Abstract: The present disclosure relates to a liquid-cooling radiating pipe and a vacuum interrupter with a built-in liquid-cooling radiating pipe, belonging to the field of vacuum circuit breakers. Based on an original structure of an vacuum interrupter, a liquid-cooling radiating pipe of a Tesla valve structure is arranged in a conductive rod of the vacuum interrupter with the built-in liquid-cooling radiating pipe, and liquid metal is used as a circulating coolant in the liquid-cooling radiating pipe, and by using the self-circulating flow of the liquid metal in the pipeline, the capacity of the conductive rod to dissipate heat to the outside is significantly increased, and the problem of excessive internal temperature rise of a vacuum circuit breaker is effectively solved.

Abstract: An integrated circuit includes a first-voltage power rail and a second-voltage power rail in a first connection layer, and includes a first-voltage underlayer power rail and a second-voltage underlayer power rail below the first connection layer. Each of the first-voltage and second-voltage power rails extends in a second direction that is perpendicular to a first direction. Each of the first-voltage and second-voltage underlayer power rails extends in the first direction. The integrated circuit includes a first via-connector connecting the first-voltage power rail with the first-voltage underlayer power rail, and a second via-connector connecting the second-voltage power rail with the second-voltage underlayer power rail.

Abstract: An APFC converter control method includes: obtaining an output voltage, an input voltage and an inductor current of the APFC converter; obtaining a voltage adjustment value according to a voltage error value between a preset reference voltage and the output voltage; obtaining a reference current according to the voltage adjustment value and the input voltage; obtaining a current error value according to the reference current and the inductor current; obtaining an adjustment coefficient of the proportional integration parameter; adjusting an integration parameter and a proportional parameter according to the adjustment coefficient; calculating an output control value according to the integration parameter, the proportional parameter and the current error value; and comparing the control value with sawtooth harmonics to adjust the duty cycle and to output a PWM signal.

Abstract: A semiconductor device includes one or more active semiconductor components, wherein a front side is defined over the semiconductor substrate and a back side is defined beneath the semiconductor substrate. A front side power rail is formed at the front side of the semiconductor device and is configured to receive a first reference power voltage. First and second back side power rails are formed on the back side of the semiconductor substrate and are configured to receive corresponding second and third reference power voltages. The first, second and third reference power voltages are different from each other.

Abstract: A semiconductor device includes a first gate structure extending along a first lateral direction. The semiconductor device includes a first interconnect structure, disposed above the first gate structure, that extends along a second lateral direction perpendicular to the first lateral direction. The first interconnect structure includes a first portion and a second portion electrically isolated from each other by a first dielectric structure. The semiconductor device includes a second interconnect structure, disposed between the first gate structure and the first interconnect structure, that electrically couples the first gate structure to the first portion of the first interconnect structure. The second interconnect structure includes a recessed portion that is substantially aligned with the first gate structure and the dielectric structure along a vertical direction.

Abstract: Provided herein are cyclic polypeptide compounds that can, e.g., bind specifically to human proprotein convertase subtilisin/kexin type 9 (PCSK9) and optionally also inhibit interaction between human PCSK9 and human low density lipoprotein receptor (LDLR), and pharmaceutical compositions comprising one or more of these compounds. Also provided are methods of reducing LDL cholesterol level in a subject in need thereof that include administering to the subject one or more of the cyclic polypeptide compounds or a pharmaceutical composition provided herein.

Abstract: A method for modifying engine files, the method performed by at least one processor in one or more servers at a cloud based location, the method comprising receiving, by the one or more servers at the cloud based location from at least one host device, a derived data cache (DDC) generated by the at least one host device; distributing the DDC from the one or more servers at the cloud based location to one or more client locations, the one or more client locations performing at least one modification to the DDC; and receiving the modified DDC, by the one or more servers at the cloud based location from the one or more client locations.

Abstract: A sticking machine able to automatically remove films on either side of a sheet to be pasted to a workpiece includes a sheet supply component, a sheet selection component, a drive component, a first film-removing component, a second film-removing component, a carrier, and a transmission line. The sheet supply component stores sheets. The sheet selection component applies suction to the sheet. The first film-removing component tears off a first film, the second film-removing component tears off a second film on the reverse side. The transmission line carries the workpiece to the carrier. The sticking machine is fed by the sheet supply component, and after removal of the first film, the sheet selection component lays the sheet on the surface of the workpiece, then the second film-removing component tears off the second film, realizing automatic sticking of the sheet on the workpiece, improving the processing efficiency and accuracy.

Abstract: A computer-implemented method, system and computer program product for automatically drawing infographics. Variables of a dataset are received from a computing device that were selected by the user of the computing device. For those selected variables that are associated with a data model, a procedure to draw infographics for variables assigned or not assigned the role of a target using the data model associated with each of the variables assigned or not assigned the role of target, respectively, is implemented. Alternatively, if the selected variables are not associated with a data model, then such variables are assigned a level of measurement as well as assigned the role of input. Such assignments become the data model which, along with the metadata (e.g., values of the variable) obtained by parsing the original data, are used to implement the procedure to draw infographics for variables not assigned the role of a target.

Abstract: One or more computer processors determine a web segment in a web page to be displayed in a visual area and a rendering mode for the web segment. The one or more computer processors retrieve content in the web segment, wherein retrieving the content comprises: in response to the content being cached in a cache memory, retrieving, by one or more processors, the content from the cache memory. The one or more computer processors render the retrieved content to be displayed in the visual area according to the determined rendering mode for the web segment.

