Abstract: Presently provided are inhibitors of TD02 and IDO1 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2,3 dioxygenase and indoleamine 2,3-dioxygenase 1; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

Abstract: Accuracy for detecting and tracking one or more objects of interest can be improved using radar-based tracking systems. In some examples, multiple radars implemented in a device can be used to transmit signals to, and receive signals from, the one or more objects of interest. To disambiguate an object of interest from undesired objects such as the hand of a user, the object of interest can include a transponder that applies a delay element to a signal received from a radar, and thereafter transmits a delayed return signal back to the radar. The delay produced by the delay element can separate the return signal from undesired reflections and enable disambiguation of those signals. Clear identification of the desired return signal can lead to more accurate object distance determinations, more accurate triangulation, and improved position detection and tracking accuracy.

Abstract: A flow splitting device for gas reverse circulation drilling, including: an upper joint for connecting with a double-wall drill pipe; an inner tube which is arranged in the upper joint and defines a first passageway in communication with an inner chamber of the double-wall drill pipe, a second passageway in communication with an annular space in the double-wall drill pipe formed between the inner tube and the upper joint; a lower joint, having an upper end fixedly connected with the upper joint and a lower end for connecting with a drill tool; and a flow guiding member provided between the upper joint and the lower joint. A flexible sealing mechanism is provided outside the upper joint. The flexible sealing mechanism extends radially outward relative to the upper joint and the lower joint to form a sealing contact with a wellbore wall.

Abstract: In some implementations, a substrate for coupling to an integrated circuit includes multiple layers. Each of the multiple layers has, in a particular region of the substrate, a repeating pattern of regions corresponding to power and ground. The multiple layers include (i) a top layer having, in the particular region, power contacts and ground contacts for coupling to an integrated circuit and (ii) a bottom layer having, in the particular region, power contacts and ground contacts for coupling to another device. At least one layer of the multiple layers has a repeating pattern of signal traces that extend along and are located between the regions corresponding to ground in the at least one layer.

Abstract: Embodiments of the present disclosure relate to a D-amino acid oxidase mutant and application in preparing L-glufosinate thereof. The D-amino acid oxidase mutant has an amino acid substitution at at least one of position 62 and position 226 of an amino acid sequence of the D-amino acid oxidase mutant when compared to an amino acid sequence of a D-amino acid oxidase as set forth in SEQ ID NO. 1, the position 62 and position 226 being defined with reference to SEQ ID NO. 1, and the amino acid sequence of the D-amino acid oxidase mutant having at least 90% identity to SEQ ID NO. 1.

Abstract: A vehicle starting power supply is provided, which includes a control module; a charging and discharging circuit, an input of which is connected with an output of the control module, the charging and discharging circuit being configured for charging and discharging a lithium battery; a battery voltage detection circuit, an input of which is connected with an automobile battery, an output of the battery voltage detection circuit being connected with an input of the control module; a battery reverse connection detection circuit, an input of which is connected with the automobile battery, an output of the battery reverse connection detection circuit being connected with the input of the control module; an alarm response circuit, an input of which is connected with the output of the control module; and a relay driving circuit being configured for connecting or disconnecting a discharge circuit between the lithium battery and the automobile battery.

Abstract: An automobile charger, a charging method and a medium are provided. The charger includes a MCU, a switching power supply circuit, a first and second charging circuits, a battery voltage detection circuit, a charging current detection circuit, a constant-current driving control circuit, a constant-voltage driving control circuit and a switch driving control circuit. The charger is provided with the first and second charging circuits, which can realize three charging modes on the battery. The real-time voltage signal and the real-time current signal are collected with the battery voltage detection circuit and the charging current detection circuit, and through feedback of the real-time voltage signal and the real-time current signal, the MCU is configured to output PWM signals with different duty ratios to the constant-current driving control circuit and the constant-voltage driving control circuit, so as to realize output of different voltage values and current values of the switching power supply.

Abstract: In some implementations, a substrate for coupling to an integrated circuit includes multiple layers. Each of the multiple layers has, in a particular region of the substrate, a repeating pattern of regions corresponding to power and ground. The multiple layers include (i) a top layer having, in the particular region, power contacts and ground contacts for coupling to an integrated circuit and (ii) a bottom layer having, in the particular region, power contacts and ground contacts for coupling to another device. At least one layer of the multiple layers has a repeating pattern of signal traces that extend along and are located between the regions corresponding to ground in the at least one layer.

Abstract: A flow splitting device for gas reverse circulation drilling, including: an upper joint for connecting with a double-wall drill pipe; an inner tube which is arranged in the upper joint and defines a first passageway in communication with an inner chamber of the double-wall drill pipe, a second passageway in communication with an annular space in the double-wall drill pipe formed between the inner tube and the upper joint; a lower joint, having an upper end fixedly connected with the upper joint and a lower end for connecting with a drill tool; and a flow guiding member provided between the upper joint and the lower joint. A flexible sealing mechanism is provided outside the upper joint. The flexible sealing mechanism extends radially outward relative to the upper joint and the lower joint to form a sealing contact with a wellbore wall.

