Patents by Inventor Zhong-Ru Gan

Zhong-Ru Gan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chaperone protein containing an intramolecular chaperone-like sequence and its application to insulin production
    Patent number: 6924120
    Abstract: The present invention relates to a chimeric protein containing an intramolecular chaperone (IMC) like sequence linked to a target protein, preferably an insulin precursor. The present invention also relates to a process for obtaining a correctly folded insulin-precursor-contain chimeric protein, comprising, inter alia, contacting an incorrectly folded chimeric protein containing an IMC like sequence linked to an insulin precursor with at least one chaotropic auxiliary agent. The present invention further relates to an assay for screening an amino acid sequence for the ability to improve folding of an insulin precursor using a chimeric protein containing an IMC like sequence linked to an insulin precursor.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: August 2, 2005
    Assignee: Tonghua Gantech Biotechnology, Ltd.
    Inventor: Zhong-Ru Gan
  • Chimeric protein containing an intramolecular chaperone-like sequence
    Publication number: 20020164712
    Abstract: The present invention relates to a chimeric protein containing an intramolecular chaperone (IMC) like sequence linked to a target protein, preferably an insulin precursor. The present invention also relates to a process for obtaining a correctly folded insulin-precursor-containing chimeric protein, comprising, inter alia, contacting an incorrectly folded chimeric protein containing an IMC like sequence linked to an insulin precursor with at least one chaotropic auxiliary agent. The present invention further relates to an assay for screening an amino acid sequence for the ability to improve folding of an insulin precursor using a chimeric protein containing an IMC like sequence linked to an insulin precursor.
    Type: Application
    Filed: January 22, 2002
    Publication date: November 7, 2002
    Applicant: Tonghua GanTech Biotechnology Ltd.
    Inventor: Zhong-Ru Gan