Patents by Inventor Zhongguo Fu

Zhongguo Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Target Ligand
    Publication number: 20240067971
    Abstract: The present disclosure relates to the technical field of genetic engineering, in particular to a target ligand. The target ligand provided by the present disclosure forms a siRNA conjugate with a specific small interfering RNA sequence, which targets to an angiopoietin like 3 (ANGPTL3), and reduce the expression quantity of an ANGPTL3 protein by degrading a transcript of an ANGPTL3 gene in a cell. Therefore, the siRNA conjugate formed by the target ligand provided by the present disclosure may be used to prevent and/or treat a dyslipidemia disease.
    Type: Application
    Filed: April 3, 2023
    Publication date: February 29, 2024
    Inventors: Zhaogui Liu, Ping Chen, Jieting Zhang, Rui Wang, Juan Xu, Zhongguo Fu, Hailin Zhang, Pu Chen
  • SIRNA OF ANGPTL3 AND USE THEREOF
    Publication number: 20230257750
    Abstract: The present disclosure relates to the technical field of genetic engineering, in particular to a siRNA of an angiopoietin like 3 (ANGPTL3) and a use thereof. The inventor of the present disclosure targets to ANGPTL3 by designing an appropriate specific small interfering RNA sequence and a siRNA conjugate, and reduce the expression of an ANGPTL3 protein by degrading a transcript of an ANGPTL3 gene in a cell. Therefore, the siRNA provided in the present disclosure may be used to prevent and/or treat a dyslipidemia disease.
    Type: Application
    Filed: December 30, 2022
    Publication date: August 17, 2023
    Inventors: Ping Chen, Zhaogui Liu, Jieting Zhang, Rui Wang, Juan Xu, Zhongguo Fu, Hailin Zhang, Pu Chen