Abstract: The present invention provides a siRNA for inhibiting HTT gene expression and a precursor thereof, an expression vector comprising the siRNA or the precursor thereof, application thereof in preparation of a drug for treating Huntington's disease, and a pharmaceutical formulation and pharmaceutical composition containing the siRNA, the precursor or the expression vector. The siRNA is selected from the following: SEQ ID NO:1, SEQ ID NO:2. SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, or a combination thereof.

Abstract: Provided herein is a method for preventing or treating neurodegenerative disease in a subject, comprising administrating to the subject an effective amount of a composition which comprises a semen biotae extract. The neurodegenerative disease is associated with ?-synuclein, such as Alzheimer's disease, Parkinson's disease, Huntington disease, or Amyotrophic lateral sclerosis.

Abstract: Provided herein is a method for preventing or treating neurodegenerative disease in a subject, comprising administrating to the subject an effective amount of a composition which comprises a semen biotae extract. The neurodegenerative disease is associated with ?-synuclein, such as Alzheimer's disease, Parkinson's disease, Huntington disease, or Amyotrophic lateral sclerosis.

Abstract: Provided in the present invention are various labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases. Also provided in the present invention is a semen biotae extract comprising one or more labdane diterpenoid compounds and derivatives thereof for use in preparation of a pharmaceutical composition for preventing or treating neurodegenerative diseases.

Abstract: A mini-size universal hydraulic excavator capable of performing independently many operating processes, such as digging, pushing, grabbing, drilling and chipping, having essentially three main sections, namely, a chassis carrying traveling device pivotally connected with an earth-moving means, a complete swivel upper carriage provided with a power generator and a driver's seat, and an excavating arm having a boom, a bucket arm, and a bucket. A hydraulic chipper can be connected to the main machine without the necessity of removal of the bucket and the earth-moving means, so that chipping and site clearing can be carried on simultaneously solely by one single machine. A backhoe bucket carrying a scraper employs a multi-bar linkage mechanism having a bucket body, a scraper, and a bucket arm so that the bucket can have sufficient bucket capacity in a relatively greater excavating revolving angle range.