Patents by Inventor Zhongliang XIAO
Zhongliang XIAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11939625Abstract: A method and a sensor for detecting L-cystine are disclosed. The method is implemented by assembling a sodium 3,3?-dithiodipropane sulfonate (SPS) membrane on a surface of Au membrane layer of an Au electrode and using an extended gate of field effect transistor (FET) and in-situ signal amplification of the FET to detect L-cystine sensitively. The polyanion of the SPS membrane adsorbs and binds a positively charged target L-cystine through electrostatic interaction, thus forming an electric double layer structure to generate a membrane potential identifying a monovalent organic ammonium ion. The sensor includes the FET, wherein a gate-extended gold electrode is arranged on the FET, and the SPS membrane is assembled on the surface of the Au membrane layer of the gate-extended gold electrode. The sensor has an excellent Nernst response to L-cystine.Type: GrantFiled: August 24, 2019Date of Patent: March 26, 2024Assignee: CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Zhong Cao, Jia Yang, Chen Liu, Zhongliang Xiao, Dan Li, Ling Zhang, Yuyang Zhang, Jiaxin Li
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Publication number: 20230322991Abstract: The present invention provides a perfluoroether fluororubber and a preparation method therefor and use thereof. The perfluoroether fluororubber is prepared by a stepwise polymerization method, wherein polymerization monomers in each step of polymerization comprise tetrafluoroethylene and a perfluoroalkyl vinyl ether. The preparation method for the perfluoroether fluororubber provided in the present invention can shorten polymerization time and improve production efficiency, and the finally obtained perfluoroether fluororubber is good in processability, high in strength, low in hardness and compression deformation and good in medium resistance.Type: ApplicationFiled: May 12, 2021Publication date: October 12, 2023Inventors: Jinlong YU, Bo LIU, Ziqiang ZHONG, Tingjian ZHANG, Zhongliang XIAO
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Patent number: 11774455Abstract: A peptide aptamer for specific recognition of arginine and its application are provided. The sequence of the peptide aptamer is shown in SEQ ID No. 1. The peptide aptamer is modified by a group that improves stability, or by a fluorescent group, an isotope and an electrochemical group that provide a detection signal, or by an affinity ligand and a mercapto. According to the computer-aided molecular docking simulation prediction, the peptide aptamer that can specifically bind to L-arginine is screened, which is verified by an isothermal titration calorimeter. The peptide aptamer has the advantages of good stability, strong binding ability, high specificity and low production cost.Type: GrantFiled: November 16, 2019Date of Patent: October 3, 2023Assignee: INSTITUTE OF SUBTROPICAL AGRICULTURE, CHINESE ACADEMY OF SCIENCESInventors: Zemeng Feng, Yumin He, Lei Deng, Zhong Cao, Zhongliang Xiao, Yulong Yin
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Patent number: 11761922Abstract: A method and a sensor for detecting L-arginine are provided. The method includes synthesizing ferrocene-functionalized hexadecapeptide dithiocyclopentane (FC-P16 Peptide), preparing a polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE), detecting L-Arg and other steps. The results show that the polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE) exhibits excellent electrochemical response properties to L-Arg. In 10 mmol/L phosphate-buffered saline (PBS, pH=7.4), the DPV response peak current of the polypeptide composite membrane-modified electrode has an excellent linear relationship with the L-Arg concentration of 1.0×10?13 mol/L to 1.0×10?7 mol/L, with a detection limit of 1.0×10?13 mol/L. With prominent reproducibility, repeatability and selectivity, the modified electrode has potential application in life science and nutritional health.Type: GrantFiled: December 31, 2019Date of Patent: September 19, 2023Assignee: CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Zhong Cao, Ningtao Zhou, Li Zhou, Qin Zhu, Jinglin He, Zhongliang Xiao, Yumin He, Zemeng Feng, Yulong Yin
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Publication number: 20230101196Abstract: A method and a sensor for detecting L-arginine are provided. The method includes synthesizing ferrocene-functionalized hexadecapeptide dithiocyclopentane (FC-P16 Peptide), preparing a polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE), detecting L-Arg and other steps. The results show that the polypeptide composite membrane-modified electrode (FC-P16 Peptide/AuE) exhibits excellent electrochemical response properties to L-Arg. In 10 mmol/L phosphate-buffered saline (PBS, pH=7.4), the DPV response peak current of the polypeptide composite membrane-modified electrode has an excellent linear relationship with the L-Arg concentration of 1.0×10?13 mol/L to 1.0×10?7 mol/L, with a detection limit of 1.0×10?13 mol/L. With prominent reproducibility, repeatability and selectivity, the modified electrode has potential application in life science and nutritional health.Type: ApplicationFiled: December 31, 2019Publication date: March 30, 2023Applicant: CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Zhong CAO, Ningtao ZHOU, Li ZHOU, Qin ZHU, Jinglin HE, Zhongliang XIAO, Yumin HE, Zemeng FENG, Yulong YIN
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Publication number: 20230047022Abstract: The present invention relates to the field of air filtration, in particular to a polytetrafluoroethylene composite filter material and a preparation method and uses thereof. The polytetrafluoroethylene composite filter material comprises a support layer and a polytetrafluoroethylene microporous membrane layer, and the support layer and the polytetrafluoroethylene microporous membrane layer are compounded by an adhesive, wherein the adhesive comprises a two-component polyurethane adhesive, a pore forming agent and an inorganic filler.Type: ApplicationFiled: August 24, 2020Publication date: February 16, 2023Inventors: Jia Li, Zhongliang Xiao, Ping Xiao, Hui Li, Fan Yang, Chunyang Cai
