Abstract: The present invention provides an azaheteroaryl compound, a pharmaceutically acceptable salt thereof, and a solvate thereof. The present invention also provides a preparation method for such a compound, a composition containing such a compound, and a pharmaceutical use of such a compound in the preparation of a drug for treating a disease or disorder related to the mechanism of action of an EED protein and/or a PRC2 protein compound.

Abstract: The present disclosure relates to the technical field of genetic engineering, in particular to a target ligand. The target ligand provided by the present disclosure forms a siRNA conjugate with a specific small interfering RNA sequence, which targets to an angiopoietin like 3 (ANGPTL3), and reduce the expression quantity of an ANGPTL3 protein by degrading a transcript of an ANGPTL3 gene in a cell. Therefore, the siRNA conjugate formed by the target ligand provided by the present disclosure may be used to prevent and/or treat a dyslipidemia disease.

Abstract: Disclosed is a multi-mode electro-hydraulic brake boosting system and a control method thereof. When the boosting system fails, an emergency mechanical braking mode is achieved through structural redundancy, in a normal boosting mode, the system has a general braking mode and an emergency braking mode according to the strength requirements of a brake, and a general brake boosting mode and an emergency active pressurizing mode are controlled, respectively. Accurate boosting can be provided in the general braking process so that the pressure of a brake master cylinder can accurately follow target pressure, pressure buildup of the brake master cylinder can be completed more quickly in the emergency braking process, braking force is output to the maximum extent, the system response time of an emergency braking working condition is shortened, the braking capacity is improved, and traffic accidents are avoided.

Abstract: The present invention provides an iterative joint estimation method of vehicle mass and road gradient based on MMRLS and SH-STF, which includes the following steps: establishment of a dynamic model considering steering, MMRLS/SH-STF iterative joint estimation algorithm architecture, improved slope estimation algorithm based on SH-STF. It is an iterative joint estimation method of vehicle mass and road slope based on MMRLS and SH-STF, which is designed reasonably, and the slow-variation characteristics of vehicle mass and the time-varying characteristics of road gradient are analyzed. According to the characteristics of gradual change and time change, based on the longitudinal dynamics model of the vehicle and the steering single-track model, the system identification algorithm of multi-model fusion recursive least squares is used to calculate the vehicle mass, and the noise adaptive strong tracking based on extended Kalman filter is used.

Abstract: Disclosed in the present disclosure are an azaheteroaryl compound, a pharmaceutically acceptable salt thereof, and a solvate thereof. The present disclosure also provides a method for preparing said compound, a composition containing said compound, and a use of said compound in the preparation of a drug for treating a disease or disorder related to the mechanism of action of an EED protein and/or a PRC2 protein complex.

Abstract: The present invention relates to a commercial vehicle disc brake caliper assembly comprising a caliper body and a left guide pin component, right guide pin component, the main adjuster mechanism assembly, the driven adjuster unit are all mounted on the caliper body. The adjuster mechanism assembly adopts a gear clutch structure with anti-overload function; the driven adjuster unit adopts a circlip structure; the main adjuster assembly and the driven adjuster unit is connected by sprocket chain. The bottom of the main adjuster assembly and the bottom of the driven adjuster unit are connected to the three thread calibration bolt, which connected with bridage, the bridage are arranged inside of the brake caliper. The invention overcomes the problems which may occur during braking, such as uneven braking force, failure of clearance adjustment, deformation of adjuster mechanism, failure of braking, etc.

Abstract: Disclosed is a multi-mode electro-hydraulic brake boosting system and a control method thereof. When the boosting system fails, an emergency mechanical braking mode is achieved through structural redundancy, in a normal boosting mode, the system has a general braking mode and an emergency braking mode according to the strength requirements of a brake, and a general brake boosting mode and an emergency active pressurizing mode are controlled, respectively. Accurate boosting can be provided in the general braking process so that the pressure of a brake master cylinder can accurately follow target pressure, pressure buildup of the brake master cylinder can be completed more quickly in the emergency braking process, braking force is output to the maximum extent, the system response time of an emergency braking working condition is shortened, the braking capacity is improved, and traffic accidents are avoided.

Abstract: The present invention relates to a commercial vehicle disc brake caliper assembly comprising a caliper body and a left guide pin component, right guide pin component, the main adjuster mechanism assembly, the driven adjuster unit are all mounted on the caliper body. The adjuster mechanism assembly adopts a gear cluth structure with anti-overload function; the driven adjuster unit adopts a circlip structure; the main adjuster assembly and the driven adjuster unit is connected by sprocket chain. The bottom of the main adjuster assembly and the bottom of the driven adjuster unit are connected to the three thread calibration bolt, which connected with bridage, the bridage are arranged inside of the brake caliper. The invention overcomes the problems which may occur during brakeing, such as uneven braking force, failure of clearance adjustment, deformation of adjuster mechanism, failure of braking, etc.