Abstract: Disclosed herein is method for the prevention, delay of progression or treatment of hepatocellular carcinoma in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of an anti-PD-1 antibody, which is an antibody or a fragment antigen binding thereof, specifically binding to human PD-1.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for detecting network attacks. One of the methods includes obtaining input data associated with a plurality of accounts associated with a particular entity; extracting features from the input data; performing unsupervised attack ring detection using the extracted features, wherein the unsupervised attack ring detection identifies suspicious clusters of accounts that have strong similarity or correlations in the high dimensional feature space; and generating an output for the detected attack rings.

Abstract: The disclosure relates to an expression method of a Haemocoagulase Acutus (Halase) recombinant protein. The method includes the following steps: (1) optimizing a halase gene; (2) performing Polymerase Chain Reaction (PCR) amplification on an optimized halase gene; (3) constructing an Agkis-pMCX expression vector, transforming plasmids to competent cells of an Escherichia coli for amplification, screening in an Amp-resistant manner for positive cloning, sequencing and extracting recombinant plasmids with correct sequencing; (4) transfecting recombinant plasmids to CHO cells; and (5) expressing the recombinant protein and identifying. According to the expression method, a recombinant halase is expressed first using the CHO cells cultured in a serum-free suspension manner; and by utilizing a bioengineering means, the actual production problems of insufficient raw material sources and unstable quality of a snake venom product are solved successfully.

Abstract: A method and system for detecting pin misalignment of ICs when being inserted into IC sockets includes a pressure sensing unit obtaining information as to pin insertion and pressure exerted by the pin and outputting the sensed information. A microprocessor receives the sensed information and obtains a pressure value correspondingly. Any misalignment of the pin is determined according to the pressure value so calculated.

Abstract: A three-way flow dividing valve structure is provided, including a valve body, a water divider, a spring, and a switch handle. A water intake communicating with the water inlet is formed on the side wall of the flow dividing chamber. A first and second outlet holes respectively communicating with the water outlets are formed at the bottom of the flow dividing chamber. The water divider includes a water dividing shaft and a water dividing dish; the bottom of the water dividing shaft is connected to the water dividing dish in the flow dividing chamber. The water dividing dish has a water dividing hole movably communicating with the outlet holes. The top of the water dividing shaft protrudes from the valve body and is connected to the switch handle. Two ends of the spring abut against the water dividing dish and the bonnet respectively. The present disclosure can be operated effortlessly.

Abstract: A connection structure of shower column systems includes fixing member, shower column body having containing cavity, connecting pipe communicating with water supply pipe, and hose in the containing cavity. The shower column body includes installation part having movement channel communicating with the containing cavity; the installation part is installed on the fixing member; the connecting pipe is in wall, an end thereof passes the movement channel to move axially; the hose communicates with water inlet of the shower column body and passes the movement channel to communicate with the connecting pipe. Flexible connection through the hose and connecting pipe makes more adjustment room than rigid connection. Distance between the connecting pipe and shower column body is adjusted by moving the connecting pipe in the movement channel. System adjustment and installation are quickly completed according to different depths of water supply pipes.

Abstract: A method and system for detecting pin misalignment of ICs when being inserted into IC sockets includes a pressure sensing unit obtaining information as to pin insertion and pressure exerted by the pin and outputting the sensed information. A microprocessor receives the sensed information and obtains a pressure value correspondingly. Any misalignment of the pin is determined according to the pressure value so calculated.

Abstract: The present disclosure provides oligonucleotides that comprise semi-random barcode sequences. Such oligonucleotides may be incorporated into reverse transcription primers, PCR primers, or portions of sequencing adapters in preparing sequencing libraries. The resulting sequencing libraries can be used for accurate sequencing, including DNA or RNA counting and mutation detection. Methods and kits for preparing sequencing adapters and sequencing libraries are also provided.

Abstract: A liquid pump mechanism for a soap dispenser includes a pump body, and an outlet tube, an upper wave-shaped pad, a piston, a spring, an annular internal sleeve, and a lower wave-shaped pad which are sequentially disposed inside the pump body from top down. A dividing member formed in the pump body divides an inner cavity of the pump body into a main chamber and an inlet chamber. An outlet passage is formed in the outlet tube. The outlet tube and the main chamber are movably sealed and engaged. The piston divides the main chamber into a compatible chamber and a liquid soap chamber. An outlet hole communicating the outlet passage and the liquid soap chamber is disposed on the piston. An inlet hole communicating the liquid soap chamber and the inlet chamber is disposed on the dividing member. The upper wave-shaped pad is disposed between the outlet tube and the piston and movably closes the outlet hole.

Abstract: A three-way flow dividing valve structure is provided, including a valve body, a water divider, a spring, and a switch handle. A water intake communicating with the water inlet is formed on the side wall of the flow dividing chamber. A first and second outlet holes respectively communicating with the water outlets are formed at the bottom of the flow dividing chamber. The water divider includes a water dividing shaft and a water dividing dish; the bottom of the water dividing shaft is connected to the water dividing dish in the flow dividing chamber. The water dividing dish has a water dividing hole movably communicating with the outlet holes. The top of the water dividing shaft protrudes from the valve body and is connected to the switch handle. Two ends of the spring abut against the water dividing dish and the bonnet respectively. The present disclosure can be operated effortlessly.