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Publication number: 20230045147Abstract: The present invention relates to the field of air filtration, in particular to a polytetrafluoroethylene composite filter material. The polytetrafluoroethylene composite filter material comprises a supporting layer and a polytetrafluoroethylene film layer, wherein the supporting layer is a silver-plated carbon nanomaterial-modified meltblown nonwoven fabric. The polytetrafluoroethylene composite filter material is prepared by fiberizing a resin material modified by silver-plated carbon nanomaterial on the surface of a polytetrafluoroethylene film by a melt-blowing method. The polytetrafluoroethylene composite filter material of the present invention combines filtering and sterilizing functions, has higher filtering efficiency and filtering precision, has the functions of sterilizing and killing viruses, has a good isolation effect, and greatly prolongs the service life of the filter material.Type: ApplicationFiled: August 24, 2020Publication date: February 9, 2023Inventors: Ping XIAO, Zhongliang XIAO, Chunyang CAI, Yi TANG, Hui LI, Jian SU
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Publication number: 20220298278Abstract: The present invention provides a method for controlling Mooney viscosity of peroxide-cured fluororubber. The method comprises: adding an initiator solution in a continuous supplementary manner during the emulsion polymerization process of a peroxide-cured fluororubber until 5 to 10 minutes before the end of the polymerization reaction; wherein the amount of the initiator solution added initially is 0.1% to 0.5% of the total amount of the polymerization monomer dry materials, and the amount of the initiator solution continuously supplemented is 0.1% to 2% of the total amount of the polymerization monomer dry materials, based on the initiator. The present invention effectively controls the Mooney viscosity value of the peroxide-cured fluororubber within the desired range with small fluctuations by controlling the amount and the manner of addition of the initiator, thereby obtaining a peroxide-cured fluororubber with stable and controllable quality.Type: ApplicationFiled: August 17, 2020Publication date: September 22, 2022Applicant: Zhonghao Chenguang Research Institute of Chemical Industry Co., Led.Inventors: Jinlong Yu, Bo Liu, Ziqiang Zhong, Tingjian Zhang, Zhongliang Xiao
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Publication number: 20220260582Abstract: A peptide aptamer for specific recognition of arginine and its application are provided. The sequence of the peptide aptamer is shown in SEQ ID No. 1. The peptide aptamer is modified by a group that improves stability, or by a fluorescent group, an isotope and an electrochemical group that provide a detection signal, or by an affinity ligand and a mercapto. According to the computer-aided molecular docking simulation prediction, the peptide aptamer that can specifically bind to L-arginine is screened, which is verified by an isothermal titration calorimeter. The peptide aptamer has the advantages of good stability, strong binding ability, high specificity and low production cost.Type: ApplicationFiled: November 16, 2019Publication date: August 18, 2022Applicant: INSTITUTE OF SUBTROPICAL AGRICULTURE, CHINESE ACADEMY OF SCIENCESInventors: Zemeng FENG, Yumin HE, Lei DENG, Zhong CAO, Zhongliang XIAO, Yulong YIN
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Patent number: 11079353Abstract: A method and a sensor for detecting L-cysteine based on a 3,3?-dithiobis (1-propanesulfonate)-mercury composite membrane are provided.Type: GrantFiled: August 24, 2019Date of Patent: August 3, 2021Assignee: CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Zhong Cao, Yuyu Peng, Chen Liu, Ling Tang, Qin Zhu, Min Jin, Jinglin He, Zhongliang Xiao
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Publication number: 20210123093Abstract: A method and a sensor for detecting L-cystine are disclosed. The method is implemented by assembling a sodium 3,3?-dithiodipropane sulfonate (SPS) membrane on a surface of Au membrane layer of an Au electrode and using an extended gate of field effect transistor (FET) and in-situ signal amplification of the FET to detect L-cystine sensitively. The polyanion of the SPS membrane adsorbs and binds a positively charged target L-cystine through electrostatic interaction, thus forming an electric double layer structure to generate a membrane potential identifying a monovalent organic ammonium ion. The sensor includes the FET, wherein a gate-extended gold electrode is arranged on the FET, and the SPS membrane is assembled on the surface of the Au membrane layer of the gate-extended gold electrode. The sensor has an excellent Nernst response to L-cystine.Type: ApplicationFiled: August 24, 2019Publication date: April 29, 2021Applicant: CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Zhong CAO, Jia YANG, Chen LIU, Zhongliang XIAO, Dan LI, Ling ZHANG, Yuyang ZHANG, Jiaxin LI
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Publication number: 20210025846Abstract: A method and a sensor for detecting L-cysteine based on a 3,3?-dithiobis (1-propanesulfonate)-mercury composite membrane are provided.Type: ApplicationFiled: August 24, 2019Publication date: January 28, 2021Applicant: CHANGSHA UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Zhong CAO, Yuyu PENG, Chen LIU, Ling TANG, Qin ZHU, Min JIN, Jinglin HE, Zhongliang XIAO