Abstract: A luggage zipper lock and a luggage, including a lock and a zipper, wherein the zipper includes a slider and a puller, the puller being provided on the slider, a first end of the slider is provided with a locking portion corresponding to the lock; when in a locked state, the locking portion on the slider is inserted into the lock and locked; when in an unlocked state, the lock is unlocked, and the locking portion on the slider can be pulled out from the lock. By moving the locked portion from the puller to the slider, the function of locking by pulling the slider is realized, which is simpler as compared to locking by buckling the puller into a lock hook, and the locking portion corresponds to the lock, so that only the zipper is pulled without making mistakes.

Abstract: In some implementations, a substrate for coupling to an integrated circuit includes multiple layers. Each of the multiple layers has, in a particular region of the substrate, a repeating pattern of regions corresponding to power and ground. The multiple layers include (i) a top layer having, in the particular region, power contacts and ground contacts for coupling to an integrated circuit and (ii) a bottom layer having, in the particular region, power contacts and ground contacts for coupling to another device. At least one layer of the multiple layers has a repeating pattern of signal traces that extend along and are located between the regions corresponding to ground in the at least one layer.

Abstract: A cable connector, a cable clamp, and a method for detecting bridging of car batteries. The cable connector includes a housing and a wiring circuit, wherein the wiring circuit is arranged in the housing and includes a first wiring terminal, a second wiring terminal, and a detection module and voltage absorption module electrically connected between the first wiring terminal and the second wiring terminal, and a voltage absorption module. The voltage absorption module includes a piezoresistor bridged between the first wiring terminal and the second wiring terminal. The detection module includes a first switch circuit and a second switch circuit which are oppositely bridged between the first wiring terminal and the second wiring terminal to be alternatively turned on, wherein the first switch circuit includes a first illumination unit, and the second switch circuit includes a second illumination unit.

Abstract: In some implementations, a substrate for coupling to an integrated circuit includes multiple layers. Each of the multiple layers has, in a particular region of the substrate, a repeating pattern of regions corresponding to power and ground. The multiple layers include (i) a top layer having, in the particular region, power contacts and ground contacts for coupling to an integrated circuit and (ii) a bottom layer having, in the particular region, power contacts and ground contacts for coupling to another device. At least one layer of the multiple layers has a repeating pattern of signal traces that extend along and are located between the regions corresponding to ground in the at least one layer.

Abstract: Accuracy for detecting and tracking one or more objects of interest can be improved using radar-based tracking systems. In some examples, multiple radars implemented in a device can be used to transmit signals to, and receive signals from, the one or more objects of interest. To disambiguate an object of interest from undesired objects such as the hand of a user, the object of interest can include a transponder that applies a delay element to a signal received from a radar, and thereafter transmits a delayed return signal back to the radar. The delay produced by the delay element can separate the return signal from undesired reflections and enable disambiguation of those signals. Clear identification of the desired return signal can lead to more accurate object distance determinations, more accurate triangulation, and improved position detection and tracking accuracy.

Abstract: A cable connector, a cable clamp, and a method for detecting bridging of car batteries. The cable connector includes a housing and a wiring circuit, wherein the wiring circuit is arranged in the housing and includes a first wiring terminal, a second wiring terminal, and a detection module and voltage absorption module electrically connected between the first wiring terminal and the second wiring terminal, and a voltage absorption module. The voltage absorption module includes a piezoresistor bridged between the first wiring terminal and the second wiring terminal. The detection module includes a first switch circuit and a second switch circuit which are oppositely bridged between the first wiring terminal and the second wiring terminal to be alternatively turned on, wherein the first switch circuit includes a first illumination unit, and the second switch circuit includes a second illumination unit.

Abstract: In some implementations, a substrate for coupling to an integrated circuit includes multiple layers. Each of the multiple layers has, in a particular region of the substrate, a repeating pattern of regions corresponding to power and ground. The multiple layers include (i) a top layer having, in the particular region, power contacts and ground contacts for coupling to an integrated circuit and (ii) a bottom layer having, in the particular region, power contacts and ground contacts for coupling to another device. At least one layer of the multiple layers has a repeating pattern of signal traces that extend along and are located between the regions corresponding to ground in the at least one layer.

Abstract: A luggage zipper lock and a luggage, including a lock and a zipper, wherein the zipper includes a slider and a puller, the puller being provided on the slider, a first end of the slider is provided with a locking portion corresponding to the lock; when in a locked state, the locking portion on the slider is inserted into the lock and locked; when in an unlocked state, the lock is unlocked, and the locking portion on the slider can be pulled out from the lock. By moving the locked portion from the puller to the slider, the function of locking by pulling the slider is realized, which is simpler as compared to locking by buckling the puller into a lock hook, and the locking portion corresponds to the lock, so that only the zipper is pulled without making mistakes.