Type: GrantFiled: April 6, 2017Date of Patent: December 8, 2020Assignee: University of Florida Research Foundation, Inc.Inventors: Chang-Yu Wu, Xiao Jiang, Maohua Pan, John Lednicky, Alexandros Demetrios Theodore, Zhonghui Hugh Fan, Nima Afshar Mohajer
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Patent number: 10466243Abstract: The subject invention pertains to devices and methods of isolating target cells from a population of cells. The devices comprise of microfluidic channels and aptamers and antibodies attached to the inner surface of the microfluidic channels, wherein the aptamers and the antibodies are capable of specific binding to one or more biomolecules present on the surface of the target cell. The methods of the current invention comprise passing the population of cells through the microfluidic channels to facilitate interaction and capture of the target cells by the aptamers and the antibodies attached to the inner surface of the microfluidic channels, washing to microfluidic channels by a washing solution to remove the cells non-specifically bound to the aptamers and the antibodies attached to the inner surface of the microfluidic channels, releasing the captured target cells from the microfluidic channels, and collecting the released target cells.Type: GrantFiled: November 20, 2014Date of Patent: November 5, 2019Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATEDInventors: Zhonghui Hugh Fan, Jinling Zhang
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Publication number: 20190154550Abstract: Described herein are bioaerosol detection systems and methods of use.Type: ApplicationFiled: April 6, 2017Publication date: May 23, 2019Inventors: Chang-Yu WU, Xiao JIANG, Maohua PAN, John LEDNICKY, Alexandros Demetrios THEODORE, Zhonghui Hugh FAN, Nima AFSHAR MOHAJER
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Patent number: 10214713Abstract: The current is directed to a device comprising, a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes separating the reaction chamber from the one or more feeding chambers, and wherein the one or more porous membranes are in substantially vertical position. The current invention is also directed to an apparatus comprising a plurality of devices, wherein each device comprises of a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes which separate the reaction chamber from feeding chambers, wherein the one or more porous membranes are in substantially vertical position. These devices and apparatuses can be used for high throughput synthesis of biomolecules and chemicals and biological screening assays.Type: GrantFiled: July 17, 2014Date of Patent: February 26, 2019Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATEDInventors: Zhonghui Hugh Fan, Kirsten Marie Jackson
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Publication number: 20160291023Abstract: The subject invention pertains to devices and methods of isolating target cells from a population of cells. The devices comprise of microfluidic channels and aptamers and antibodies attached to the inner surface of the microfluidic channels, wherein the aptamers and the antibodies are capable of specific binding to one or more biomolecules present on the surface of the target cell. The methods of the current invention comprise passing the population of cells through the microfluidic channels to facilitate interaction and capture of the target cells by the aptamers and the antibodies attached to the inner surface of the microfluidic channels, washing to microfluidic channels by a washing solution to remove the cells non-specifically bound to the aptamers and the antibodies attached to the inner surface of the microfluidic channels, releasing the captured target cells from the microfluidic channels, and collecting the released target cells.Type: ApplicationFiled: November 20, 2014Publication date: October 6, 2016Inventors: ZHONGHUI HUGH FAN, JINLING ZHANG
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Publication number: 20160168526Abstract: The current is directed to a device comprising, a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes separating the reaction chamber from the one or more feeding chambers, and wherein the one or more porous membranes are in substantially vertical position. The current invention is also directed to an apparatus comprising a plurality of devices, wherein each device comprises of a reaction chamber where a reaction takes place, one or more feeding chambers which contain feeding solution comprising chemicals required for the reaction, and one or more porous membranes which separate the reaction chamber from feeding chambers, wherein the one or more porous membranes are in substantially vertical position. These devices and apparatuses can be used for high throughput synthesis of biomolecules and chemicals and biological screening assays.Type: ApplicationFiled: July 17, 2014Publication date: June 16, 2016Applicant: Universtiy of Florida Research Foundation, Inc.Inventors: Zhonghui Hugh Fan, Kirsten Marie Jackson
