Patents by Inventor Zhongju Lu

Zhongju Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Two Pore Channels as a Therapeutic Target to Protect Against Myocardial Ischemia and as an Adjuvant in Cardiac Surgery
    Publication number: 20140113314
    Abstract: The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarction or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.
    Type: Application
    Filed: November 29, 2012
    Publication date: April 24, 2014
    Applicants: The Research Foundation of State University of New York, The Trustees of Columbia University in the City of New York
    Inventors: Ira S. Cohen, Zhongju Lu, Richard B. Robinson, Irvin B. Krukenkamp, Peter R. Brink, Steven J. Feinmark
  • OPTICAL CONTROL OF CARDIAC FUNCTION
    Publication number: 20130274838
    Abstract: The invention features an optically-controlled biological device that includes a biological component comprising a non-excitable cell expressing a light-gated ion channel protein and capable of forming gap junction channels with a target cell, and an optical stimulation unit.
    Type: Application
    Filed: October 18, 2011
    Publication date: October 17, 2013
    Applicant: The Research Foundation of State University of New York
    Inventors: Emilia Entcheva, Zhiheng Jia, Zhongju Lu, Harold Bien, Ira S. Cohen
  • TWO PORE CHANNELS AS A THERAPEUTIC TARGET TO PROTECT AGAINST MYOCARDIAL ISCHEMIA AND AS AN ADJUVANT IN CARDIAC SURGERY
    Publication number: 20100048650
    Abstract: The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarcation or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.
    Type: Application
    Filed: April 4, 2007
    Publication date: February 25, 2010
    Inventors: Ira S. Cohen, Zhongju Lu, Irvin Krukenkamp, Peter R. Brink, Richard B. Robinson, Steven J. Feinmark