Patents by Inventor Zhongcheng MIN

Zhongcheng MIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Manufacture of compounds and compositions for inhibiting the activity of SHP2
    Patent number: 11873307
    Abstract: The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: January 16, 2024
    Assignee: NOVARTIS AG
    Inventors: Zhongbo Fei, Huanqing Jia, Wei Li, Xiaohui Lin, Zhongcheng Min, Hui Wang, Jianhua Wang, Hao Zhang
  • Chemical process for preparing phenylpiperidinyl indole derivatives
    Patent number: 11578053
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 9, 2021
    Date of Patent: February 14, 2023
    Assignee: Novartis AG
    Inventors: Peng Fu, Yu Gai, Feng Gao, Weiyong Kong, Yadong Lu, Zhongcheng Min, Shaofeng Rong, Chutian Shu, Can Wang, Ruidong Wang, Jibin Zhao, Xianglin Zhao, Yi Zhao, Jianguang Zhou, Benjamin Martin
  • CHEMICAL PROCESS FOR PREPARING PHENYLPIPERIDINYL INDOLE DERIVATIVES
    Publication number: 20220169630
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 9, 2021
    Publication date: June 2, 2022
    Inventors: Peng FU, Yu GAI, Feng GAO, Weiyong KONG, Yadong LU, Zhongcheng MIN, Shaofeng RONG, Chutian SHU, Can WANG, Ruidong WANG, Jibin ZHAO, Xianglin ZHAO, Yi ZHAO, Jianguang ZHOU, Benjamin MARTIN
  • Chemical process for preparing phenylpiperidinyl indole derivatives
    Patent number: 11208398
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: December 28, 2021
    Assignee: NOVARTIS AG
    Inventors: Peng Fu, Yu Gai, Feng Gao, Weiyong Kong, Yadong Lu, Zhongcheng Min, Shaofeng Rong, Chutian Shu, Can Wang, Ruidong Wang, Jibin Zhao, Xianglin Zhao, Yi Zhao, Jianguang Zhou, Benjamin Martin
  • MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2
    Publication number: 20210355134
    Abstract: The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.
    Type: Application
    Filed: September 18, 2019
    Publication date: November 18, 2021
    Inventors: Zhongbo Fei, Huanqing Jia, Wei Li, Xiaohui Lin, Zhongcheng Min, Hui Wang, Jianhua Wang, Hao Zhang
  • CHEMICAL PROCESS FOR PREPARING PHENYLPIPERIDINYL INDOLE DERIVATIVES
    Publication number: 20210269416
    Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1/-/-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 15, 2019
    Publication date: September 2, 2021
    Inventors: Peng FU, Yu GAI, Feng GAO, Weiyong KONG, Yadong LU, Zhongcheng MIN, Shaofeng RONG, Chutian SHU, Can WANG, Ruidong WANG, Jibin ZHAO, Xianglin ZHAO, Yi ZHAO, Jianguang ZHOU, Benjamin MARTIN
  • Aminoheteroaryl benzamides as kinase inhibitors
    Patent number: 10660888
    Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: May 26, 2020
    Assignee: NOVARTIS AG
    Inventors: Jeffrey T. Bagdanoff, Yu Ding, Wooseok Han, Zilin Huang, Qun Jiang, Xianming Jin, Xiang Kou, Patrick Lee, Mika Lindvall, Zhongcheng Min, Yue Pan, Sabina Pecchi, Keith Bruce Pfister, Daniel Poon, Vivek Rauniyar, Xiaojing Michael Wang, Qiong Zhang, Jianguang Zhou, Shejin Zhu
  • AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS
    Publication number: 20190247392
    Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
    Type: Application
    Filed: December 5, 2018
    Publication date: August 15, 2019