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Publication number: 20160091489Abstract: The subject invention pertains to devices and methods of isolating target cells from a population of cells. The devices comprise of one or more microfluidic channels and scaffolding particles conjugated with one or more ligands that bind to the target cells. The scaffolding particles with one or more ligands are attached on to the surface of the one or more microfluidic channels. The methods of the current invention comprise passing the population of cells through the microfluidic channels of the devices of the current invention to facilitate interaction and capture of the target cells by the scaffolding particles-ligand conjugates, washing the device by a washing solution to remove the cells non-specifically bound to the scaffolding particle-ligand conjugates, releasing the captured target cells from the scaffolding particle-ligand conjugates, and collecting the released target cells.Type: ApplicationFiled: June 3, 2014Publication date: March 31, 2016Inventors: ZHONGHUI HUGH FAN, WEIAN SHENG, TAO CHEN, WEIHONG TAN
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Publication number: 20030039868Abstract: Provided is a battery comprising a first compartment, a second compartment and a barrier separating the first and second compartments, wherein the barrier comprises a proton transporting moiety.Type: ApplicationFiled: August 23, 2002Publication date: February 27, 2003Inventors: Michael James Liberatore, Leszek Hozer, Attiganal Narayanaswamy Sreeram, Rajan Kumar, Chetna Bindra, Zhonghui Hugh Fan
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Patent number: 6500571Abstract: Provided is a fuel cell comprising a first compartment, a second compartment and a barrier separating the first and second compartments, wherein the barrier comprises a proton transporting moiety.Type: GrantFiled: August 18, 1999Date of Patent: December 31, 2002Assignee: PowerZyme, Inc.Inventors: Michael James Liberatore, Leszek Hozer, Attiganal Narayanaswamy Sreeram, Rajan Kumar, Chetna Bindra, Zhonghui Hugh Fan
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Publication number: 20020001739Abstract: Provided is a battery comprising a first compartment, a second compartment and a barrier separating the first and second compartments, wherein the barrier comprises a proton transporting moiety.Type: ApplicationFiled: August 18, 1999Publication date: January 3, 2002Inventors: MICHAEL JAMES LIBERATORE, LESZEK HOZER, ATTIGANAL NARAYANASWAMY SREERAM, RAJAN KUMAR, CHETNA BINDRA, ZHONGHUI HUGH FAN
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Patent number: 6296752Abstract: Provided is an apparatus for separating, in a medium, a component from a composition comprising: (1) an array of three or more electrodes arrayed along a pathway along which molecules of the composition are transported; and (2) a power source device for delivering to voltage to the electrodes; wherein the voltages delivered to the electrode array by the power source device are effective to: (a) alter the relative movement along the transport pathway of two or more of the molecules caused by a motive force, or (b) cause the molecules to move along the transport pathway.Type: GrantFiled: June 4, 1999Date of Patent: October 2, 2001Assignee: Sarnoff CorporationInventors: Sterling Eduard McBride, Satyam Choudary Cherukuri, Rajan Kumar, Judith Ann Ladd, Zhonghui Hugh Fan, Bryan Lloyd Bentz, Peter J. Zanzucchi
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Patent number: 5992820Abstract: Provided is a fluid control device comprising: (a) a channel of capillary dimensions for conveying a liquid, (b) a bubble-forming device for forming a channel-blocking bubble in the channel, wherein such a bubble formed in the channel impedes the flow of the liquid through the channel.Type: GrantFiled: November 19, 1997Date of Patent: November 30, 1999Assignee: Sarnoff CorporationInventors: Thomas Louis Fare, Zhonghui Hugh Fan, Paul James Heaney
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Patent number: 5846396Abstract: The present invention provides a liquid distribution system, which is useful in a number of contexts, including in accomplishing various synthetic, diagnostic and drug screening reactions. The distribution system can comprise an alpha reservoir and a beta reservoir, a first set of parallel and adjacent first and second feeder channels and a second set of parallel and adjacent third and fourth feeder channels which are offset from the first and second feeder channels, wherein (a) the first and third feeder channels are connected to the alpha reservoir via a first connector channel that is situated above or below the second and fourth feeder channels and are independent of the beta reservoir and (b) the second and fourth feeder channels are connected to the beta reservoir via a second connector channel that is situated above or below the first and third feeder channels and are independent of the alpha reservoir. The distribution system is preferably a microscale distribution system.Type: GrantFiled: November 9, 1995Date of Patent: December 8, 1998Assignee: Sarnoff CorporationInventors: Peter John Zanzucchi, Satyam Choudary Cherukuri, Sterling Edward McBride, Robert R. Demers, Aaron W. Levine, Barry Jay Thaler, Robert Leon Quinn, Paul Leonard Braun, William Chiang, Zhonghui Hugh Fan, Steven A. Lipp, James R. Matey