Abstract: The present disclosure relates to the discovery that certain ocular diseases may be treated using Edonentan crystalline forms. Specific Edonentan crystalline form can be used alone or in combination with an intra-ocular pressure (TOP) reducing agent, a neuroprotective agent, or an anti-VEGF agent. Using Edonentan crystalline forms, alone or in combination with an additional agent, provides increased perfusion to the retina or reduced TOP in certain ocular diseases and reduces damage to retinal cells.

Abstract: The present disclosure relates to the discovery that certain ocular diseases may be treated using Edonentan crystalline forms. Specific Edonentan crystalline form can be used alone or in combination with an intra-ocular pressure (TOP) reducing agent, a neuroprotective agent, or an anti-VEGF agent. Using Edonentan crystalline forms, alone or in combination with an additional agent, provides increased perfusion to the retina or reduced IOP in certain ocular diseases and reduces damage to retinal cells.

Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.

Abstract: The present disclosure relates to the discovery that certain ocular diseases may be treated using Edonentan crystalline forms. Specific Edonentan crystalline form can be used alone or in combination with an intra-ocular pressure (TOP) reducing agent, a neuroprotective agent, or an anti-VEGF agent. Using Edonentan crystalline forms, alone or in combination with an additional agent, provides increased perfusion to the retina or reduced IOP in certain ocular diseases and reduces damage to retinal cells.

Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.

Abstract: Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.

Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.

Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.

Abstract: Devices and methods for using and manufacturing microstructure arrays are described.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing asynchronous and synchronous links to resources. According to one example implementation, a method includes receiving a request for a resource, identifying resources to be referenced by the requested resource, and identifying one or more of the referenced resources that are associated with client-side click tracking, and one or more of the referenced resources that are associated with server-side click tracking. The method also includes providing the requested resource. The provided resource includes one or more client-side click tracking links to the referenced resources that are associated with client-side click tracking, and one or more server-side click tracking links to the referenced resources that are associated with server-side click tracking.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing client-side click tracking. In one aspect, a method includes receiving, by a client, a resource from one or more servers. The resource includes (i) a link, (ii) click tracking code, and (iii) local storage monitoring code. The method includes invoking, by the client, the click tracking code and the local storage monitoring code, detecting, by the invoked click tracking code, a selection of the link, and generating, by the invoked click tracking code, a representation of the selection. The method includes storing, by the invoked click tracking code, the representation of the selection in a local storage on the client, determining, by the invoked local storage monitoring code, to communicate the representation of the selection; and communicating, by the invoked local storage monitoring code, the representation of the selection to the one or more servers.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing asynchronous and synchronous links to resources. According to one example implementation, a method includes receiving a request for a resource, identifying resources to be referenced by the requested resource, and identifying one or more of the referenced resources that are associated with client-side click tracking, and one or more of the referenced resources that are associated with server-side click tracking. The method also includes providing the requested resource. The provided resource includes one or more client-side click tracking links to the referenced resources that are associated with client-side click tracking, and one or more server-side click tracking links to the referenced resources that are associated with server-side click tracking.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing asynchronous and synchronous links to resources. According to one example implementation, a method includes receiving a request for a resource, identifying resources to be referenced by the requested resource, and identifying one or more of the referenced resources that are associated with client-side click tracking, and one or more of the referenced resources that are associated with server-side click tracking. The method also includes providing the requested resource. The provided resource includes one or more client-side click tracking links to the referenced resources that are associated with client-side click tracking, and one or more server-side click tracking links to the referenced resources that are associated with server-side click tracking.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for adjusting facial image search results. In one aspect, a method includes detecting, in images that are responsive to a query, faces in the images and building facial templates. The images are then clustered according to similarity measures of the facial templates. The cluster with the highest quantity is selected, and each image in the set of returned images is compared to each image in the selected cluster. The similarity of each face with the faces in the largest cluster, based on the facial templates, is determined as an inlier score for the image in which the face is depicted. The system then increases the rank of images with high inlier scores and decreases the rank of images with low inlier scores.

Abstract: Methods, systems and apparatus for identifying modified images based on seed images that are known to be modified images. In an aspect, a method includes accessing data identifying a set of first seed images; for each first seed image, determining a respective first set of similar images from images in an image corpus, each similar image having a visual similarity score that is a measure of visual similarity of the similar image to the first seed image based on the image content of the similar image and the first seed image that satisfies a first seed image similarity threshold; and for each similar image in each respective first set of similar images, attributing to the similar image signal data of each first seed image for which the similar image has a respective visual similarity score satisfying the first seed image similarity threshold.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for adjusting facial image search results. In one aspect, a method includes detecting, in images that are responsive to a query, faces in the images and building facial templates. The images are then clustered according to similarity measures of the facial templates. The cluster with the highest quantity is selected, and each image in the set of returned images is compared to each image in the selected cluster. The similarity of each face with the faces in the largest cluster, based on the facial templates, is determined as an inlier score for the image in which the face is depicted. The system then increases the rank of images with high inlier scores and decreases the rank of images with low inlier scores.