    Inventors: Jeffrey T. BAGDANOFF, Yu DING, Wooseok HAN, Zilin HUANG, Qun JIANG, Xianming JIN, Xiang KOU, Patrick LEE, Mika LINDVALL, Zhongcheng MIN, Yue PAN, Sabina PECCHI, Keith Bruce PFISTER, Daniel POON, Vivek RAUNIYAR, Xiaojing Michael WANG, Qiong ZHANG, Jianguang ZHOU, Shejin ZHU
  • Aminoheteroaryl benzamides as kinase inhibitors
    Patent number: 10188649
    Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: January 29, 2019
    Assignee: Novartis AG
    Inventors: Jeffrey T. Bagdanoff, Yu Ding, Wooseok Han, Zilin Huang, Qun Jiang, Xianming Jin, Xiang Kou, Patrick Lee, Mika Lindvall, Zhongcheng Min, Yue Pan, Sabina Pecchi, Keith Bruce Pfister, Daniel Poon, Vivek Rauniyar, Xiaojing Michael Wang, Qiong Zhang, Jianguang Zhou, Shejin Zhu
  • AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS
    Publication number: 20180028532
    Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
    Type: Application
    Filed: August 9, 2017
    Publication date: February 1, 2018
    Applicant: Novartis AG
    Inventors: Jeffrey T. BAGDANOFF, Yu DING, Wooseok HAN, Zilin HUANG, Qun JIANG, Xianming JIN, Xiang KOU, Patrick LEE, Mika LINDVALL, Zhongcheng MIN, Yue PAN, Sabina PECCHI, Keith Bruce PFISTER, Daniel POON, Vivek RAUNIYAR, Xiaojing Michael WANG, Qiong ZHANG, Jianguang ZHOU, Shejin ZHU
  • Aminoheteroaryl benzamides as kinase inhibitors
    Patent number: 9763937
    Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: September 19, 2017
    Assignee: Novartis AG
    Inventors: Jeffrey T. Bagdanoff, Yu Ding, Wooseok Han, Zilin Huang, Qun Jiang, Xianming Jin, Xiang Kou, Patrick Lee, Mika Lindvall, Zhongcheng Min, Yue Pan, Sabina Pecchi, Keith Bruce Pfister, Daniel Poon, Vivek Rauniyar, Xiaojing Michael Wang, Qiong Zhang, Jianguang Zhou, Shejin Zhu
  • AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS
    Publication number: 20170182038
    Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
    Type: Application
    Filed: December 9, 2015
    Publication date: June 29, 2017
    Applicant: Novartis AG
    Inventors: Jeffrey T. BAGDANOFF, Yu DING, Wooseok HAN, Zilin HUANG, Qun JIANG, Xianming JIN, Xiang KOU, Patrick LEE, Mika LINDVALL, Zhongcheng MIN, Yue PAN, Sabina PECCHI, Keith Bruce PFISTER, Daniel POON, Vivek RAUNIYAR, Xiaojing Michael WANG, Qiong ZHANG, Jianguang ZHOU, Shejin ZHU
  • Aminoheteroaryl benzamides as kinase inhibitors
    Patent number: 9242996
    Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: January 26, 2016
    Assignee: Novartis AG
    Inventors: Jeffrey T. Bagdanoff, Yu Ding, Wooseok Han, Zilin Huang, Qun Jiang, Jeff Xianming Jin, Xiang Kou, Patrick Lee, Mika Lindvall, Zhongcheng Min, Yue Pan, Sabina Pecchi, Keith Bruce Pfister, Daniel Poon, Vivek Rauniyar, Xiaojing Michael Wang, Qiong Zhang, Jianguang Zhou, Shejin Zhu
  • AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS
    Publication number: 20150126490
    Abstract: The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.
    Type: Application
    Filed: October 29, 2014
    Publication date: May 7, 2015
    Applicant: Novartis AG
    Inventors: Jeffrey T. BAGDANOFF, Yu DING, Wooseok HAN, Zilin HUANG, Qun JIANG, Jeff Xianming JIN, Xiang KOU, Patrick LEE, Mika LINDVALL, Zhongcheng MIN, Yue PAN, Sabina PECCHI, Keith Bruce PFISTER, Daniel POON, Vivek RAUNIYAR, Xiaojing Michael WANG, Qiong ZHANG, Jianguang ZHOU, Shejin ZHU